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  • 1
    Electronic Resource
    Electronic Resource
    Expression of CD69 on T-cells from HIV-1-infected children and adolescents increases with increasing viral load (1999)
    Springer
    European journal of pediatrics 158 (1999), S. 638-644 
    Details
    ISSN: 1432-1076
    Keywords: Key words HIV-1 ; T-cells ; CD69 ; Activation ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated the use of a whole-blood assay that measures spontaneous and activation-induced CD69 expression on peripheral blood T-cells in vitro for assessment of T-cell function in HIV-1-infected paediatric patients. Heparinized venous blood from 28 HIV-1 positive children and adolescents and 23 healthy controls was incubated for 4 h with or without 5 μg/ml phytohaemagglutinin (PHA). Thereafter, analysis of CD69 expression on CD4+ and CD8+ T-cells was done by flow cytometry; simultaneously we determined CD4+ T-cell counts and plasma HIV-1 viral load. Neither spontaneous nor PHA-induced CD69 expression differed significantly between HIV-1 positive patients and healthy controls. However, T-cells from HIV-1 positive patients with plasma HIV-1 viral load levels above 70 × 103 copies/ml showed a higher spontaneous CD69 expression than T-cells from patients with lower plasma viral load levels in different stages of the disease. Antiretroviral treatment in four patients reduced spontaneous CD69 expression in CD4+ T-cells and PHA-induced CD69 expression in CD4+ and CD8+ T-cells significantly after 8 weeks of therapy. Conclusion Spontaneous and activation-induced expression of the early (activation) antigen CD69 on peripheral blood T-cells does not distinguish HIV-1 positive patients from HIV-1 negative healthy controls and is not correlated with peripheral blood CD4+ T-cell counts. This test may not be a reliable marker for functional T-cell deficiency during early stages of HIV disease. Increased spontaneous as well as PHA-induced CD69 expression on T-cells from HIV-1-infected children and adolescents in vitro may rather reflect HIV-induced pre-activation of T-cells in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310051167
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  • 2
    Electronic Resource
    Electronic Resource
    139. Verbesserung der Organqualität bei der Nierenspende (1981)
    Springer
    Langenbeck's archives of surgery 355 (1981), S. 530-530 
    Details
    ISSN: 1435-2451
    Keywords: Kidney donation ; Donor procurement ; En-bloc perfusion ; Nierenspende ; organerhaltende Therapie ; En-bloc Perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Neben immunologischen Faktoren nimmt die Organqualität bei der Nierenspende eine Schlüsselposition für den Transplantationserfolg ein. Anhand von 110 Organentnahmen werden die wesentlichen organisatorischen und intensivmedizinischen Maßnahmen sowie die in Münster weiterentwickelte extracorporale transaortale Nierenperfusion dargestellt.
    Notes: Summary Besides immunological problems the anatomical and functional integrity of the transplanted kidney has a decisive influence on the outcome of kidney grafting. Using the data obtained from 110 kidneys explanted in Münster, we outline the essential regimen of donor procurement in an intensive care unit. A sophisticated technique in terms of extracorporeal transaortic en bloc graft perfusion is offered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01286969
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  • 3
    Electronic Resource
    Electronic Resource
    Fine structure and hyperfine structure in the excited configuration 5p 26s of the antimony I spectrum (1986)
    Springer
    The European physical journal 1 (1986), S. 151-156 
    Details
    ISSN: 1434-6079
    Keywords: 32.90 ; 32.30 ; 35.10
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract By optical interference and VUV spectroscopy the doublet system of SbI 5p 26s was investigated, so that now the hyperfinestructure of all 8 levels of 5p 26s (A- andB-splitting constants) are known. From the analysis we receive a spin-orbit parameter ζ5p =3,538(57) cm−1 and from the hyperfine-analysis single electron splitting constantsa 5p 01 =52.4(4.6),a 5p 10 =−1.6(7.3),a 5p 12 =72.3(2.3),a 6s 10 =91.7(4.1),b 5p 02 =−49.6(1.1) andb 5p 11 =30.4(3.2) (all values in mK). For all calculations in the fs- and hfs-analysis the 5p 26s 2 D 3/2 has to be excluded (see discussion). With the figures given above the quadrupole moment121 Q(5p 26s)=−0.44(3) barn was obtained. It is in good agreement with the121 Q(5p 3). For the core-polarization by the 5p electron in the innerfieldns-shells (n=1, 2, 3, 4, 5) and the unpaired 6s electron a field of +500(300) kG was obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01436548
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    Paper (German National Licenses)
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