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  • 5-Fluorouracil  (1)
  • Hirschsprung's disease  (1)
  • ac losses  (1)
  • computing methods  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 15 (1999), S. 141-142 
    ISSN: 1437-9813
    Keywords: Key words Colonic atresia ; Hirschsprung's disease ; Complications Diagnosis ; Anastomosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of colonic atresia (CA) and aganglionosis is presented, which is probably the tenth in the English literature. The boy presented on day 3 of life with delayed passage of meconium, milk intolerance, and progressive abdominal distension. A barium enema study was complicated by barium peritonitis. Emergency peritoneal lavage was done and the intestinal obstruction was relieved by a proximal defunctioning ileostomy; type III CA (Grosfeld classification) was identified. The proximal atretic end was the blind-ending caecum and the distal atretic end commenced in the splenic area as a microcolon extending to the pelvis and replacing the normal colon. Total colonic aganglionosis (TCA) was confirmed by biopsies. This is the first case in the literature of TCA with CA documented before any attempts at colonic resection and anastomosis were made. This association highlights the recommendation for biopsy of the micro-colon and rectum when Type III CA (Grosfeld classification) is encountered in a newborn. The infant underwent a cholecystectomy and Duhamel-Martin operation at 14 months that was complicated by abdominal wound dehiscence; the ileostomy was closed at 22 months of age.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0843
    Keywords: Key words Carboplatin ; 5-Fluorouracil ; Metastatic nasopharyngeal carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A carboplatin and 5-fluorouracil (CF) chemotherapy protocol was designed to evaluate tumor response and toxicity in patients with metastatic nasopharyngeal carcinoma (NPC). Patients with metastatic NPC were treated with a maximum of eight courses of CF. Carboplatin was given at 300 mg/m2 by intravenous bolus on day 1 and 5-fluorouracil at 1 g/m2 per day by continuous infusion on days 1 – 3; cycles were repeated once every 3 weeks. A total of 42 patients were evaluable for response and toxicity. They received a median of 6 courses (range 2 – 8) of chemotherapy. The overall response rate was 38% (16/42), comprising 7 complete responses (CR, 17%) and 9 partial responses (PR, 21%). The median survival was 12.1 months (range 6 – 54.2 months). The treatment was well tolerated. Toxicity was mainly bone marrow suppression. There were four episodes of neutropenic fever, but no renal toxicity or treatment-related death was documented. The combination of carboplatin given at a fixed dose of 300 mg/m2 for 1 day and 5-fluorouracil given at 1 g/m2 per day for 3 days produced an objective response rate of 38% and tolerable side effects.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1572-9605
    Keywords: Superconductivity ; ac losses ; Y-Ba-Cu-O ; Tl-Ca-Ba-Cu-O
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract We have used a novel bolometric technique and a resonant technique to obtain accurate submillimeter and microwave residual loss data for epitaxial thin films of YBa2Cu3O7, Tl2Ca2Ba2Cu3O10, and Tl2CaBa2Cu2O8. For all films we obtain good agreement between the submillimeter and microwave data, with the residual losses in both the Y-Ba-Cu-O and Tl-Ca-Ba-Cu-O films scaling approximately as frequency squared below ∼1 THz. We are able to fit the losses in the Y-Ba-Cu-O films to a weakly coupled grain model for thea-b plane conductivity, in good agreement with results from a Kramers-Kronig analysis of the loss data. We observe strong phonon structure in the Tl-Ca-Ba-Cu-O films for frequencies between 2 and 21 THz, and are unable to fit these losses to the simple weakly coupled grain model. This is in strong contrast to the case for other high-T c superconductors such as YBa2Cu3O7, where phonon structure observed in ceramic samples is absent in epitaxial oriented films and crystals because of the electronic screening due to the high conductivity of thea-b planes.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 52 (1987), S. 1-24 
    ISSN: 1573-2878
    Keywords: Orbital transfer ; coplanar orbital transfer ; aeroassisted orbital transfer ; transfer between circular orbits ; grazing trajectories ; nearly-grazing trajectories ; optimal trajectories ; lift modulation ; Bolza problems ; Chebyshev problems ; minimax problems ; numerical methods ; computing methods ; transformation techniques ; sequential gradient-restoration algorithm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract This paper considers both classical and minimax problems of optimal control which arise in the study of aeroassisted, coplanar orbital transfer. The maneuver considered involves the coplanar transfer from a high planetary orbit to a low planetary orbit. An example is the HEO-to-LEO transfer of a spacecraft, where HEO denotes high Earth orbit and LEO denotes low Earth orbit. In particular, HEO can be GEO, a geosynchronous Earth orbit. The basic idea is to employ the hybrid combination of propulsive maneuvers in space and aerodynamic maneuvers in the sensible atmosphere. Hence, this type of flight is also called synergetic space flight. With reference to the atmospheric part of the maneuver, trajectory control is achieved by means of lift modulation. The presence of upper and lower bounds on the lift coefficient is considered. Within the framework of classical optimal control, the following problems are studied: (P1) minimize the energy required for orbital transfer; (P2) minimize the time integral of the heating rate; (P3) minimize the time of flight during the atmospheric portion of the trajectory; (P4) maximize the time of flight during the atmospheric portion of the trajectory; (P5) minimize the time integral of the square of the path inclination; and (P6) minimize the sum of the squares of the entry and exit path inclinations. Problems (P1) through (P6) are Bolza problems of optimal control. Within the framework of minimax optimal control, the following problems are studied: (Q1) minimize the peak heating rate; (Q2) minimize the peak dynamic pressure; and (Q3) minimize the peak altitude drop. Problems (Q1) through (Q3) are Chebyshev problems of optimal control, which can be converted into Bolza problems by suitable transformations. Numerical solutions for Problems (P1)–(P6) and Problems (Q1)–(Q3) are obtained by means of the sequential gradient-restoration algorithm for optimal control problems. The engineering implications of these solutions are discussed. In particular, the merits of nearly-grazing trajectories are considered.
    Type of Medium: Electronic Resource
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