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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 5 (1972), S. 53-57 
    ISSN: 1432-1041
    Keywords: Rifampicin ; intermittent treatment ; immunological reaction with thrombocytopenia ; haemolytic anaemia ; renal failure and jaundice ; high-dose corticosteroid therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A case is reported in which a 36-year-old patient twice suffered a rapidly-developing severe reaction to intermittent rifampicin therapy. The symptoms were upper abdominal and back pain, nausea and shivering. Acute renal failure, thrombocytopenia, jaundice and haemolytic anaemia also developed. Aetiologically this was due to an immunopathological effect. This case was unusual in that all the previously observed reactions to rifampicin of an immunological aetiology occurred together, resulting in a marked leucocytosis with the presence of immature cells. It appears that the immediate administration of high-dose corticosteroids can favourably influence this condition. We consider that despite its greater risks daily treatment with rifampicin is to be preferred to discontinuous therapy because of its better tuberculostatic effect.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 50 (1972), S. 898-906 
    ISSN: 1432-1440
    Keywords: Blood pressure ; continuous direct measurement ; microcatheter technique ; radiotelemetry ; blood pressure in everday activities ; range of blood pressure alterations ; 24-hour blood pressure profile ; Blutdruck ; kontinuierliche direkte Messung ; Mikrokathetermethode ; Telemetrie ; „Alltags“-Blutdruck ; Ausmaß der Blutdruckschwankungen ; 24 Std-Blutdruck-Profil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird eine einfache, risikoarme, den Probanden nicht belastende Methode zur direkten kontinuierlichen blutdruckmessung und telemetrischen Übertragung beschrieben. An Hand typischer Anwendungsbeispiele läßt sich zeigen, daß mit dieser Methode sowohl die Erfassung rascher Blutdruckänderungen unter verschiedenen Bedingungen, als auch die genaue Registrierung eines „alltäglichen“ 24 Std-Blutdruckprofils möglich ist. Die Methode erscheint geeignet für grundlagen-bezogene Studien der Blutdruckrhythmik, wie für klinisch-pharmakologische Untersuchungsreihen. Verglichen mit herkömmlichen indirekten Messungen der Liege-und Steh-Blutdrucke könnte sich mit vorliegender Methode eine „neue Dimension“ in der Beurteilung des Blutdruckverhaltens eröffnen.
    Notes: Summary A simple, low-risk method causing little stress to the patient is described for direct continuous pressure measurement (percutaneous catheterization of the brachial artery) and radiotelemetric transmission. It is demonstrated that this permits to record rapid blood pressure changes under various conditions, as well as to establish an exact everyday-like 24-hour blood pressure profile. The method seems appropriate for studies of blood pressure rhythm as well as for clinical pharmacological examinations. Compared with the common indirect measurement of blood pressure in supine and standing position, a „new dimension“ in the evaluation of blood pressure reactions may be open with the method presented.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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