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  • 1
    ISSN: 0014-5793
    Keywords: Autolysis ; Calcium ; Proteolysis ; m-Calpain
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0014-5793
    Keywords: Autolysis ; Calcium ; Proteolysis ; m-Calpain
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 351 (1995), S. 610-617 
    ISSN: 1432-1912
    Keywords: Key words Ferret ; Ventricular myocytes ; Acetylcholine ; Adenosine ; Muscarinic K+ channel ; G protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The properties of the K+ channel activated by acetylcholine (ACh) and adenosine (Ado) were examined in single ferret ventricular myocytes using patch-clamp techniques. In the whole-cell configuration, ACh and Ado induced an inwardly rectifying K+ current and shortened the action potential duration. The effect of ACh was blocked by atropine, while the Ado effect was interrupted by 8-cyclopentyl,1,2-dipropyl xanthine, a specific Ado A1 receptor antagonist. In cell-attached recordings, ACh and Ado added to the pipette solution activated a single population of inwardly rectifying K+ channels, distinct from the i K1 channel. The channel had a slope conductance of ∼40 pS in symmetrical 150 mM K+ solutions and a mean open time of 0.8 ms. Excision of the patch into the inside-out patch configuration in guanosine triphosphate (GTP)-free solution abolished the channel activity. The channel was reversibly reactivated by adding GTP to the intracellular side of the patch. GTPγS activated the channel irreversibly. When the inside-out patch was treated with the A protomer of pertussis toxin (PTX), intracellular GTP no longer activated the K+ channel. The results show that ferret ventricular myocytes possess a K+ channel activated by both muscarinic and Ado A1 receptors. Its electrophysiological properties and the gating by a PTX-sensitive G protein in a membrane-delimited fashion are identical with those of the muscarinic K+ channels in nodal and atrial tissues of other species. In conclusion, the G protein-gated muscarinic K+ channel is expressed in ferret ventricular myocardium and may underlie the direct negative inotropism of ACh and Ado in this tissue.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0649
    Keywords: 42.80 ; 07.65 ; 82.80
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract This paper reports and discusses, for the first time, the all-optical remote monitoring method for spilled dispersals or leakages in air of city gas through the nearinfrared absorption of CH4 gaseous molecules as one of its major constituents, using a very low-loss optical fiber network and compact absorption cells in conjunction with high radiant InGaAsP light-emitting diodes (LEDs). For this new application, the near-infrared absorption spectra of city gas (Sendai, Japan) were measured and analyzed to find a relatively strong absorption due to thev 2 + 2v 3 combination band of CH4 molecules around the wavelength region of 1.33 μm. By using a 2-km long very low-loss silica optical fiber link, this fully optical system was demonstrated to be feasible, safe and capble of achieving reproducibly the detection sensitivity of nearly 1 Torr of CH4 gas in air, i.e., 2.6% of the lower explosion limit of CH4 density in air. This result supports the conclusion that the alloptical remote sensing system incorporating very low-loss optical fiber networks and LEDs or laser diodes (LDs) in the near-infrared region can be extensively utilized for the real-time detection and surveillance of spills or leakages of the city gas or any other gas mixtures as well as various combustible, explosive, dangerous, and toxic gases not onlyin industrial and mining complexes but also in urban and residential areas.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 38 (1985), S. 11-15 
    ISSN: 1432-0649
    Keywords: 42.68 ; 42.80 ; 07.65
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract This paper reports for the first time the fully optical remote monitoring of low-level CH4 gas with a wide area coverage of 10 km in diameter realized by utilizing ultralowloss silica optical fibre link and a compact absorption cell in conjunction with highly radiant InGaAsP and InGaAs light emitting diodes (LEDs) in the near infrared region. For this novel application, the near-infrared absorption spectra of CH4 molecules were measured and studied involving the ν2+2ν3 combination band around 1.33 μm and the 2ν3 overtone band around 1.66 μm. This fibre-optic system was demonstrated to be feasible and sufficiently sensitive and safe as being a practical CH4 gas remote sensor whose detection sensitivity is normally required to be 25% of the lower explosion limit (LEL) of CH4 gas in air. This result verifies a large potential for applying extensively to various strategic points within the environment, such as industrial and mining complexes as well as urban and residential areas, with considerably increased reability, safety and marketability over the presently available techniques.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 351 (1995), S. 610-617 
    ISSN: 1432-1912
    Keywords: Ferret ; Ventricular myocytes ; Acetylcholine ; Adenosine ; Muscarinic K+ ; channel ; G protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The properties of the K+ channel activated by acetylcholine (ACh) and adenosine (Ado) were examined in single ferret ventricular myocytes using patch-clamp techniques. In the whole-cell configuration, ACh and Ado induced an inwardly rectifying K+ current and shortened the action potential duration. The effect of ACh was blocked by atropine, while the Ado effect was interrupted by 8-cyclopenty1,1,2-dipropyl xanthine, a specific Ado A1 receptor antagonist. In cell-attached recordings, ACh and Ado added to the pipette solution activated a single population of inwardly rectifying K+ channels, distinct from the i K1 channel. The channel had a slope conductance of ∼ 40 pS in symmetrical 150 mM K+ solutions and a mean open time of 0.8 ms. Excision of the patch into the inside-out patch configuration in guanosine triphosphate (GTP)-free solution abolished the channel activity. The channel was reversibly reactivated by adding GTP to the intracellular side of the patch. GTPγS activated the channel irreversibly. When the inside-out patch was treated with the A protomer of pertussis toxin (PTX), intracellular GTP no longer activated the K+ channel. The results show that ferret ventricular myocytes possess a K+ channel activated by both muscarinic and Ado A1 receptors. Its electrophysiological properties and the gating by a PTX-sensitive G protein in a membrane-delimited fashion are identical with those of the muscarinic K+ channels in nodal and atrial tissues of other species. In conclusion, the G protein-gated muscarinic K+ channel is expressed in ferret ventricular myocardium and may underlie the direct negative inotropism of ACh and Ado in this tissue.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
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