ISSN:
1432-0428
Keywords:
Chinese hamster
;
diabetes
;
ketonuria
;
survival rates
;
epidemiology
;
urinary incontinence
;
genetic heterogeneity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Two populations of Chinese hamsters have been produced. The nondiabetic population was from nondiabetic parents and the diabetic-producing population was from diabetic parents. Both populations had fixed reproducible genetic background since dams and sires were from inbred sublines. Sixty percent of males, but only 37% of females, born to diabetic parents developed diabetes.— Life span for males was nondiabetics 〉 mild diabetics 〉 ketonuric diabetics. Results for females were equivocal. Mortality of severe ketonuric diabetics appears to be related to urinary tract involvement. Survival appears to be related to abnormal metabolism, not genotype. On the basis of available data males appear more suitable for epidemiological studies on the incidence, onset, and severity of diabetes, on the evaluation of treatment of the disease, and on the longevity of diabetics. —Data on crossing diabetics from different sublines suggest that diabetic Chinese hamsters can have different genotypes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01221989
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