ISSN:
1432-069X
Keywords:
Key words Type VII collagen
;
Pruriginosa
;
Anchoring fibril
;
Basement membrane
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Dystrophic epidermolysis bullosa (DEB), caused by mutations in the gene encoding type VII collagen (COL7A1), is known to show heterogeneous clinical phenotypes. Certain correlations between the nature or position of COL7A1 mutations and the resultant DEB phenotypes have been suggested, although such relationships may be more complex than initially thought. The purpose of the present study was to clarify the molecular basis of two different subtypes of dominant DEB (DDEB), EB pruriginosa and classical type. Interestingly, we found that both cases were caused by a missense glycine substitution mutation by different amino acids in the same codon of COL7A1 (G2028R and G2028A). These results further support the notion that different glycine substitution mutations in the same codon can lead to heterogeneous clinical phenotypes of DDEB, EB pruriginosa and classical type.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004030000162
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