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  • 1
    Electronic Resource
    Electronic Resource
    Excessive myocardial calcinosis in a chronic hemodialyzed patient (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 97-100 
    Details
    ISSN: 1432-1440
    Keywords: Myocardial calcinosis ; Hemodialysis ; Hyperoxalemia ; Ascorbic acid ; Calcium oxalate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Secondary oxalosis in chronic hemodialyzed patients is caused by impaired renal excretion and inadequate removal of oxalic acid during hemodialysis. Ascorbic acid is a precursor of oxalic acid. We report a parathyroidectomized patient with chronic renal failure, on hemodialysis, who received over a period of several months a total dose of 91.0 g ascorbic acid i.v. The plasma oxalic acid level in this patient was 14-fold higher than in healthy persons. Increased oxalic acid synthesis from its precursor ascorbic acid may be responsible for hyperoxalemia, high content of oxalic acid in myocardium, aorta and lung, and calcium oxalate deposition in soft tissues. Application of high doses of ascorbic acid should be avoided in hemodialysed patients with chronic renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745485
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Sensitivity of125J-fibrinogen uptake test for diagnosis of established venous thrombosis in heparinized patients (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 227-230 
    Details
    ISSN: 1432-1440
    Keywords: 125J-fibrinogen uptake test ; Venous thrombosis ; Anticoagulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The sensitivity of the radiofibrinogen test was investigated to determine the accuracy of the test in diagnosis of venographically proven venous thrombosis in 70 heparinized patients.125J-fibrinogen was administered between 2 h and 4 days (mean: 1.5 days) after initiating heparin therapy. There were two criteria for a positive test: (a) if the difference between the counts for adjacent points on the same leg or equivalent sites on opposite legs was at least 15%; and/or (b) if there were three adjacent points each with counts 〉5% that of the same three points on the other leg. The fibrinogen uptake test was positive at the first examination in 67 of 70 patients, giving a sensitivity of 96%. The respective frequencies of truly abnormal results for the 3×5% and the 1×15% criteria were 94% and 71%. As far as localization and extension of thrombosis were concerned, the fibrinogen uptake test agreed with phlebography in 73% of the cases, when the counts in the groin and the upper third of the thigh were ignored. The125J-fibrinogen uptake test is an accurate method for detecting established deep leg vein thrombosis even in anticoagulated patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711653
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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