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  • Analytical Chemistry and Spectroscopy  (5)
  • 25.70.Gh  (3)
  • cholesterol  (3)
  • Angiotensin  (2)
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  • 1
    Digitale Medien
    Digitale Medien
    On the separation of functions mediated by the AV3V region
    Amsterdam : Elsevier
    Peptides 3 (1982), S. 495-499 
    Details
    ISSN: 0196-9781
    Schlagwort(e): AV3V ; Angiotensin ; Diuresis ; Drinking responses ; Hypertonic saline ; Medial preoptic area ; Medial septum ; OVLT ; SFO
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0196-9781(82)90114-0
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  • 2
    Digitale Medien
    Digitale Medien
    Renin-dependent water intake in hypovolemia (1988)
    Springer
    Pflügers Archiv 412 (1988), S. 574-578 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Renin ; Angiotensin ; Thirst ; Hypovolemia ; Polyethleneglycol ; Saralasin ; Captopril ; Enalapril
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The role of the renin-angiotensin system as a mediator of water intake, induced by hypovolemia after polyethylene glycol (PEG) injection, was investigated. Blockade of angiotensin I converting enzyme and of angiotensin receptors was used as a pharmacological tool. A significant reduction of water intake was observed when angiotensin 1 converting enzyme was inhibited by captopril and enalapril. In PEG-treated rats with blockade of angiotensin I converting enzyme, hypertonic saline injection continued to elicit substantial drinking. Normalization of low blood pressure by vasopressin infusions in PEG and captopril treated rats did not interfere with the antidipsogenic effectiveness of converting enzyme blockade. The angiotensin II receptor antagonist, saralasin, also reduced PEG-induced drinking although less effectively than converting enzyme inhibitors. We conclude that water intake due to isotonic depletion of the extracellular fluid compartment may depend on the activity of the renin-angiotensin system.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00583757
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  • 3
    Digitale Medien
    Digitale Medien
    Alterations in apolipoprotein B-48 in the postprandial state in NIDDM (1994)
    Springer
    Diabetologia 37 (1994), S. 1259-1264 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Apolipoprotein B-48 ; triglyceride-rich lipoproteins ; NIDDM ; cholesterol ; triglyceride
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The intestine is a major site of cholesterol synthesis and produces apolipoprotein B-48, which is critical for intestinal cholesterol absorption and secretion. The purpose of this study was to examine postprandial changes in apolipoprotein B-48 in diabetes. Six non-insulin-dependent diabetic patients and six non-diabetic control subjects were given a high-fat meal (1300 kcal) and blood samples were taken pre- and postprandially, from which the triglyceride-rich lipoprotein fraction was isolated by ultracentrifugation (density〈1.006 g/ml). Apolipoprotein B-48 was separated on 4–15% gradient gels and quantified as a percentage of the fasting concentration by densitometric scanning. Total protein, triglyceride and cholesterol in the triglyceride-rich lipoprotein fraction, blood glucose, and serum insulin were also measured. Diabetic patients exhibited a postprandial triglyceride-rich apolipoprotein B-48 profile significantly different from that of control subjects (p〈0.05). The triglyceride and total protein concentration in the triglyceride-rich lipoprotein fraction mirrored the post-prandial profile and apolipoprotein B-48 in both groups. Significantly different patterns for triglyceride (p〈0.02) and total protein (p〈0.05) following the fat-rich meal were observed in the two groups. Fasting and postprandial triglyceride-rich lipoprotein cholesterol and total apolipoprotein B were significantly higher in diabetic patients than in control subjects (p〈0.05). Since apolipoprotein B-48 is the structural protein of intestinally-derived lipoprotein particles, these studies suggest an abnormality in intestinal lipoprotein metabolism in diabetes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00399800
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  • 4
    Digitale Medien
    Digitale Medien
    Alterations in apolipoprotein B-48 in the postprandial state in NIDDM (1994)
    Springer
    Diabetologia 37 (1994), S. 1259-1264 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Key words Apolipoprotein B-48 ; triglyceride-rich lipoproteins ; NIDDM ; cholesterol ; triglyceride.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The intestine is a major site of cholesterol synthesis and produces apolipoprotein B-48, which is critical for intestinal cholesterol absorption and secretion. The purpose of this study was to examine postprandial changes in apolipoprotein B-48 in diabetes. Six non-insulin-dependent diabetic patients and six non-diabetic control subjects were given a high-fat meal (1300 kcal) and blood samples were taken pre- and postprandially, from which the triglyceride-rich lipoprotein fraction was isolated by ultracentrifugation (density 〈 1.006 g/ml). Apolipoprotein B-48 was separated on 4–15 % gradient gels and quantified as a percentage of the fasting concentration by densitometric scanning. Total protein, triglyceride and cholesterol in the triglyceride-rich lipoprotein fraction, blood glucose, and serum insulin were also measured. Diabetic patients exhibited a postprandial triglyceride-rich apolipoprotein B-48 profile significantly different from that of control subjects (p 〈 0.05). The triglyceride and total protein concentration in the triglyceride-rich lipoprotein fraction mirrored the post-prandial profile and apolipoprotein B-48 in both groups. Significantly different patterns for triglyceride (p 〈 0.02) and total protein (p 〈 0.05) following the fat-rich meal were observed in the two groups. Fasting and postprandial triglyceride-rich lipoprotein cholesterol and total apolipoprotein B were significantly higher in diabetic patients than in control subjects (p 〈 0.05). Since apolipoprotein B-48 is the structural protein of intestinally-derived lipoprotein particles, these studies suggest an abnormality in intestinal lipoprotein metabolism in diabetes. [Diabetologia (1994) 37: 1259–1264]
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00399800
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  • 5
    Digitale Medien
    Digitale Medien
    Cellular cholesterol regulation — A defect in the Type 2 (non-insulin-dependent) diabetic patient in poor metabolic control (1990)
    Springer
    Diabetologia 33 (1990), S. 93-99 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Type 2 (non-insulin-dependent) diabetes mellitus ; LDL ; cholesterol ; esterification ; glycosylation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary This study investigates the relationship between Type 2 (non-insulin-dependent) diabetes mellitus and hypercholesterolaemia with regard to delivery of cholesterol to cells and regulation of endogenous cholesterol synthesis. The ability of LDL, from hypercholesterolaemic and Type 2 diabetic patients, to suppress cellular cholesterologenesis and to enhance mitogen-stimulated lymphocyte proliferation was compared. Cholesterol synthesis was estimated by measuring [14C]-acetate incorporation into cholesterol and lymphocyte proliferation was assessed by [3H]-thymidine incorporation into mitogen-stimulated normal lymphocytes. The results indicate that LDL from both Type 2 diabetic patients in poor metabolic control and hypercholesterolaemic patients was significantly less effective (p 〈 0.001) than LDL from non-diabetic normocholesterolaemic subjects in suppressing cholesterol synthesis in lymphocytes. LDL from all hypercholesterolaemic patients enhanced lymphocyte proliferation to a greater extent than LDL from normocholesterolaemic subjects and this effect was significantly increased using LDL from Type 2 diabetic, hypercholesterolaemic patients. Both suppression of [14C]-acetate incorporation and enhancement of [3H]-thymidine uptake could be related to an increased esterified/free cholesterol ratio in the LDL particle. The fact that cholesterol synthesis and cell proliferation were markedly altered by the above changes in LDL composition suggests a mechanism for cellular cholesterol accumulation in the Type 2 diabetic patient, even in the absence of elevated serum cholesterol levels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00401046
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  • 6
    Digitale Medien
    Digitale Medien
    Identification and spectroscopy of the108Te nucleus (1994)
    Springer
    The European physical journal 350 (1994), S. 3-4 
    Details
    ISSN: 1434-601X
    Schlagwort(e): 23.20.Lv ; 25.70.Gh ; 27.60.+j
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Excited states of 108 Te were populated in the 54 Fe + 58 Ni (270 MeV) reaction using the NORDBALL detector array equipped with charged-particle and neutron detector systems for reaction channel separation. Gamma rays belonging to the neutron deficient nucleus 108 Te were identified for the first time. On the basis of γγ-coincidence and angular correlation relations a level scheme was constructed with tentative spin and parity assignments. The structure of the nucleus is discussed in the framework of systematics of heavier Te nuclei.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01285042
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  • 7
    Digitale Medien
    Digitale Medien
    Excited states of111I and the observation of a 21 ns isomer (1994)
    Springer
    The European physical journal 350 (1994), S. 179-180 
    Details
    ISSN: 1434-601X
    Schlagwort(e): 23.20.Lv ; 25.70.Gh ; 27.60.+j
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Proton rich nuclei close to 100 Sn have been investigated inbeam using the NORDBALL detector array. A beam of 270 MeV58 Ni was used to bombard a 54 Fe target. Reaction channel separation was achieved with a 4π charged particle multi-detector set-up together with a 1π neutron detector wall placed in the forward direction. Gamma-ray transitions belonging to the 111 I nucleus were identified for the first time. A level scheme constructed from γ-γ-particle-coincidence analysis is proposed. The level structure is discussed within the framework of the shell model and the systematics of the heavier odd iodine nuclei.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01289577
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  • 8
    Digitale Medien
    Digitale Medien
    In-beamγ-ray spectroscopy of102In (1993)
    Springer
    The European physical journal 345 (1993), S. 243-244 
    Details
    ISSN: 1434-601X
    Schlagwort(e): 23.20.Lv ; 25.70.Gh ; 27.60.+j
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Neutron deficient nuclei close to 100Snhave been investigated in-beam by γ-ray spectroscopic methods using the NORDBALL detector array. A beam of 270 MeV 58Niwas used to bombard a target of 54Fe.Reaction channel separation was achieved with a 4π charged particle multidetector setup together with a 1π neutron detector wall placed in the forward direction. Excited states of 102Inwere identified for the first time. The level scheme constructed from γ-γ-particle-coincidence and γ-γ-angular correlation analysis is presented. The structure of 102 In is discussed and compared to neighboring nuclei in the framework of the nuclear shell-model.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01293351
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  • 9
    Digitale Medien
    Digitale Medien
    Raman spectroscopic determination of the dissociation constants of an acetonitrile-zinc complex in aqueous solution and the enthalpy and entropy of complex dissociation (1991)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 22 (1991), S. 651-656 
    Details
    ISSN: 0377-0486
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Physik
    Notizen: The dissociation constants for an acetonitrile-zinc complex, (CH3CN)Zn2+, were measured in aqueous solutions containing zinc salts (40-80%, w/w) and acetonitrile by Raman spectroscopy. Quantitative measurements of the intensity of the free and complexed ν(CN) Raman bands at 2264 and 2320 cm-1, respectively, were used to determine the average enthalpy and entropy of the complex dissociation to free acetonitrile in the temperature range 293-343 K for a 70% (w/w) solution of zinc chloride (0.052 mol) in an aqueous solution containing acetonitrile (0.024 mol); δH° and δS° values of 8.4 ± 0.5 kJ mol-1, respectively, were determined.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jrs.1250221110
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  • 10
    Digitale Medien
    Digitale Medien
    Fourier transform Raman spectroscopic study of hydrogen bonding in 2,5-dimercapto-1,3,4-thiadiazole using an environmental chamberThis paper is dedicated to Professor D. A. Long on the occasion of his 70th birthday. (1995)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 26 (1995), S. 617-622 
    Details
    ISSN: 0377-0486
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Physik
    Notizen: The bands at 2485 and 940 cm-1 observed in the Raman spectra of 2,5-dimercapto-1,3,4-thiadiazole represent the hydrogen-bonded ν(SH) stretching and δ(C-SH) in-plane bending modes, respectively. A quantitative study of the hydrogen bonding was carried out using intensity measurements of the bands assigned to the hydrogen-bonded and the free δ(C-SH) in-plane deformations at 940 and 919 cm-1, respectively, as a function of temperature. The Fourier transform (FT) Raman spectra were recorded over the temperature range 303-403 K using an environmental chamber fitted into the FT Raman sample compartment. The equilibrium constants between the free and the hydrogen-bonded molecules were determined over this temperature range and the average enthalpy for hydrogen-bond formation was obtained (ΔH° = -3.35 ± 0.2 kJ mol-1).
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jrs.1250260806
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