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  • Coeliac disease  (2)
  • Minimal hepatitis  (2)
  • Activated serum creatine phosphokinase  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Identifizierung heterozygoter Genträgerinnen der rasch progredienten recessiv X-chromosomalen Muskeldystrophie (Typ Duchenne) (1973)
    Springer
    European journal of pediatrics 115 (1973), S. 333-342 
    Details
    ISSN: 1432-1076
    Keywords: Muscular dystrophy (Duchenne type) ; Carrier identification ; Activated serum creatine phosphokinase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über Ergebnisse der SH-aktivierten CPK-Bestimmung im Serum von 84 Konduktorinnen der Muskeldystrophie Typ Duchenne berichtet. Es handelt sich um 6 sichere, 5 wahrscheinliche und 73 mögliche, Konduktorinnen. 83% der sicheren, 60% der wahrscheinlichen und 37% der möglichen Konduktorinnen zeigten erhöhte CPK-Aktivitäten im Serum.
    Notes: Abstract SH-activated serum-CPK has been estimated in 84 carriers of X-linked muscular dystrophy type Duchenne. The series includes 6 definite, 5 probable and 73 possible carriers. In 83% of the definite, 60% of the probable and 37% of the possible carriers serum-CPK activities were elevated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00438745
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chronic viral hepatitis B in childhood (1981)
    Springer
    European journal of pediatrics 136 (1981), S. 57-62 
    Details
    ISSN: 1432-1076
    Keywords: Chronic hepatitis ; Chronic persistent hepatitis ; Chronic aggressive hepatitis ; Minimal hepatitis ; Immunoglobulins ; Autoantibodies ; Hepatitis B virus antigens ; DNA polymerase ; Immunofluorescent studies ; Viral antigen expression patterns ; Nonparenteral HBV infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The results of immunological studies in serum and liver tissue from 26 patients with chronic HBsAg-positive hepatitis (15 CPH, 9 CAH, 2 MinH) are presented. Determination of serum immunoglobulins showed no significant differences between the three categories of HBsAg-positive CH. AGF, ANA and AMA were not demonstrable in our patients. HBsAg and anti-HBc were demonstrated in all patients, HBeAg in 16, anti-HBe in 6 patients. 2 children had anti-HBs antibodies. Elevated DNA polymerase activity was found in 8 of 12 HBeAg-seropositive and 0 of 9 HBeAg-sero-negative patients. HBcAg was present in liver tissue from 9 of 10 HBeAg-seropositive and 1 of 9 HBeAg-seronegative children. In some cases the classification of viral antigen expression patterns according to the studies of Bianchi and Gudat did not correspond to the histological diagnosis and the presence of serum HBeAg. Studies in 51 family members of 23 children showed a high incidence of HBsAg carriers among the siblings and frequent evidence of anti-HBs in the mothers. Altogether, contact with HBV was demonstrated in 28 of the relatives studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441712
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Antiretikulin-Antikörper und präcipitierende Antikörper gegen Nahrungsmittelproteine im Serum von Kindern mit Cöliakie (1976)
    Springer
    European journal of pediatrics 121 (1976), S. 215-226 
    Details
    ISSN: 1432-1076
    Keywords: Coeliac disease ; Antireticulin antibodies ; Precipitating antibodies to wheat flour ; Precipitating antibodies to cow's milk
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Antiretikulin-Antikörper im Serum wurden mit der Methode der indirekten Immunfluorescenz an frischen Rattennierenschnitten bei 11/13 Kindern (85%) mit florider Cöliakie, 7/17 Kindern (41%) mit klinisch und biochemisch stummem, bioptisch nachgewiesenem Cöliakie-Rezidiv und 0/16 Kindern mit behandelter Cöliakie nachgewiesen. Präcipitierende Antikörper im Serum gegen Weizenmehl bzw. Kuhmilch wurden mit Hilfe einer Kombination aus Elektrophorese und Immundiffusion bei 3/13 Kindern (23%) bzw. 2/13 Kindern (15%) mit florider Cöliakie und bei 1/16 Kindern (6%) mit behandelter Cöliakie gefunden. Bei den 17 Kindern mit stummem Cöliakie-Rezidiv fiel die Untersuchung auf präcipitierende Antikörper negativ aus. 40 Kontrollkinder wiesen weder Antiretikulin-Antikörper noch präcipitierende Antikörper gegen Weizenmehl oder Kuhmilch auf. Die Bedeutung des Antiretikulin-Antikörper-Nachweises für Screening-Untersuchungen und für die Verlaufskontrolle wird diskutiert.
    Notes: Summary Sera from 41 children suffering with histologically proven coeliac disease and from 40 healthy control children were investigated for the presence of antireticulin antibodies and precipitating antibodies to a watery extract of wheat flour and to cow's milk. Antireticulin antibodies were demonstrated by means of indirect immunofluorescence using sections of fresh rat kidney as substrat. For the detection of precipitating antibodies a combination of electrophoresis and immunodiffusion was used. Serum antireticulin antibodies were found in 11/13 children (85%) with active coeliac disease, in 7/17 children (41%) with clinically and biochemically silent coeliac relapse and in 0/16 children with treated coeliac disease. Serum precipitating antibodies to wheat flour and cow's milk were found respectively in 3/13 children (23%) and 2/13 children (15%) with active coeliac disease and in 1/16 children (6%) with treated coeliac disease. Precipitating antibodies could not be detected in the sera of 17 patients with silent relapse of coeliac disease. In the sera of 40 controls neither antireticulin nor precipitating antibodies were detectable. The presence of antireticulin antibodies in serum did not correspond to the presence of serum precipitins to wheat flour and cow's milk. The significance of serum antireticulin antibodies for sereening investigations and for follow-up studies is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445484
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Complement studies in children with treated coeliac disease after gluten challenge (1980)
    Springer
    European journal of pediatrics 134 (1980), S. 145-148 
    Details
    ISSN: 1432-1076
    Keywords: Complement ; Gluten ; Coeliac disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Changes of the complement components in the sera of 13 children with treated coeliac disease were studied after gluten challenge. The levels of C 1 and C 3-activator (factor B) were significantly decreased at 4 h after the challenge, as were the levels of total complement (CH 50) and the components C 1, C 4 and C 1-inactivator at 8 h. After 24 h most values returned to normal but there was another significant decrease in serum C 4 after 24 h, and for CH 50, C 1, C 2 and C 4 after 48 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01846034
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Chronic viral hepatitis B in childhood (1980)
    Springer
    European journal of pediatrics 135 (1980), S. 169-173 
    Details
    ISSN: 1432-1076
    Keywords: Chronic hepatitis ; Chronic persistent hepatitis ; Chronic aggressive hepatitis ; Minimal hepatitis ; Hepatitis B virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The results of clinical, biochemical and histological studies in 26 children with chronic hepatitis B are reported. Most cases were detected when diagnostic procedures were arranged because of non specific abdominal complaints, by routine tests after acute hepatitis or multiple transfusions, and by examination of family members. Hepatomegaly was found in half of the cases, splenomegaly in a quarter. Other clinical signs were rarely seen. Among the biochemical findings, elevated serum transaminase activities were the most reliable indicators of chronic hepatitis. There was a significant difference of the mean transaminase activities between patients with CPH and CAH. In 15 children CPH was diagnosed histologically. 9 children had CAH, 2 children showed signs of MinH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441637
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    Paper (German National Licenses)
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