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  • Breast cancer  (7)
  • Chemistry  (3)
  • Acute cardiac toxicity  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The clinical course of lung metastases from breast cancer (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 790-795 
    Details
    ISSN: 1432-1440
    Keywords: Breast cancer ; Lung metastases ; Clinical course
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinical course of 50 breast cancer patients whose first metastases were found in the lungs was investigated. 18 months after the start of primary treatment 50% of the patients had developed pulmonary metastases (range: 0–81 months). In 23% of patients a solitary, and in 68% more than one, lung metastases were detected. After a median time of 4 months, in 56% of patients the disease had spread to further organs with bone (25%) and liver (17%) being the most frequent sites. First line management of lung metastases employed surgery, endocrine treatment, chemotherapy or a combination of these modalities. In 24% of patients a complete response was achieved, and in 11% a partial response, with an overall response rate of 35%. Median survival from detection of lung metastases was 13 months (range 4–123+). Patients with only a solitary lung metastasis survived for a median of 11.5 months as compared to 10.5 months for patients with more than one pulmonary metastases. Patients with a disease-free interval of more than 18 months survived significantly longer than patients with a disease-free survival of 18 months or less.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726581
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  • 2
    Electronic Resource
    Electronic Resource
    Mucin-like cancer-associated antigen (MCA) compared with CA 15-3 in advanced breast cancer (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 813-817 
    Details
    ISSN: 1432-1440
    Keywords: Tumor marker ; MCA ; CA 15-3 ; Breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mucin-like cancer-associated antigen (MCA), a new tumor marker using the mouse monoclonal antibody b-12 is thought to be of value in the management of patients with breast cancer. In this study sera from 191 female patients with breast cancer (112 with progressive disease [PD] and 79 with no evidence of disease [NED]) were analyzed for MCA levels and compared with those of cancer antigen 15-3 (CA 15-3) in single determination and in combination with carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA). A cut-off level of 14 U/ml for MCA seems to be more appropriate than the recommended 11 U/ml to distinguish between PD and NED in patients with breast cancer. Although there was a fairly good correlation of MCA to CA 15-3, MCA was inferior in sensitivity and specificity to CA 15-3. Patients with osseous metastases and those with more than one metastatic site showed higher MCA levels than patients with visceral or soft tissue metastases, a fact which was comparable to CA 15-3. Combining MCA and CA 15-3 resulted in a gain in specificity but marked loss of sensitivity. The combination of MCA and CEA results also in a loss of sensitivity whereas the combination of CA 15-3 and CEA showed an increased specificity and only a negligible loss of sensitivity. The combination of MCA with TPA is of little value in the follow-up of breast cancer, as is the combination of CA 15-3 with TPA. The combination of CA 15-3 with CEA can be still recommended for follow-up for early detection of metastases in breast cancer. Further investigations with MCA to determine the lead time of this new marker as well as its role as a possible monitor of the response to therapy are recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01725197
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  • 3
    Electronic Resource
    Electronic Resource
    Acute cardiac toxicity in patients after doxorubicin treatment and the effect of combined tocopherol and nifedipine pretreatment (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 143-147 
    Details
    ISSN: 1432-1335
    Keywords: Doxorubicin ; Acute cardiac toxicity ; Prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In two groups of female patients with metastatic breast cancer who had all been pretreated with doxorubicin (350 mg/m2), acute cardiac effects following i.v. doxorubicin bolus injection (60 mg/m2) were recorded on the basis of systolic time intervals (STI). In six patients who received doxorubicin only the ratio between the heart-beat-corrected preejection period and left ventricular ejection time (PEPI:LVETI) as well as the PEP index were found to be significantly increased with a peak at 6 h following drug infusion (P〈0.001). Another six patients received an identical chemotherapeutic regimen and, in addition, a combination of tocopherol (200 mg i.m. 6 h before treatment) and nifedipine (60 mg p.o. daily from 2 days before doxorubicin infusion). In the pretreatment group, the PEPI: LVETI ration and PEP index remained unchanged during the posttreatment period. Pharmacokinetic analysis of drug concentrations in the plasma revealed a significantly accelerated distribution and elimination of doxorubicin after combined tocopherol and nifedipine pretreatment, although no statistically significant differences could be found in calculated drug levels in the peripheral compartment between both treatment groups. Our results indicate that acute cardiac reactions reflected by changes in STI values can be prevented by combined tocopherol and nifedipine pretreatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395393
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  • 4
    Electronic Resource
    Electronic Resource
    Reverse Transcriptase im menschlichen Blutplasma (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 1060-1062 
    Details
    ISSN: 1432-1440
    Keywords: Breast cancer ; leukemia ; reverse transcriptase ; tumor viruses ; Leukämie ; Mammacarcinom ; reverse Transcriptase ; Tumorviren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Arbeitsgruppen um Spiegelman und unserer Laboratorien haben nachgewiesen, daß das Enzym reverse Transcriptase auch extrazellulär bei malignen Erkrankungen aufgefunden werden kann. Ein solches Enzym wurde von Spiegelman aus der Muttermilch, von uns aus dem Plasma von Patientinnen mit Mammacarcinom und leukämischen Erkrankungen isoliert. Das von uns isolierte Enzym wurde zur elektrophoretischen Homogenität angereichert und kann 1) synthetische Templates (Primers) mit der der viralen Transcriptase inhärenten Spezifität ablesen; 2) heteropolymere RNA-Anteile einer einsträngigen Phagen-RNA in eine homologe DNA-Sequenz übersetzen und 3) weist chromatographisch ähnliches Verhalten wie die reverse Transcriptase onkogener RNA-Tumorviren auf. Vorläufige Untersuchungen zum Nachweis eines analogen Enzyms im Plasma bei anderen malignen Erkrankungen haben bisher kein positives Ergebnis gebracht.
    Notes: Summary Work from Spiegelman and from our laboratories documented extracellular occurrence of the enzyme reverse transcriptase in malignant states. This enzyme was shown to be present in particles of human milk by Spiegelman and in patients with breast cancer or leukemias by us. The isolated enzyme was purified to electrophoretic homogenity and 1) Utilizes synthetic template—primers with a specificity like the viral reverse transcriptase. 2) Is capable of copying heteropolymeric regions of natural RNA-template-primer complexes. 3) Shows the chromatographic behaviour of the viral enzyme. These preliminary investigations documented the presence of the above mentioned enzyme only in these two forms of malignancies, while the other patients looked treated for the probably viralrelated enzyme in the plasma were negative.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468992
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  • 5
    Electronic Resource
    Electronic Resource
    Reverse Transcriptaseaktivitäten im Plasma einer Patientin mit Mammacarcinom (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 1076-1078 
    Details
    ISSN: 1432-1440
    Keywords: Breast cancer ; Reverse transcriptase ; RNA-dependent DNA polymerase ; Mammacarcinom ; Reverse Transcriptase ; RNA-abhängige DNA-Polymerase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Plasma einer Patientin mit Mammacarcinom konnte ein Enzym nachgewiesen werden, welches RNA als Template für die DNA-Synthese heranziehen kann. Dieses Enzym steht in Analogie zur reversen Transcriptase onkogener RNA-Viren und dem aus der Muttermilch isolierten Enzym von Spiegelmanet al. Die mögliche diagnostische Anwendbarkeit dieses Befundes wird diskutiert.
    Notes: Summary In the plasma of a patient with breast cancer, an enzyme was shown that might use natural RNAs as templates for the DNA synthesis. This enzyme is paralleled to the reverse transcriptase of oncogenic RNA viruses and the enzyme of Spiegelmanet al. from particles of human milk. The possible diagnostic implications of these findings are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468324
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  • 6
    Electronic Resource
    Electronic Resource
    Toxicity and response to high-dose ifosfamide+mesna as salvage therapy for advanced breast cancer (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 602-604 
    Details
    ISSN: 1432-1335
    Keywords: Ifosfamide+mesna ; Breast cancer ; Toxicity ; Salvage therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-six cycles of high-dose ifosfamide+mesna (HD-IFO+M) were applied to seven female patients with advanced breast cancer refractory to prior treatment, using three different durations of continuous infusion (4, 24, and 48 h) every 3 weeks. To evaluate the most tolerable time schedule, the duration of the infusions was changed periodically in each patient. Toxicity was low in general, but continuous infusion of HD-IFO+M over 24 h appeared to be the best tolerated. On partial response lasting 27 weeks was achieved and four patients achieved stable disease lasting from 9 to 12 weeks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00398184
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  • 7
    Electronic Resource
    Electronic Resource
    272. Ergebnisse einer prospektiv randomisierten Studie beim operablen Mammacarcinom (1983)
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 776-776 
    Details
    ISSN: 1435-2451
    Keywords: Breast cancer ; Prospective randomized trial ; Mammacarcinom ; Prospektiv randomisierte Studie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im multifaktoriellen Versuchsansatz wurden operatives Vorgehen, Resektion (R) versus modifiziert radikale Mastektomie (M) und M versus klassisch radikaler Mastektomie (RM), und Fragen der adjuvanten Therapie, Chemo- und Chemoimmunotherapie gegenüber einer Kontrollgruppe, an 241 Patientinnen nach dem rezidivfreien Überleben — 30 Monate mediane Beobachtungszeit — beurteilt. R schnitt gegenüber M signifikant schlechter ab. Dagegen zeigte M gleich gute Ergebnisse wie RM. Fälle mit Chemotherapie waren gegenüber der Kontrollgruppe signifikant besser dran. Keine Verbesserung brachte die Immunotherapie mit Azimexon.
    Notes: Summary Surgical treatment, partial resection (R) versus modified radical mastectomy (M) and M versus the classical Halsted procedure (RM) as well as adjuvant treatment forms, chemotherapy and chemoimmunotherapy versus an untreated control group were all evaluated in 241 patients, with a median observation time of 30 months. Whereas M showed significantly better results than R, no difference could be observed when comparing M and RM. The disease-free interval was significantly reduced in the control group as compared to patients receiving chemotherapy. No benefit could be detected in patients with immunotherapy (azimexon).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276097
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  • 8
    Electronic Resource
    Electronic Resource
    231. Vier-Jahresergebnisse einer prospektiv randomisierten Studie beim operablen Mammacarcinom (1985)
    Springer
    Langenbeck's archives of surgery 366 (1985), S. 654-654 
    Details
    ISSN: 1435-2451
    Keywords: Breast cancer ; Prospective randomized trial ; Mammacarcinom ; Randomisierte Studie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Operatives Vorgehen, Resektion (R) versus modifiziert radikale Mastektomie (M) und M versus klassisch radikaler Mastektomie (RM) und Fragen der adjuvanten Therapie, Chemound Chemoimmunotherape gegenüber einer Kontrollgruppe wurden 241 Patientinnen nach rezidivfreiem und absolutem Überleben beurteilt. Die mediane Beobachtungszeit beträgt 48 Monate. R schnitt gegenuber M in beiden Parametern signifikant schlechter ab. Dagegen fand sich kein Unterschied zwischen M and RM. Im Gegensatz zur Auswertung nach 30 min konnte kein signifikanter Unterschied bei den adjuvant behandelten Patientinnen nach 48 Monaten gefunden werden. Patientinnen mit receptor-negativen, Grad III Tumoren überlebten mit Chemotherapie signifikant besser.
    Notes: Summary In 241 patients, with a median observation time of 48 months, surgical treatment, partial resection (R) versus modified radical mastectomy (M) and M versus Halsted's procedure (RM), as well as adjuvant treatment forms, chemotherapy and chemoimmunotherapy versus an untreated control group were all evaluated. Whereas M showed significantly better results (RFS, absolute survival) than R, no difference could be observed when comparing M and RM. At 48 months no significant differences could be detected for patients with adjuvant chemotherapy, but patients bearing receptornegative, grade III tumors did significantly better when receiving chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01836830
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  • 9
    Electronic Resource
    Electronic Resource
    Die Synthese von 1-Amino-4-aryl-1,2,3-triazolen aus α-Brom-und α,α-Dibromcarbonylverbindungen (1971)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 313 (1971), S. 882-888 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Sowohl durch Umsetzung von α-Brommethyl- als auch von α,α-Dibrommethyl-aryl-ketonen mit Hydrazin lassen sich 1-Amino-4-aryl-1,2,3-triazole darstellen, deren reduktive Desaminierung 1-H-4-Aryl-1,2,3-triazole liefert.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19713130513
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  • 10
    Electronic Resource
    Electronic Resource
    Über die Bildung von Silbereisenoxid aus Eisenhydroxid und Silberoxid in alkalischer Lösung (1960)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 304 (1960), S. 181-184 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: All modifications of iron(III) hydroxide are transformed into silver-iron(III) oxide, AgFeO2, by reaction with freshly precipitated silver oxide in hot sodium hydroxide solutions. The transformations having different velocities for the indicidual iron(III) hydroxide species occur in the liquid phase.The Structure of AgFeO2 is similar to that of α-NaFeO2.
    Notes: Alle Modifikationen von Eisen(III)-hydroxid werden nach der Vorschrift von Krause, d. h. durch Erwärmen mit gefälltem Silberoxid in Natronlauge, in Silbereisenoxid AgFeO2 umgewandelt, wenn auch sehr verschieden rasch. Die Umsetzung erfolgt über die Lösung. AgFeO2 besitzt eine ähnliche Struktur wie α-NaFeO2.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19603040308
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