ISSN:
1432-2072
Keywords:
Aggression
;
Morphine Addiction
;
Apomorphine
;
Dopamine Receptors
;
Receptor Supersensitivity
;
Narcotic Abstinence
;
Nigrostriatal Lesion
;
Medial Forebrain Bundle Lesion
;
Protracted Abstinence
;
Dopamine Turnover
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Reliable aggression was seen in rats which were grouped 30 days after undergoing continuous withdrawal from morphine. This withdrawal aggression, associated with long-lasting effects of morphine dependence, was blocked by morphine or lesions of the nigrostriatal bundle, but not by lesions of the median forebrain bundle. When the nigrostriatal lesioned rats were treated with a small dose of apomorphine, the aggression was reinstated. Apomorphine reduced the turnover of dopamine in the 30-day withdrawn rats at doses which were ineffective in similarly housed non-dependent rats. These results suggest that animals undergoing protracted morphine abstinence show aggression due to a latent dopaminergic supersensitivity, similar to that previously reported during acute narcotic withdrawal.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00421218
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