ISSN:
1432-0428
Keywords:
Insulin secretion
;
glucagon secretion
;
Chinese hamster
;
glucose
;
arginine
;
theophylline
;
subline variation
;
chemical diabetic
;
latent diabetic
;
high-fat diet
;
effect of diet
;
glucose tolerance test
;
pancreatic insulin content
;
pancreatic glucagon content
;
perfused hamster pancreas
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Insulin and glucagon release (in response to glucose, theophylline, and arginine) were measured from thein vitro perfused pancreases of non-ketotic diabetic Chinese hamsters. These animals showed impaired alpha and beta cell sensitivity to glucose (i.e. excessive glucagon, and a reduction in both phases of insulin release) and abnormal alpha cell sensitivity to arginine (excessive glucagon), but normal responses to theophylline. Pancreatic insulin content was significantly decreased and glucagon content increased in unperfused diabetic pancreases. Abnormal responses to glucose and arginine were not directly related to pancreatic content, since responses to theophylline were normal. Insulin responses of normal animals from five normal sublines and non-ketotics from eight diabetic sublines were compared; certain diabetic sublines showed significantly less insulin release than did others, despite similar severities of glucosuria. — Fasting blood glucose during stress, glucose tolerance, andin vitro pancreatic insulin responses to glucose were measured in the normoglycemic, aglucosuric siblings of diabetics; the responses were diabetic-like, and therefore such animals are referred to here as “chemical diabetics”. — The incidence of glucosuria and ketonuria was studied in ketotic diabetic hamsters on high- and low-fat diets; glucosuria decreased and ketonuria disappeared on the low-fat diet.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01221982
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