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  • 1
    ISSN: 1432-1440
    Keywords: β-Thromboglobulin ; Platelet factor 4 ; Peripheral arterial occlusive disease ; Exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated the behavior of β-thromboglobulin (β-TG) and platelet factor 4 (PF 4) during exercise — upright bicycle ergometry — in 30 patients (median age, 62.4 years) with arteriographically proven peripheral arterial occlusive disease (PAOD) in a chronic stable phase. In 15 patients the exercise study was done twice; the second time was concurrent with administration of acetylsalicylic acid (ASA) in a dosage of 1.0 g/day, while the first time was without ASA therapy. There were no significant differences in either the group of patients with or that without ASA with regard to the platelet-specific proteins at rest, immediately after, and 30 min after exercise. Blood collected simultaneously (n=6) from an arm vein and from a femoral artery and femoral vein also revealed no significant differences. Our findings support the conclusion that exercise-induced peripheral ischemia with severe symptoms of claudication does not produce platelet alpha-granule release.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 62 (1984), S. 531-532 
    ISSN: 1432-1440
    Keywords: Nephrotic syndrome ; Fibronectin ; Fibrinogen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In nine patients with nephrotic syndrome the behaviour of plasma fibronectin was studied. Of nine patients seven showed elevated plasma fibronectin levels while the plasma fibrinogen level was increased in eight of the nine investigated patients. A positive correlation was found between plasma fibronectin levels and fibrinogen (P〈0.01), cholesterol (P〈0.01) and proteinuria (P〈0.05). The results indicate that elevated plasma fibronectin levels could be an additional factor responsible for hypercoagulability in nephrotic syndrome.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 63 (1985), S. 190-191 
    ISSN: 1432-1440
    Keywords: Hirudin ; Arteriovenous fistula ; Haemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this pilot study we tested the effect of an ointment containing hirudin in a high concentration [20,000 ATU (antithrombin units)/100 g ointment] in ten patients on maintenance haemodialysis (six men, four women; mean age: 51 years; mean duration of dialysis treatment: 20.4 months). The duration of hirudin application was 4.5 months, the observation period in the total group was 43 months. During the total dialysis period of 204 months — before hirudin application — in these ten patients a shunt thrombectomy was necessary 18 times because of shunt occlusion. A shunt-thrombosis occurred in none of the ten patients during the period of application of the hirudincontaining ointment.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1440
    Keywords: 125J-fibrinogen uptake test ; Venous thrombosis ; Anticoagulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The sensitivity of the radiofibrinogen test was investigated to determine the accuracy of the test in diagnosis of venographically proven venous thrombosis in 70 heparinized patients.125J-fibrinogen was administered between 2 h and 4 days (mean: 1.5 days) after initiating heparin therapy. There were two criteria for a positive test: (a) if the difference between the counts for adjacent points on the same leg or equivalent sites on opposite legs was at least 15%; and/or (b) if there were three adjacent points each with counts 〉5% that of the same three points on the other leg. The fibrinogen uptake test was positive at the first examination in 67 of 70 patients, giving a sensitivity of 96%. The respective frequencies of truly abnormal results for the 3×5% and the 1×15% criteria were 94% and 71%. As far as localization and extension of thrombosis were concerned, the fibrinogen uptake test agreed with phlebography in 73% of the cases, when the counts in the groin and the upper third of the thigh were ignored. The125J-fibrinogen uptake test is an accurate method for detecting established deep leg vein thrombosis even in anticoagulated patients.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 65 (1987), S. 97-100 
    ISSN: 1432-1440
    Keywords: Myocardial calcinosis ; Hemodialysis ; Hyperoxalemia ; Ascorbic acid ; Calcium oxalate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Secondary oxalosis in chronic hemodialyzed patients is caused by impaired renal excretion and inadequate removal of oxalic acid during hemodialysis. Ascorbic acid is a precursor of oxalic acid. We report a parathyroidectomized patient with chronic renal failure, on hemodialysis, who received over a period of several months a total dose of 91.0 g ascorbic acid i.v. The plasma oxalic acid level in this patient was 14-fold higher than in healthy persons. Increased oxalic acid synthesis from its precursor ascorbic acid may be responsible for hyperoxalemia, high content of oxalic acid in myocardium, aorta and lung, and calcium oxalate deposition in soft tissues. Application of high doses of ascorbic acid should be avoided in hemodialysed patients with chronic renal failure.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1440
    Keywords: Echocardiography ; Cross sectional echocardiography ; Endocarditis ; Echokardiographie ; Schnittbildechokardiographie ; Endocarditis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Um die Möglichkeiten und Grenzen der Schnittbildechokardiographie bei der Diagnose der bakteriellen Endocarditis zu untersuchen wurden M-mode und Schnittbildechokardiogramme von 39 Patienten mit gesicherter Endocarditis und/oder endocarditisverdächtigem Schnittbildechokardiogramm analysiert. Das Echokardiogramm galt als Endocarditis-verdächtig wenn Zeichen für valvuläre oder murale Vegetationen und/oder Hinweise für eine Klappendestruktion nachgewiesen werden konnten. Achtundzwanzig Patienten hatten eine Endocarditis, welche in acht Fällen bereits ausgeheilt war. Im Schnittbildechokardiogramm (SBE) konnte die Diagnose bei 18 Patienten (64%) gestellt werden. Bei zwei weiteren wurden sehr große Vegetationen zwar gesehen aber irrtümlich als Vorhofmyxom bzw. linksatrialer Thrombus interpretiert. Bei den übrigen acht Patienten konnten die durch die Endocarditis bedingten Veränderungen im SBE nicht nachgewiesen werden. Mittels SBE wurden neun endocarditisch veränderte Mitralklappen, 12 Aortenklappen, eine Tricuspidalklappe und fünf murale Vegetationen entdeckt, mindestens 15 weitere nachgewiesenermaßen vorhandene endocarditische Veränderungen wurden jedoch übersehen. Bei 30 Patienten mit Endocarditis-verdächtigen Veränderungen im SBE waren konklusive klinische Daten verfügbar. Bei 11 von ihnen (37%) konnten wir bei einer Analyse von Anamnese, klinischen und laborchemischen Daten keinen Anhaltspunkt für eine frische oder ausgeheilte Endocarditis finden. Bei einem Fall mit Endocarditis wurde die Diagnose an der falschen Klappe gestellt. Im SBE konnten im Vergleich zur M-mode Technik Vegetationen, insbesondere kleine oder mural gelegene, häufiger erkannt werden. Auch das Durchschlagen von Klappensegeln durch die Klappenebene war im Schnittbildverfahren besser zu erkennen. Zum Nachweis von Flatterbewegungen perforierter Klappen war hingegen der M-mode besser geeignet. Trotz dieser scheinbar enttäuschenden Ergebnisse ist die Echokardiographie bei der Diagnose der Endocarditis sehr hilfreich, wenn gleichzeitig auch die klinischen Befunde berücksichtigt werden. Oft liefert das Echokardiogramm bei fiebernden Patienten den ersten Hinweis oder bestätigt den klinischen Verdacht. Obwohl eine Vielzahl von Klappenabnormalitäten z.B. myxoide Degeneration und Mitralklappenprolaps, Lupus Endocarditis, abgeheilte rheumatische Valvulitis ohne Stenose, Thromben in Klappennähe, spontane Sehnenfadenruptur usw. das echokardiographische Bild einer Endocarditis imitieren können, ist es bei Kenntnis der klinischen und laborchemischen Befunde in der Regel möglich, falsch positive Befunde als solche zu erkennen. Die Diagnose oder der Ausschluß einer Endocarditis allein auf Grund des Echokardiogramms ist allerdings nicht zulässig.
    Notes: Summary We have analyzed the cross sectional and M-mode echocardiograms of 39 patients, who fulfilled one or both of the following criteria: 1) well documented infective endocarditis=IE (active or healed); 2) Cross sectional echocardiographic evidence of IE: findings compatible with valvular or mural1 vegetations and/or signs of valve destruction and leaflet rupture. Patients in whom IE could neither be definitely diagnosed nor excluded were eliminated from the study. There were 28 patients with IE, eight of them had healed IE. In 18 of these 28 patients (64%) IE could be diagnosed by cross sectional echocardiography (CSE). In two other patients huge vegetations were seen but erroreously interpreted as “left atrial myxoma” and “left atrial mural thrombus” respectively. In the remaining eight patients CSE did not reveal the endocarditic lesion. Cross sectional echocardiography idendified nine affected mitral valves, 12 aortic valves, one tricuspid valve and five mural vegetations but missed 15 additional lesions. There were 30 patients with CSE findings compatible with IE in whom conclusive clinical data were available. In 11 (37%) of them we found no evidence of either active or healed IE as judged by history, physical and laboratory findings. In one additional patient (3, 6%) with IE the lesion had been diagnosed on a valve which was in fact not affected. When compared with the M-mode echocardiogram (MME) CSE was more successful in detecting vegetations (n=22 by CSE, versus 16 by MME), particularly if they were small or murally located. The flail motion pattern of torn leaflets was sometimes better appreciated by CSE but MME was better suited to detect the fine fluttering of perforated valves. False positive findings by CSE were confirmed by MME in nearly all cases. Despite these seemigly discouraging results echocardiography is very helpful when used in conjunction with the clinical findings. In febrile patients echocardiography frequently provides the first clue to the diagnosis or confirms the clinical suspicion. Although a variety of valvular abnormalities (myxoid degeneration and mitral valve prolapse, lupus-endocarditis, healed rheumatic valvulitis without stenosis, juxtavalvular thrombi, spontaneous mitral chordal rupture ect.) may mimic endocarditis echocardiographically, false positive diagnoses can usually be avoided when the clinical and laboratory findings are known. However infective endocarditis shoud never be diagnosed or excluded solely an the basis of a positive or negative echocardiograms.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1440
    Keywords: Cimetidine ; Pirenzepine ; Parathyroid hormone ; Calcitonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this study we evaluated the effects of an oral combination therapy with cimetidine and pirenzepine on plasma parathyroidhormone (PTH) and calcitonin (CT) levels in 24 patients on maintenance hemodialysis (mean age: 50 years; mean duration of dialysis treatment: 23 months). As compared to the pre-treatment plasma levels of PTH and CT, there were no significant changes of their plasma concentrations during a 4-week administration of 800 mg cimetidine or 100 mg pirenzepine daily, and the concentrations also did not change significantly during the following 4 weeks of combination therapy with cimetidine and pirenzepine in the above mentioned dosage. Serum concentrations of calcium and phosphate and the activity of the alkaline phosphatase showed no significant changes either. Therefore, we suggest that this therapeutic approach cannot be considered for the treatment of uremic hyperparathyroidism.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1041
    Keywords: cimetidine ; chronic haemodialysis ; pirenzepine ; uraemia ; parathormone ; plasma calcitonin ; secondary hyperparathyroidism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The acute effects of intravenous injection of cimetidine and pirenzepine on plasma iPTH and CT were studied in seven patients on chronic haemodialysis and seven healthy controls. As expected, the resting iPTH and CT levels were significantly higher in patients on RDT than in the healthy subjects. Both drugs decreased to a similar extent the increased plasma iPTH in the patients, but neither was able entirely to normalize the elevated level. The CT concentration in the patients on haemodialysis was significantly decreased by cimetidine but was only moderately reduced by pirenzepine. As neither drug was able to normalize the elevated PTH level in patients on chronic dialysis, it can be assumed that neither used alone would improve signs and symptoms of secondary hyperparathyroidism.
    Type of Medium: Electronic Resource
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  • 9
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    Assen : Periodicals Archive Online (PAO)
    Phronesis. 8 (1963) 127 
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  • 10
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    Unknown
    Pittsburgh, Pa., etc. : Periodicals Archive Online (PAO)
    Classical World. 46 (1952:Nov.-1953:May) 104 
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