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  • 1975-1979  (5)
  • 1970-1974  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Uptake of free and DNA-bound daunorubicin and doxorubicin into human leukemic cells (1979)
    Springer
    Cancer chemotherapy and pharmacology 2 (1979), S. 49-52 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Leukemic cells from seven patients with acute nonlymphoblastic leukemia and granulocytes, and mononuclear cells from three healthy controls were isolated by centrifugation on metrozoate-dextran. The intracellular accumulation of both the free and DNA-bound forms of daunorubicin and doxorubicin was studied in vitro. The uptake of unbound daunorubicin was higher than that of doxorubicin. At drug concentrations of 1.75 μM and higher the uptake of the free drugs was greater than that of the bound forms, but at lower drug concentrations the uptake was about the same. This could at least partly be explained by a greater dissociation of the DNA-drug complexes at lower drug concentrations. The uptake into normal leukocytes was of the same order of magnitude as that into leukemic cells. There was a great interindividual variation in the accumulation of both free and DNA-bound drugs in the cells from leukemic patients. This variation might be of importance for the prediction of individual sensitivity to the different drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253105
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Treatment of acute nonlymphoblastic leukemia in adults with daunorubicin-DNA complex: A preliminary report (1979)
    Springer
    Cancer chemotherapy and pharmacology 2 (1979), S. 73-76 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Forty-four adult patients under 60 years of age with acute nonlymphoblastic leukemia were randomized for induction treatment with one of the following three regimens: R 1 = courses of daunorubicin on day 1+ARA-C on days 1–5; R 2 = courses of daunorubicin on days 1 and 2+ARA-C on days 4–8; R 3 = courses of daunorubicin-DNA complex on days 1–2+ ARA-C on days 4–8. Out of 14 patients, 9 went into remission on R 1, 6 out of 14 on R 2, and 8 out of 16 on R 3. The preliminary results suggest that daunorubicin-DNA complex has the same efficacy for inducing remission as daunorubicin alone, if the same time intervals and dosages are used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253109
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Velocity anomalies: An alternative explanation based on data from laboratory experiments (1978)
    Springer
    Pure and applied geophysics 116 (1978), S. 765-772 
    Details
    ISSN: 1420-9136
    Keywords: Velocity anomalies ; Microfractures ; Stick-slip
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Locations and velocities were calculated for microseisms occurring in samples of rock subjected to triaxial loading and injection of pore fluid. This was accomplished by analyzing arrival times of acoustic emission using an automatic first arrival picker. Apparent velocity anomalies were observed prior to both failure of intact samples and violent slip in samples containing saw cuts. Further analysis revealed that these fluctuations in calculated velocity were not due to changes in the true seismie velocity. Instead, variations in calculated velocity are shown to be related to sampling errors in picking first arrivals. The systematic picking of late first arrivals for small magnitude events was found to be a persistent bias resulting in low calculated velocities. This has encouraged the reexamination of earthquake records to determine how important sampling biases are in contributing to reported velocity anomalies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00876537
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Shear and tension hydraulic fractures in low permeability rocks (1977)
    Springer
    Pure and applied geophysics 115 (1977), S. 191-198 
    Details
    ISSN: 1420-9136
    Keywords: Stress hydrofracture ; Hydrofracture technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Laboratory hydrofracture experiments were performed on triaxially stressed specimens of oil shale and low-permeability granite. The results show that either shear or tension fractures could develop depending on the level of differentials stress, even in specimens containing preexisting fractures. With 1 kb of confining pressure and differential stress greater than 2kb, hydraulic fluid diffusion into the specimens reduced the effective confining pressure until failure occurred by shear fracture. Below 2kb of differential stress, tension fractures occurred. These results suggest that hydraulic fracturing in regions of significant tectonic stress may produce shear rather than tension fractures. In this casein situ stress determinations based on presumed tension fractures would lead to erroneous results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01637103
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Adjuvant immunotherapy in acute nonlymphocytic leukemia (1978)
    Springer
    Cancer immunology immunotherapy 4 (1978), S. 179-183 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Of 112 patients (maximum age 70 years) with acute nonlymphocytic leukemia, 62 (55%) went into remission on an induction therapy of cytosine arabinoside and daunorubicin. 20 patients were randomized for maintenance treatment consisting of chemotherapy only and 22 patients for combined chemo-immunotherapy. The chemotherapy consisted in 5-day courses of daunorubicin and cytosine arabinoside and of thioguanine and cytosine arabinoside, alternating every month. The chemo-immunotherapy group also received weekly intracutaneous injections of 109 allogeneic nonirradiated leukemic myeloblasts and 106 BCG organisms (Glaxo) by Heaf gun. The median duration of the first remission was 164 days for the chemotherapy group and 464 days for the chemo-immunotherapy group. The corresponding median times of survival were 344 days for the first group and 734 days for the second group. The difference concerning median duration of survival is statistically significant. Thus immunotherapy seems to prolong survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00204737
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Die Einwirkung des Krebses auf den Zellumsatz verschiedener Organe der Maus (1972)
    Springer
    Journal of cancer research and clinical oncology 77 (1972), S. 1-8 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde der DNS-Umsatz in den Organen von mit solid-wachsendem ELD-Krebs inokulierten Mäusen mittels 14C-Thymidin studiert. Bei einer Tumorgröße von 13% des Körpergewichtes ist das Gesamtkörpergewicht unverändert somit eine relative Kachexie anzeigend. Das Darmfett nahm ab. Leber und Milz zeigten Gewichtszunahme und deutliche Zeichen gesteigerter DNS-Synthese. Die übrigen Organe zeigten keine signifikanten Veränderungen im Zellumsatz. In Nieren und Muskeln ließ sich eine kurzfristige Stimulation der DNS-Synthese kleinerer Zellpopulationen als unmittelbare Folge der Krebsinoculation wahrscheinlich machen. Frühzeitiger Aktivitätsabfall in der Milz im Verein mit gleichzeitigem Anstieg in Leber, Nieren und Muskeln kann auf Zellwanderung hindeuten.
    Notes: Summary The turnover of DNA was studied by means of thymidiny14C in different organs of mice inoculated with solid growing ELD tumor. At a tumor size of 13% of body weight, total body weight is unchanged indicating relative kachexiay The mesenteric fat decreased. The liver and spleen increased in weight, a change that was accompanied by increased DNA synthesis. The DNA-turnover of all other organs remained unchanged. In the kidneys and muscles smaller cell populations were stimulated by the tumor inoculation to a transitory increase of DNA-synthesis. An early decrease of label in the spleen and a concomitant increase in the liver, kidney and muscle may indicate cell migration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284348
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    Paper (German National Licenses)
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