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  • Polymer and Materials Science  (8)
  • Life and Medical Sciences  (5)
  • Islet of Langerhans  (3)
  • 21.10.Re  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Nitric oxide is not involved in the initiation of insulin secretion from rat islets of Langerhans (1992)
    Springer
    Diabetologia 35 (1992), S. 1020-1027 
    Details
    ISSN: 1432-0428
    Keywords: Islet of Langerhans ; insulin secretion ; nitric oxide ; cyclic guanosine monophosphate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The involvement of nitric oxide as an intracellular messenger in the control of insulin secretion from pancreatic Beta cells was studied in rat islets of Langerhans by measuring: (i) nitric oxide generation in response to physiological insulin secretagogues; (ii) the effects of inhibitors of nitric oxide synthesis on insulin secretory responses to physiological secretagogues, and on insulin synthesis; (iii) changes in islet cyclic guanosine monophosphate in response to secretagogues; (iv) the effects of exogenous cyclic guanosine monophosphate and dibutyryl cyclic guanosine monophosphate on insulin secretion from electrically permeabilised islets and from intact islets, respectively. These studies produced no evidence that nitric oxide generation is required for the initiation of insulin secretion by common secretagogues. However, the results of our experiments suggest that the generation of nitric oxide may be involved in long-term, glucose-dependent increases in cyclic guanosine monophosphate content of islet cells, although the physiological relevance of these changes requires further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02221676
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  • 2
    Electronic Resource
    Electronic Resource
    The role of protein kinase C in insulin biosynthesis (1993)
    Springer
    Acta diabetologica 30 (1993), S. 99-104 
    Details
    ISSN: 1432-5233
    Keywords: Insulin synthesis ; Islet of Langerhans ; Northern blotting ; Phorbol ester ; Protein kinase C
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Activation of protein kinase C (PKC) by the phorbol ester 4β-phorbol myristate acetate (4β-PMA) stimulated (pro)insulin biosynthesis in collagenase-isolated rat islets of Langerhans, as assessed by measuring the incorporation of [35S]cysteine into proinsulin and insulin after fractionation by high performance liquid chromatography. The stimulatory effects of 4β-PMA were observed at a substimulatory concentration of glucose (2 mM) but were not additive to the stimulatory effects of 20 mM glucose on insulin biosynthesis. Prolonged exposure to 4β-PMA caused a marked down-regulation of PKC activity in islets. PKC-depleted islets showed a much reduced biosynthetic response to 20 mM glucose, but this was caused, at least in part, by an enhanced basal rate of (pro)insulin synthesis. These elevations in the basal rate of insulin synthesis were not secondary to an inerease in the amount of preproinsulin mRNA in PKC-depleted islets since Northern blot analysis showed that prolonged exposure to 4β-PMA, and the subsequent loss of PKC activity, did not detectably alter basal levels of preproinsulin mRNA. These results suggest that the activation of PKC stimulates (pro)insulin synthesis in rat islets by enhancing translation of existing preproinsulin mRNA, and that this may play some part in the biosynthetic responses of β-cells to glucose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00578222
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  • 3
    Electronic Resource
    Electronic Resource
    Protein phosphorylation in the regulation of insulin secretion: the use of site-directed inhibitory peptides in electrically permeabilised islets of Langerhans (1995)
    Springer
    Acta diabetologica 32 (1995), S. 32-37 
    Details
    ISSN: 1432-5233
    Keywords: Islet of Langerhans ; Insulin secretion ; Protein phosphorylation ; Protein kinase C ; Protein kinase A ; Inhibitory peptides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have used electrically permeabilised rat islets of Langerhans to investigate the role of protein phosphorylation in the regulation of insulin secretion using pseudosubstrate inhibitory peptides for cyclic AMP-dependent protein kinase (PKA) and for protein kinase C (PKC). The protein kinase inhibitor (PKI) peptide, PKI(6–22), completely inhibited the effects of cyclic AMP on islet PKA activity in vitro, on endogenous protein phosphorylation and on insulin secretion. This peptide had no significant effect on islet PKC activity in vitro, on CA2+-induced protein phosphorylation and on secretory responses to Ca2+ or to the PKC activator, 4β-phorbol myristate acetate (PMA). The PKC pseudosubstrate inhibitory peptide, PKC(19–36), caused a marked inhibition of islet PKC activity in vitro and inhibite PMA-induced insulin secretion without affecting secretory responses to cyclic AMP and Ca2+. These results demonstrate that PKA-and PKC-induced protein phosphorylation is obligatory for cyclic AMP-and PMA-stimulated insulin secretion, respectively, and suggest that there is little “crosstalk” between the response elements of the secretory pathways to the different, second messengers, at least after the generation of the messengers within the β-cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581042
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  • 4
    Electronic Resource
    Electronic Resource
    Evidence of Multiple Shape-Coexistence in 188Pb (2000)
    Springer
    EPJ direct 1 (2000), S. 1-6 
    Details
    ISSN: 1435-3725
    Keywords: 23.20.Nx ; 29.30.Dn ; 23.20.Lv ; 21.10.Re ; 25.70.Jj ; 27.70.+q
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using conversion electron and γ-ray spectroscopy combined with a recoil gating method, excited states in 188Pb have been investigated. Further evidence for two excited low-lying 0+ states has been found leading to an interpretation as a multiple shape coexistence in 188Pb.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s1010599a0003
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  • 5
    Electronic Resource
    Electronic Resource
    Evidence of Multiple Shape-Coexistence in 188Pb (1999)
    Springer
    EPJ direct 1 (1999), S. 1-6 
    Details
    ISSN: 1435-3725
    Keywords: 23.20.Nx ; 29.30.Dn ; 23.20.Lv ; 21.10.Re ; 25.70.Jj ; 27.70.+q
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using conversion electron and γ-ray spectroscopy combined with a recoil gating method, excited states in 188Pb have been investigated. Further evidence for two excited low-lying 0+ states has been found leading to an interpretation as a multiple shape coexistence in 188Pb.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s1010599a0003
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  • 6
    Electronic Resource
    Electronic Resource
    Thermal degradation of polymers. Part III. Vacuum pyrolysis of poly(m-aminostyrene); the products volatile at pyrolysis temperature which are liquid or gaseous at room temperaturePaper presented at Thermal Analysis Group of Society of Analytical Chemistry Burlington House, London, on November 13th, 1968. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 13 (1969), S. 2033-2043 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The products obtained on degradation of poly(m-aminostyrene) in vacuo are described. The effect of molecular weight and pyrolysis temperature are discussed and the behavior of poly(m-aminostyrene) compared with that of polystyrene. Quantitative analytical methods using ultra-violet spectroscopy and gas liquid chromatography are described for m-aminostyrene and m-toluidine. The possible mechanisms of degradation to yield the products are discussed.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1969.070131001
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  • 7
    Electronic Resource
    Electronic Resource
    A positron annihilation lifetime study of isothermal structural relaxation in bisphenol-A polycarbonate (1988)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 26 (1988), S. 1541-1552 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Positron annihilation lifetime spectroscopy has been used to study the isothermal relaxation response of compression molded bisphenol-A polycarbonate at temperatures of 263, 273, and 303 K. The temperature dependence of both the lifetime and intensity of the ortho-Positronium (o-Ps) pickoff component is discussed in terms of ductile-to-brittle transition behavior and free volume theory. An additive exponential model and the Williams-Watt model were used to analyze the relaxation as a function of temperature and provided results consistent with the anticipated molecular mobility of polycarbonate at sub-Tg temperatures.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1988.080260605
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  • 8
    Electronic Resource
    Electronic Resource
    Structure of the deoxytetranucleotide d-pApTpApT and a sequence-dependent model for poly(dA-dT)Supplementary material on observed and calculated structure factors for d-pApTpApT is available from the authors. (1982)
    New York : Wiley-Blackwell
    Biopolymers 21 (1982), S. 513-533 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The x-ray structure of the hydrated ammonium salt of the deoxytetranucleotide d-pApTpApT was determined by Patterson and direct methods at a resolution of 1 Å. The crystal structure contains right-handed double-helical segments formed by complementary Watson-Crick-type hydrogen bonding between the adenine and thymine bases of neighboring molecules. The minihelix contains two base pairs. The chains are antiparallel. The A-T and T-A sequences have different phosphodiester conformations. The deoxyribose-pucker and the sugar-base orientation alternate along the chain depending on the nature of the base (3′-endo for purine and 2′-endo for pyrimidine). The extended structure is stabilized by base-base, base-sugar, and hydrogen-bond interactions. The minihelix of two base pairs provides starting coordinates for model-building studies of the dA-dT polymer. A B-DNA-type polymer structure is described, which has sequence-dependent alternations of both the deoxyribose pucker and the phosphate diester bridge conformation. Such sequence-dependent DNA structures, if present locally in regions such as operator sequences, could facilitate sequence-specific interactions. The crystal study also suggests possible geometrical parameters for the replication fork.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360210304
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  • 9
    Electronic Resource
    Electronic Resource
    A radiographic study of the longitudinal growth of primary ossification centers in limb long bones of the human fetus (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 203 (1982), S. 293-299 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: This paper describes an extensive study of the growth of ossification centers in limb long bones of the human fetus from 8 to 26 weeks of conceptual age. Longitudinal measurements were made of the femur, tibia, fibula, humerus, radius, and ulna. Comparisons were made between bones on the left and right sides of the body and between the sexes. Standards are presented for the growth of these centers. They compare well with previous studies, any differences being accounted for by different methods of aging and measurement.A complicated picture of growth of the two sides of the fetal body is presented. Growth of the humerus, tibia, and fibula appears to be dominant on the left side of the body while growth in the femur is dominant on the right. At present, no explanation is available, but it is possible that factors such as manual dominance may be related. Evidence also is presented which suggests that the female fetus is in advance of the male in terms of ossification but only after 21 weeks gestation.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092030211
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  • 10
    Electronic Resource
    Electronic Resource
    A radiographic study of the growth in width of the human fetal vertebral column (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 204 (1982), S. 265-270 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Only a few studies have concerned themselves with the development of the fetal vertebral column, and this paper attempts to extend the literature. Standards are presented for the growth in width of the human vertebral column between 10 and 26 weeks of conceptual age. The growth patterns show that cervical and lumbar enlargements are not present at 8 weeks but develop slowly and become clearly present at 26 weeks. The growth equations also show that groups of vertebrae have their own growth patterns, indicating that the vertebral column could be separated into five groups: C1-C5, C6-C7, T1-T12, L1-S1, and S2-S5. Furthermore, comparisons with growth patterns available for growth in length from other studies reveal that some vertebrae appear to develop in one dimension independently of another.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092040311
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