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Digitale Medien

Clinical pharmacological studies of tandamine, a potential antidepressive drug (1977)

Ehsanullah, Raihana S. B. ; Ghose, Karabi ; Kirby, Marilyn J. ; [weitere]

Springer

Psychopharmacology 52 (1977), S. 73-77

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Details

ISSN: 1432-2072

Schlagwort(e): Tandamine ; Tyramine pressor response ; Anticholinergic ; Appetite ; Sedation ; Depression ; Platelet ; Plasma concentration ; Monoamines

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Tandamine hydrochloride, a thiopyranoindole, was more active than desmethylimipramine in inhibiting the tyramine pressor response after single oral doses in human volunteers. When compared with a placebo, tandamine was found to possess significant anticholinergic activity, to reduce appetite and to produce sedation. Compared with clomipramine, it caused a smaller inhibition of 5-HT but a more marked inhibition of dopamine uptake into human platelets. Further clinical and pharmacological studies with tandamine may help to elucidate the respective roles of different monoamines in depression, sedation and appetite.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00426603

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