ISSN:
1420-908X
Keywords:
Asthma
;
β-agonist
;
Mast cells
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The mast cell protective effects of the newly developed long-actingβ 2-adrenergic salmeterol and formoterol were compared with those of conventionally usedβ 2-adrenergic, non-specific β-agonists, disodium cromoglycate (DSCG) and theophylline. With the exception of DSCG, all the test agents inhibited ovalbumin-induced histamine release from enzymically dispersed guinea pig lung mast cells in a dose-dependent fashion. At the maximum concentration tested, theophylline produced the highest level of protection, inhibiting up to 90% of ovalbumin-induced histamine release whereas DSCG produced only 10% inhibition. The maximum inhibition produced by all theβ 2-adrenergic tested was around 45%. While salmeterol was equipotent with salbutamol, formoterol was at least a 100-fold more potent. Hence the present study confirmed the previously reported mast cell stabilizing actions of conventionalβ 2-adrenergic and extended the observation to the newly developed long-acting analogues.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01983471
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