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  • Chronic hepatitis  (3)
  • intestinaleβ-Galactosidasen  (2)
  • 25-Hydroxyvitamin D  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Trennung der intestinalen β-Galactosidasen beim lactose-intoleranten Erwachsenen durch Ultrazentrifugation im Dichtegradienten (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 260-261 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Lactose intolerance ; intestinalβ-Galactosidases ; ultracentrifugation ; Lactose-Intoleranz ; intestinaleβ-Galactosidasen ; Ultrazentrifugation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Bei 11 erwachsenen Versuchspersonen mit Lactose-Intoleranz konnten bei der Trennung der intestinalenβ-Galactosidasen im Dichtegradienten die „neutrale“ Bürstensaum-Lactase und die „saure“ lysosomale Lactase nachgewiesen werden. Im Vergleich zu lactose-toleranten Erwachsenen war die Bürstensaum-Lactase stark vermindert. Die Hetero-β-Galactosidase, die bei lactose-toleranten Erwachsenen als langsam sedimentierendes Enzym nachweisbar ist, fehlte bei allen 11 Versuchspersonen.
    Notizen: Summary In 11 adult probands with lactose intolerance the intestinalβ-galactosidases were separated in a density gradient by ultracentrifugation. The “neutral” brush border lactase and the “acid” lysosomal lactase were identified in the biopsy material of all 11 subjects. In comparison with lactosetolerant adults the brush border lactase was markedly diminished. The hetero-β-galactosidase which is present as a slowly sedimenting enzyme in lactose-tolerant adults, was absent in all of the 11 subjects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01486533
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  • 2
    Digitale Medien
    Digitale Medien
    Trennung der intestinalen β-Galactosidasen beim lactose-toleranten Erwachsenen durch Ultrazentrifugation im Dichtegradienten (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 258-259 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Lactose tolerance ; intestinalβ-Galactosidases ; ultracentrifugation ; Lactose-Toleranz ; intestinaleβ-Galactosidasen ; Ultrazentrifugation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Die intestinalenβ-Galactosidasen von 4 lactose-toleranten, erwachsenen Mitteleuropäern wurden im Saugbiopsie-Gewebe nach Solubilisierung mit Triton X-100 in einem linearen Mannitol-Gradienten (5–20%) auf der Ultrazentrifuge bei 4°C und 44000 U/min getrennt. Bei 12stündiger Zentrifugation fanden sich 3 Fraktionen, von denen die beiden schneller sedimenticrenden Lactose spalten. Alle 3 Fraktionen hydrolysieren p-Nitrophenyl-β-Galactosid. Die 3 isoliertenβ-Galactosidasen entsprechen wahrscheinlich der „neutralen“ Bürstensaum-Lactase, der „sauren“ lysosomalen Lactase und einer cytoplasmatischen Hetero-β-Galactosidase.
    Notizen: Summary The intestinalβ-galactosidases in suction biopsy material of 4 lactose-tolerant adult Europeans were separated after solubilization with Triton X-100 in a linear 5–20% mannitol gradient by ultracentrifugation at 4°C and 44000 rpm. After a centrifugation time of 12 h 3 fractions were identified. The 2 fractions which sedimented more rapidly were active with lactose as substrate; all 3 fractions hydrolized p-nitrophenyl-β-galactoside. The 3 isolatedβ-galactosidases probably correspond to the “neutral” brush border lactase, the “acid” lysosomal lactase, and a cytoplasmatic hetero-β-galactosidase.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01486532
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  • 3
    Digitale Medien
    Digitale Medien
    25 Hydroxyvitamin D and vitamin E absorption in healthy children and children with chronic intrahepatic cholestasis (1989)
    Springer
    European journal of pediatrics 148 (1989), S. 605-609 
    Details
    ISSN: 1432-1076
    Schlagwort(e): 25-Hydroxyvitamin D ; 1,25-Dihydroxyvitamin D ; Vitamin E-Vitamin D binding protein ; Chronic cholestasis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Patients with chronic cholestasis have reduced 25-hydroxyvitamin D (25 OHD) and vitamin E levels. We determined serum concentrations of 25 OHD, 1,25-dihydroxyvitamin D [1,25(OH)2D] and vitamin E before and after oral administration of 10 μg/kg body weight 25-hydroxyvitamin D3 (25 OHD3) and 100 IU/kg body weight vitamin E, respectively, in 4 patients with intrahepatic cholestasis and 6 healthy children. Vitamin E increased in all controls but in only one of the four patients. In contrast, oral 25 OHD3 induced a normal rise in circulating 25 OHD and 1,25(OH)2D. The low serum levels of 25 OHD in the patients before the oral bolus may have been due to inadequate parenteral vitamin D administration and/or to the simultaneous phenobarbital treatment. The latter possibility is supported by the increase of serum 25 OHD into the normal range after withdrawal of phenobarbital in one of the four patients. We conclude that vitamin E has to be supplemented parenterally or in water-soluble oral form. Further studies are necessary to clarify whether high-dose long-term oral 25 OHD3 supplementation is sufficient to prevent vitamin D deficiency in patients with chronic cholestasis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00441510
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  • 4
    Digitale Medien
    Digitale Medien
    Chronic viral hepatitis B in childhood (1981)
    Springer
    European journal of pediatrics 136 (1981), S. 57-62 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Chronic hepatitis ; Chronic persistent hepatitis ; Chronic aggressive hepatitis ; Minimal hepatitis ; Immunoglobulins ; Autoantibodies ; Hepatitis B virus antigens ; DNA polymerase ; Immunofluorescent studies ; Viral antigen expression patterns ; Nonparenteral HBV infection
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The results of immunological studies in serum and liver tissue from 26 patients with chronic HBsAg-positive hepatitis (15 CPH, 9 CAH, 2 MinH) are presented. Determination of serum immunoglobulins showed no significant differences between the three categories of HBsAg-positive CH. AGF, ANA and AMA were not demonstrable in our patients. HBsAg and anti-HBc were demonstrated in all patients, HBeAg in 16, anti-HBe in 6 patients. 2 children had anti-HBs antibodies. Elevated DNA polymerase activity was found in 8 of 12 HBeAg-seropositive and 0 of 9 HBeAg-sero-negative patients. HBcAg was present in liver tissue from 9 of 10 HBeAg-seropositive and 1 of 9 HBeAg-seronegative children. In some cases the classification of viral antigen expression patterns according to the studies of Bianchi and Gudat did not correspond to the histological diagnosis and the presence of serum HBeAg. Studies in 51 family members of 23 children showed a high incidence of HBsAg carriers among the siblings and frequent evidence of anti-HBs in the mothers. Altogether, contact with HBV was demonstrated in 28 of the relatives studied.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00441712
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  • 5
    Digitale Medien
    Digitale Medien
    Chronic viral hepatitis B in childhood (1980)
    Springer
    European journal of pediatrics 135 (1980), S. 169-173 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Chronic hepatitis ; Chronic persistent hepatitis ; Chronic aggressive hepatitis ; Minimal hepatitis ; Hepatitis B virus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The results of clinical, biochemical and histological studies in 26 children with chronic hepatitis B are reported. Most cases were detected when diagnostic procedures were arranged because of non specific abdominal complaints, by routine tests after acute hepatitis or multiple transfusions, and by examination of family members. Hepatomegaly was found in half of the cases, splenomegaly in a quarter. Other clinical signs were rarely seen. Among the biochemical findings, elevated serum transaminase activities were the most reliable indicators of chronic hepatitis. There was a significant difference of the mean transaminase activities between patients with CPH and CAH. In 15 children CPH was diagnosed histologically. 9 children had CAH, 2 children showed signs of MinH.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00441637
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  • 6
    Digitale Medien
    Digitale Medien
    Correlation of hepatitis B virus, hepatitis D virus and human immunodeficiency virus type I infection markers in hepatitis B surface antigen positive haemophiliacs and patients without haemophilia with clinical and histopathological outcome of hepatitis (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 90-94 
    Details
    ISSN: 1432-1076
    Schlagwort(e): HDV infection ; Chronic hepatitis ; HIV infection ; Haemophilia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The hepatitis D virus (HDV) infection plays a major role in severe liver damage caused by hepatitis. To establish the prevalence of HDV infection in haemophilic patients and patients without haemophilia, 87 patients with chronic hepatitis B virus (HBV) infection were examined for serological evidence of delta hepatitis. In addition HBV, HDV and human immunodeficiency virus type 1 (HIV) infection markers were compared to clinical and histopathological outcome of hepatitis. Out of 46 haemophiliacs 30 (65%) were anti-HD-seropositive; 10 out of 30 anti-HD-positive patients (33%) had pathological liver function tests compared to 2 out of 16 anti-HD-negative haemophiliacs (13%). The rate of HIV infection did not differ between the HDV infected and the non-HDV infected individuals with haemophilia (17/27 anti-HD-positive patients versus 12/16 anti-HD-negative patients). Two haemophilic anti-HD-positive patients underwent liver biopsy, in both cases hepatitis D antigen (HDAg) was detected in the biopsies. Only 2 out of 41 patients without haemophilia were anti-HD-positive. Both had pathological liver function tests; chronic active hepatitis and cirrhosis, respectively, were diagnosed and HDAg was found in the liver biopsies. Out of 39 anti-HD-seronegative patients without haemophilia, 26 (67%) were hepatitis B e antigen positive; in the sera of 20 patients )51%) HBV-DNA was demonstrated, but only 6 patients (15%) had pathological liver function tests. In conclusion a high seroprevalence of HDV infection was found in haemophilic patients treated with non-pasteurized commercial clotting factor concentrates. An endemic spreading of HDV infection in patients without haemophilia with chronic HBV infection could not be detected. In haemophilic patients pathological liver function tests were more frequently associated with HDV superinfection than with chronic HBV infection alone. HIV infection was diagnosed at a similar rate in anti-HD-positive and anti-HD-negative patients.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01958949
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