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  • Rat  (3)
  • 3-hydroxybutyric acid  (1)
  • 36.40. + d  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Elevated concentrations of the β-subunit of S100 protein in renal cell tumors in rats (1994)
    Springer
    Urological research 22 (1994), S. 251-255 
    Details
    ISSN: 1434-0879
    Schlagwort(e): S100 protein ; Rat ; Carcinogenesis ; Renal neoplasms
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Concentrations of α and β-subunits of S100 protein (S100-α and S100-β) in rat kidney neoplasms, including renal cell and mesenchymal tumors, were determined using a highly sensitive enzyme immunoassay, and both types immunohistochemically localized in tissue sections. Concentration of S100-α in each histological type of rat tumor were lower than in normal kidney, whereas levels of S100-β (mean±SE: 29.7±14.2 ng/mg protein, n=15) in renal cell tumors were significantly higher than in normal kidneys (0.55±0.06 ng/mg protein, n=7), or mesenchymal tumors (1.21±0.43 ng/mg protein, n=9). In normal rat kidney tissues S100-α was immunohistochemically positive in epithelial cells of the distal tubules, the thin limbs of loops of Henle, and the collecting ducts. No appreciable immunostaining for S100-β was found in any nephron segment. Both S100-α and S100-β were positive for renal cell tumors, indicating new appearance of the latter during renal carcinogenesis in rats.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00541902
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  • 2
    Digitale Medien
    Digitale Medien
    Elevated concentrations of γ-enolase in renal cell tumors in rats: similarity to renal cell carcinoma in man (1996)
    Springer
    Urological research 24 (1996), S. 375-379 
    Details
    ISSN: 1434-0879
    Schlagwort(e): Enolase ; Isozymes ; Rat ; Renal neoplasms
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Concentrations of enolase isozymes in normal kidney and renal cell tumors in rats were determined using a highly sensitive enzyme immunoassay, and the isozymes were immunohistochemically localized in tissue sections. Levels of α-enolase in renal cell turnors were significantly lower than in normal kidney, whereas those of γ-enolase were significantly elevated (mean ±SD:211±129 ng/mg protein, n=15, as compared to 27.1±2.9 ng/mg protein, n=7). The proportion of γ-enolase in the total enolases in the tumor tissues (1.6±0.5%) was significantly higher than in normal kidney (0.15±0.005). Immunohistochemistry revealed epithelial cells of all nephron segments to be positive for the α-isozyme, whereas γ-enolase staining was strongly positive only in the loops of Henle, being faint in the distal tubules and absent in the proximal tubules. Both α- and γ-enolases demonstrated positive immunostaining in all of the seven renal cell tumors studied. These findings indicate that an isozyme switch from α- to γ-enolase occurs during rat kidney carcinogenesis, taking into account the derivation from proximal tubules, consistent with the findings for renal cell carcinomas in man.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00389796
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  • 3
    Digitale Medien
    Digitale Medien
    Elevated concentrations of the small stress protein HSP27 in rat renal tumors (1997)
    Springer
    Urological research 25 (1997), S. 173-177 
    Details
    ISSN: 1434-0879
    Schlagwort(e): αB crystallin ; Heat shock protein ; Rat ; Kidney neoplasms
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The expression of two small stress proteins, αB crystallin and the 27-kDa heat shock protein (HSP27), was studied quantitatively and immunohistochemically in normal kidney and renal tumors in rats. Levels of αB crystallin in renal cell tumors tended to be higher than in normal kidney (P = 0.07), but with a wide range of values, whereas they were significantly lower in mesenchymal tumors (P 〈 0.0001). In contrast, HSP27 concentrations in both renal cell (mean ± SD: 1790 ± 940 ng/mg protein,n = 15) and mesenchymal (1260 ± 1080 ng/mg protein,n = 10) tumors were significantly higher than the normal kidney value (142 ± 30 ng/mg protein,n = 10,P 〈 0.0001). A positive correlation was found between αB crystallin and HSP27 levels limited to the renal cell tumor case (Pearson's correlation coefficient,r = 0.68,P 〈 0.01). Immunohistochemistry revealed the loops of Henle to be positive for αB crystallin, whereas HSP27 staining was positive in glomerular and interstitial vascular walls and epithelial cells of proximal and distal tubules. Positive immunostaining for αB crystallin was demonstrated in six of nine renal cell tumors (67%) studied and for HSP27 in all of the nine cases (100%).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00941978
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  • 4
    Digitale Medien
    Digitale Medien
    Alpha-amylase inhibitor increases plasma 3-hydroxybutyric acid in food-restricted rats (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 585-588 
    Details
    ISSN: 1420-9071
    Schlagwort(e): α-amylase inhibitor ; plasma glucose ; 3-hydroxybutyric acid ; high starch diet
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract The effect on energy metabolism of delayed absorption of starch by inhibition of α-amylase was examined by considering levels of plasma glucose and 3-hydroxybutyric acid (3-OHBA) in rats. Addition of α-amylase inhibitor (αAI) to a high starch diet delayed the plasma glucose response after feeding: peak plasma glucose levels in the control group occurred 15 min after feeding, whereas in the αAI group this peak did not occur until 30 min after. The total plasma glucose response was not different between the two groups. Plasma 3-OHBA levels 1 day after food restriction increased approximately five-fold in both groups. After 3 days of food restriction, the αAI group maintained the same level of plasma 3-OHBA as after 1 day of food restriction, while the control group showed significantly decreased levels of 3-OHBA. After 3 days of food restriction, plasma insulin levels were significantly decreased in the αAI group compared with the corresponding levels of the control group and with levels before the restriction. There was no significant difference in body weight between the two groups. These findings suggest that delayed hyperglycemia due to delayed absorption of starch following αAI loading may attenuate insulin secretion, leading to altered metabolism of 3-OHBA during the delayed response to energy deficit.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02128748
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  • 5
    Digitale Medien
    Digitale Medien
    Structure of nm-sized InSb clusters formed by spontaneous alloying (1994)
    Springer
    The European physical journal 31 (1994), S. 209-212 
    Details
    ISSN: 1434-6079
    Schlagwort(e): 61.16.Di ; 36.40. + d ; 66.30. − h
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The alloying behavior of antimony atoms into nm-sized indium clusters has been studied in situ by TEM. When antimony atoms are vapor-deposited onto nm-sized indium clusters, a rapid dissolution of antimony atoms into indium clusters takes place and as a result InSb compound clusters are successfully formed. Such spontaneous alloying occurs even at ambient temperature. InSb clusters thus formed have the wurtzite structure. When these InSb clusters are annealed at 533 K, their structure changes into the sphalerite structure, which is the structure of the equilibrium phase of the bulk In50Sb50. The appearance of wurtzite-type InSb by spontaneous alloying is discussed in terms of ionicity of bonds in InSb.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01437838
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