ISSN:
1420-9071
Keywords:
D-Cysteinolic acid
;
platelet aggregation
;
inhibitor
;
marine product
;
2-aminoethyl disulfide
;
sardine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary D-Cysteinolic acid (1) analogues with an S-C-C-N skeleton showed increased platelet anti-aggregant activity in the following order: 2-aminoethanesulfonic acids, thiazolidines, 2-aminoethanethiols and 2-aminoethyl disulfides. Methyl substitutions at the 2-position potentiated the activity. Of these analogues, bis [(R)-2-aminopropyl] disulfide was the most potent inhibitor of platelet aggregation, with about 600-fold the activity of (1).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01950172
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