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  • 1975-1979  (2)
  • 5-Hydroxytryptamine  (1)
  • Depression  (1)
  • 1
    Digitale Medien
    Digitale Medien
    The effects of protriptyline and clomipramine in vitro on the uptake of 5-hydroxytryptamine and dopamine in human platelet-rich plasma (1975)
    Springer
    Psychopharmacology 43 (1975), S. 89-93 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Uptake ; Platelets ; 5-Hydroxytryptamine ; Dopamine ; Inhibition ; Protriptyline ; Clomipramine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effects of protriptyline and clomipramine, at concentrations of 10−7 M to 10−4 M, were studied in vitro on the uptake of 5-hydroxytryptamine and dopamine uptake in human platelet-rich plasma. It was found that the tertiary amine, clomipramine, was a more potent inhibitor of 5-hydroxytryptamine uptake than the secondary amine, protriptyline. The activity of both compounds was competitive but it was thought unlikely that they acted through tryptamine receptor sites as methysergide 2.5×10−8 M had very little effect on 5-hydroxytryptamine uptake. Neither tricyclic antidepressant had any marked effect on dopamine uptake.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00437621
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Clinical pharmacological studies of tandamine, a potential antidepressive drug (1977)
    Springer
    Psychopharmacology 52 (1977), S. 73-77 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Tandamine ; Tyramine pressor response ; Anticholinergic ; Appetite ; Sedation ; Depression ; Platelet ; Plasma concentration ; Monoamines
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Tandamine hydrochloride, a thiopyranoindole, was more active than desmethylimipramine in inhibiting the tyramine pressor response after single oral doses in human volunteers. When compared with a placebo, tandamine was found to possess significant anticholinergic activity, to reduce appetite and to produce sedation. Compared with clomipramine, it caused a smaller inhibition of 5-HT but a more marked inhibition of dopamine uptake into human platelets. Further clinical and pharmacological studies with tandamine may help to elucidate the respective roles of different monoamines in depression, sedation and appetite.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00426603
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
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