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  • Mammacarcinom  (4)
  • Leukämie  (2)
  • Acute cardiac toxicity  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Acute cardiac toxicity in patients after doxorubicin treatment and the effect of combined tocopherol and nifedipine pretreatment (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 143-147 
    Details
    ISSN: 1432-1335
    Keywords: Doxorubicin ; Acute cardiac toxicity ; Prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In two groups of female patients with metastatic breast cancer who had all been pretreated with doxorubicin (350 mg/m2), acute cardiac effects following i.v. doxorubicin bolus injection (60 mg/m2) were recorded on the basis of systolic time intervals (STI). In six patients who received doxorubicin only the ratio between the heart-beat-corrected preejection period and left ventricular ejection time (PEPI:LVETI) as well as the PEP index were found to be significantly increased with a peak at 6 h following drug infusion (P〈0.001). Another six patients received an identical chemotherapeutic regimen and, in addition, a combination of tocopherol (200 mg i.m. 6 h before treatment) and nifedipine (60 mg p.o. daily from 2 days before doxorubicin infusion). In the pretreatment group, the PEPI: LVETI ration and PEP index remained unchanged during the posttreatment period. Pharmacokinetic analysis of drug concentrations in the plasma revealed a significantly accelerated distribution and elimination of doxorubicin after combined tocopherol and nifedipine pretreatment, although no statistically significant differences could be found in calculated drug levels in the peripheral compartment between both treatment groups. Our results indicate that acute cardiac reactions reflected by changes in STI values can be prevented by combined tocopherol and nifedipine pretreatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395393
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Reverse Transcriptase im menschlichen Blutplasma (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 1060-1062 
    Details
    ISSN: 1432-1440
    Keywords: Breast cancer ; leukemia ; reverse transcriptase ; tumor viruses ; Leukämie ; Mammacarcinom ; reverse Transcriptase ; Tumorviren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Arbeitsgruppen um Spiegelman und unserer Laboratorien haben nachgewiesen, daß das Enzym reverse Transcriptase auch extrazellulär bei malignen Erkrankungen aufgefunden werden kann. Ein solches Enzym wurde von Spiegelman aus der Muttermilch, von uns aus dem Plasma von Patientinnen mit Mammacarcinom und leukämischen Erkrankungen isoliert. Das von uns isolierte Enzym wurde zur elektrophoretischen Homogenität angereichert und kann 1) synthetische Templates (Primers) mit der der viralen Transcriptase inhärenten Spezifität ablesen; 2) heteropolymere RNA-Anteile einer einsträngigen Phagen-RNA in eine homologe DNA-Sequenz übersetzen und 3) weist chromatographisch ähnliches Verhalten wie die reverse Transcriptase onkogener RNA-Tumorviren auf. Vorläufige Untersuchungen zum Nachweis eines analogen Enzyms im Plasma bei anderen malignen Erkrankungen haben bisher kein positives Ergebnis gebracht.
    Notes: Summary Work from Spiegelman and from our laboratories documented extracellular occurrence of the enzyme reverse transcriptase in malignant states. This enzyme was shown to be present in particles of human milk by Spiegelman and in patients with breast cancer or leukemias by us. The isolated enzyme was purified to electrophoretic homogenity and 1) Utilizes synthetic template—primers with a specificity like the viral reverse transcriptase. 2) Is capable of copying heteropolymeric regions of natural RNA-template-primer complexes. 3) Shows the chromatographic behaviour of the viral enzyme. These preliminary investigations documented the presence of the above mentioned enzyme only in these two forms of malignancies, while the other patients looked treated for the probably viralrelated enzyme in the plasma were negative.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468992
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  • 3
    Electronic Resource
    Electronic Resource
    Reverse Transcriptaseaktivitäten im Plasma einer Patientin mit Mammacarcinom (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 1076-1078 
    Details
    ISSN: 1432-1440
    Keywords: Breast cancer ; Reverse transcriptase ; RNA-dependent DNA polymerase ; Mammacarcinom ; Reverse Transcriptase ; RNA-abhängige DNA-Polymerase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Plasma einer Patientin mit Mammacarcinom konnte ein Enzym nachgewiesen werden, welches RNA als Template für die DNA-Synthese heranziehen kann. Dieses Enzym steht in Analogie zur reversen Transcriptase onkogener RNA-Viren und dem aus der Muttermilch isolierten Enzym von Spiegelmanet al. Die mögliche diagnostische Anwendbarkeit dieses Befundes wird diskutiert.
    Notes: Summary In the plasma of a patient with breast cancer, an enzyme was shown that might use natural RNAs as templates for the DNA synthesis. This enzyme is paralleled to the reverse transcriptase of oncogenic RNA viruses and the enzyme of Spiegelmanet al. from particles of human milk. The possible diagnostic implications of these findings are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468324
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  • 4
    Electronic Resource
    Electronic Resource
    Steigerung der Aufnahme Aminoacylierter Transferribonucleinsäuren menschlicher Leukocyten nach Genaktivierung durch Phytohæmagglutinin und bei Leukämie (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 138-142 
    Details
    ISSN: 1432-1440
    Keywords: Gene activation ; leukemia ; phytohaemagglutinin ; transfer ribonucleic acids ; cell permeation ; Genaktivierung ; Leukämie ; Phytohaemagglutinin ; Transfernucleinsäuren ; Zellpermeation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die in dieser Arbeit vorgelegten Ergebnisse liefern Hinweise, die für den Transport von Transfernucleinsäuren durch die Zellmembran in das Zellinnere und für das Vorliegen dieser Verbindungen in undegradierter Form intracellulär sprechen. Diese Aufnahme ist offensichtlich vom Reife- und Differenzierungsgrad von Leukocyten abhängig, da leukämische Zellen oder Blasten höhere Inkorporationsraten aufwiesen, als reife Zellen. Die Ergebnisse werden im Zusammenhang mit der Möglichkeit diskutiert, informationstragende Makromoleküle in funktionell intakte Zellen einzubringen.
    Notes: Summary The results presented in this paper provide evidence in favour of the partially undegraded transport of transfer ribonucleic acids through cell membranes of human leukocytes and of the intracellular integrity of these compounds. The magnitude of the uptake seems to depend on the grade of differentiation of blood cells; in as much as blast cells and leukemic cells appear to take up greater quantities. These results are discussed with respect to the possibility of introducing intact genetic material into living cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01620752
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  • 5
    Electronic Resource
    Electronic Resource
    272. Ergebnisse einer prospektiv randomisierten Studie beim operablen Mammacarcinom (1983)
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 776-776 
    Details
    ISSN: 1435-2451
    Keywords: Breast cancer ; Prospective randomized trial ; Mammacarcinom ; Prospektiv randomisierte Studie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im multifaktoriellen Versuchsansatz wurden operatives Vorgehen, Resektion (R) versus modifiziert radikale Mastektomie (M) und M versus klassisch radikaler Mastektomie (RM), und Fragen der adjuvanten Therapie, Chemo- und Chemoimmunotherapie gegenüber einer Kontrollgruppe, an 241 Patientinnen nach dem rezidivfreien Überleben — 30 Monate mediane Beobachtungszeit — beurteilt. R schnitt gegenüber M signifikant schlechter ab. Dagegen zeigte M gleich gute Ergebnisse wie RM. Fälle mit Chemotherapie waren gegenüber der Kontrollgruppe signifikant besser dran. Keine Verbesserung brachte die Immunotherapie mit Azimexon.
    Notes: Summary Surgical treatment, partial resection (R) versus modified radical mastectomy (M) and M versus the classical Halsted procedure (RM) as well as adjuvant treatment forms, chemotherapy and chemoimmunotherapy versus an untreated control group were all evaluated in 241 patients, with a median observation time of 30 months. Whereas M showed significantly better results than R, no difference could be observed when comparing M and RM. The disease-free interval was significantly reduced in the control group as compared to patients receiving chemotherapy. No benefit could be detected in patients with immunotherapy (azimexon).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276097
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  • 6
    Electronic Resource
    Electronic Resource
    231. Vier-Jahresergebnisse einer prospektiv randomisierten Studie beim operablen Mammacarcinom (1985)
    Springer
    Langenbeck's archives of surgery 366 (1985), S. 654-654 
    Details
    ISSN: 1435-2451
    Keywords: Breast cancer ; Prospective randomized trial ; Mammacarcinom ; Randomisierte Studie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Operatives Vorgehen, Resektion (R) versus modifiziert radikale Mastektomie (M) und M versus klassisch radikaler Mastektomie (RM) und Fragen der adjuvanten Therapie, Chemound Chemoimmunotherape gegenüber einer Kontrollgruppe wurden 241 Patientinnen nach rezidivfreiem und absolutem Überleben beurteilt. Die mediane Beobachtungszeit beträgt 48 Monate. R schnitt gegenuber M in beiden Parametern signifikant schlechter ab. Dagegen fand sich kein Unterschied zwischen M and RM. Im Gegensatz zur Auswertung nach 30 min konnte kein signifikanter Unterschied bei den adjuvant behandelten Patientinnen nach 48 Monaten gefunden werden. Patientinnen mit receptor-negativen, Grad III Tumoren überlebten mit Chemotherapie signifikant besser.
    Notes: Summary In 241 patients, with a median observation time of 48 months, surgical treatment, partial resection (R) versus modified radical mastectomy (M) and M versus Halsted's procedure (RM), as well as adjuvant treatment forms, chemotherapy and chemoimmunotherapy versus an untreated control group were all evaluated. Whereas M showed significantly better results (RFS, absolute survival) than R, no difference could be observed when comparing M and RM. At 48 months no significant differences could be detected for patients with adjuvant chemotherapy, but patients bearing receptornegative, grade III tumors did significantly better when receiving chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01836830
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