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  • Chemistry  (2)
  • Non-functioning adenoma  (2)
  • AT877  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Lectin-binding sites of the human pituitary adenoma cells by means of the ferritin-labeling technique (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 67-74 
    Details
    ISSN: 1432-0533
    Keywords: Ferritin labeled lectin ; Human pituitary adenoma ; Functioning adenoma ; Non-functioning adenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lectin-binding sites of the human pituitary adenoma cells were examined by electron microscopy in correlation with their functional states. In this study used were 37 cases of the human pituitary adenomas which had been operated in our clinics from 1977 to 1979. They were divided into four groups: 13 cases of PRL-producing adenomas, nine of hGH-producing adenomas, three of ACTH-producing adenomas, and 12 of hormonal non-functioning adenomas. In parallel with the detection of the lectinbinding sites by means of the ferritin-labeling method, the basal levels of their secreting hormones were determined by the radioimmunoassay technique, and their producing hormones were characterized light microscopically by the immunocytochemical HRP-labeling technique. The present study clearly shows that the ferritinlabeled, lectin-binding sites of the human pituitary adenoma cells prefixed with aldehyde are different in number between PRL- or hGH-producing adenoma cells and non-functioning ones. Morphologically resemblin, non-functioning adenoma cells and mixed somatotrophic and lactotrophic adenoma cells are definitely distinguished from each other by the findings of the ferritin-labeled RCA-binding sites' distribution pattern. Lectins have been proved very useful to evaluate the membrane characteristics of the human pituitary adenoma cells in association with their functional states.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691184
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Dose escalation trial of a novel calcium antagonist, AT877, in patients with aneurysmal subarachnoid haemorrhage (1990)
    Springer
    Acta neurochirurgica 107 (1990), S. 11-15 
    Details
    ISSN: 0942-0940
    Keywords: Subarachnoid haemorrhage ; chronic cerebral vasospasm ; calcium antagonist ; AT877 ; HA 1077
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The initial dose-escalating clinical trial of a novel calcium antagonist, AT877, in patients with aneurysmal subarachnoid haemorrhage is reported. AT877 is characterized by its strong spasmolytic activity, its inhibition of intracellular calcium ion activity, and the inhibiton of several protein kinases. A total of 113 patients (Hunt and Hess grades I to IV) who had undergone surgery within 3 days of aneurysmal rupture entered the study. Patients were divided into 5 groups according to the total daily dose of AT877: I: 20 mg; II: 40 mg; III: 60 mg; IV: 90 mg; and V: 120–180 mg. AT877 was given by intravenous infusion over 30 min two or three times a day for 14 days after surgery. Although AT877 did not completely abolish angiographic vasospasm, severe vasospasm was seen less frequently in patients given higher doses. Vasospasm was the cause of a poor clinical outcome (Glasgow outcome scale rating 3 or greater) in 19%, 7%, 9%, 8%, and 6% of the patients in groups I to V, respectively. The results indicated a favourable clinical effect of AT877 at doses above 40 mg per day. Only mild hypotension was seen, even when 60 mg of AT877 was infused over 30 min. AT877 appears to be effective in patients with subarachnoid haemorrhage. Part of its effect may be attributable to protection of the brain from ischaemic insults due to chronic cerebral vasospasm. However, the drug still needs to be evaluated in a placebo-controlled double-blind trial (which is currently being carried out).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402606
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  • 3
    Electronic Resource
    Electronic Resource
    Localization of concanavalin A binding sites in human pituitary adenoma cells as revealed by HRP-labelling method (1983)
    Springer
    Acta neuropathologica 62 (1983), S. 59-66 
    Details
    ISSN: 1432-0533
    Keywords: Horseradish peroxidase ; Concanavalin A ; Human pituitary adenoma ; Functioning adenoma ; Non-functioning adenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracellular lectin (Con A)-binding sites of human pituitary adenoma were examined by electron microscopy using the horseradish-peroxidase (HRP)-labelling technique. In this study were used 16 cases of human pituitary adenomas operated on in our clinics between 1977 and 1981: they concluded 4 each of PRL-, GH-, ACTH-producing and hormonal non-functioning adenomas. In parallel with the detection of lectin-binding sites, basal levels of their secreting hormones were determined by the radioimmunoassay technique, and their producing hormones were characterized light microscopically by the immunocytochemical HRP-labelling technique. In the present study, for hormonal functioning adenoma cells, mature or large granules of each specific type of adenoma cells had no definite Con A-binding sites. On the other hand, immature or small secretory granules of RPL- or GH-producing adenoma cells showed a positive reaction with Con A. ACTH-producing adenomas so far examined revealed no definite binding sites. Some variable results were obtained concerning non-functioning adenomas. Lectins have been and will be very useful in the detection of different subtypes of adenomas in each specific group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684921
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Radical-induced ionic polymerization in the presence of maleic anhydride. II. Cationic polymerization of 1,2-butylene oxide by benzoyl peroxide and α,α′-azobisisobutyronitrile in the presence of maleic anhydride (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 18 (1974), S. 3653-3660 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The cationic polymerization of 1,2-butylene oxide initiated by radical catalysts has been investigated in detail in the presence of maleic anhydride. The active species of this ionic polymerization was thought to be a conjugated radical of poly(maleic anhydride).
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1974.070181212
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  • 5
    Electronic Resource
    Electronic Resource
    Radical-induced ionic polymerization in the presence of maleic anhydride. III. Polymerization of isobutyl vinyl ether initiated by trapped radicals in poly(maleic anhydride) (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 18 (1974), S. 3661-3670 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: In a previous paper1 it was mentioned that trapped radicals in poly(maleic anhydride) (Poly-MAH) have the ability to initiate cationic polymerization. In this paper, the cationic polymerization of isobutyl vinyl ether (IBVE) is described using Poly-MAH as the initiator. These radicals show different behavior during polymerization depending upon their structure. In particular, large conjugated radicals initiate ionic polymerizations.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1974.070181213
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    Paper (German National Licenses)
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