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  • 8-threonine angiotensin II  (1)
  • Chemistry  (1)
  • pancreatic polypeptide  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of three angiotensin II antagonists, [Sar1, Thr8]-, [Sar1, Ile8]-and [Sar1, Ala8]angiotensin II on blood pressure and endocrine factors in normal subjects (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 7-10 
    Details
    ISSN: 1432-1041
    Keywords: angiotensin II analogues ; angiotensin II receptors ; 1-sarcosine ; 8-threonine angiotensin II ; 1-sarcosine ; 8-isoleucine angiotensin II ; 1-sarcosine ; 8-alanine angiotensin II ; blood pressure ; plasma aldosterone concentration ; plasma renin activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The biological effects of 1-Sarcosine, 8-Threonine angiotensin II ([Sar1, Thr8]ANG II) on blood pressure, plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were investigated in six normal subjects on an unrestricted diet, and compared with those of 1-Sarcosine, 8-Isoleucine ANG II ([Sar1, Ile8]ANG II) and 1-Sarcosine, 8-Alanine ANG II ([Sar1, Ala8]ANG II). All three ANG II analogues (A II A) showed agonistic pressor activity, that of [Sar1, Ile8]ANG II being greater than that of [Sar1, Thr8]ANG II or [Sar1, Ala8]ANG II. The antagonistic effect of [Sar1, Thr8]ANG II on blood pressure was less than [Sar1, Ile8]ANG II or [Sar1, Ala8]ANG II. Both [Sar1, Ile8]ANG II and [Sar1, Ala8]ANG II increased PAC and blocked the steroidogenic action of ANG II, while [Sar1, Thr8]ANG II showed little effect on PAC. All three A II A caused similar suppression of PRA and showed no inhibitory effect on the decrease in PRA produced by ANG II. These results indicate that [Sar1, Thr8] ANG II is an A II A with weak agonistic pressor action and that it has vascular selective properties. It is also suggested that ANG II receptors in a variety of target organs are heterogeneous.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01061369
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of trimebutine maleate on emptying of stomach and gallbladder and release of gut peptide following a solid meal in man (1993)
    Springer
    Digestive diseases and sciences 38 (1993), S. 817-823 
    Details
    ISSN: 1573-2568
    Keywords: trimebutine maleate ; solid meal ; gastric emptying ; gallbladder emptying ; pancreatic polypeptide ; gastrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the effect of orally administered trimebutine maleate on gastric and gallbladder emptying and on the release of gut peptide, pancreatic polypeptide (PP), and gastrin in humans for 120 min after ingestion of a solid meal. Gastric emptying was measured by a radionuclide technique. Gallbladder emptying was estimated by real-time ultrasonography. The oral administration of 200 mg of trimebutine maleate significantly shortened the lag time in starting gastric emptying (P〈0.05). Considering gallbladder emptying, trimebutine significantly inhibited the fasting emptying induced by neural reflex. Postprandially, there was a tendency toward an accelerated gallbladder emptying in the early phase. Neither the maximal percentage of gallbladder emptying nor the time of peak gallbladder emptying were affected. Trimebutine significantly blunted the postprandial PP response in the cephalic and gastric phases, reflecting a vagal-cholinergic activity (P〈0.05). The PP response in the intestinal phase was also blunted. Gastrin release was significantly augmented only during the period of fasting after drug administration (P〈0.05). The major effect of trimebutine maleate appears to be a shortening of the lag time at the start of gastric emptying probably via its anticholinergic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01295906
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  • 3
    Electronic Resource
    Electronic Resource
    Phase separation temperatures in the ternary system polystyrene/poly(α-methyl styrene)/cyclopentane (1986)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 24 (1986), S. 325-335 
    Details
    ISSN: 0887-6266
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Phase separation temperatures of the ternary system polystyrene (PS) (Mw = 1.67 × 104)/poly(α-methyl styrene) (PαMS) (Mw = 9.0 × 104)/cyclopentane with a blend ratio PS/PαMS = 55/45 have been determined over the polymer concentration range 0.02 ≤ ψPS + PαMS ≤ 0.52, where ψ PS + PαMS is the segment fraction of polymer in ternary system. Phase separation temperatures for the upper critical separation in the ternary system decrease with increasing ψ PS + PαMS over the range 0.1 ≤ ψ PS + PαMS ≤ 0.52. The vapor - liquid equilibrium in this system with a blend ratio PS/PαMS=50/50 has been determined over the concentration range 0.925 ≤ ψPS + PαMS 〈 0.995 and the temperature range 60-100°C by the piezoelectric vapor sorption method. The polymer - polymer interaction parameters χ′12 determined are positive except at 100°C and increase with increasing ψ PS + PαMS. Values of χ′12 extrapolated to zero solvent concentration are positive (0.0-1.3) over the temperature range measured. Phase separation behavior is discussed in terms of phase separation temperature in a ternary system and the polymer-polymer interaction parameter.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/polb.1986.090240209
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    Paper (German National Licenses)
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