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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 54 (1999), S. 843-845 
    ISSN: 1432-1041
    Keywords: Key words Piritramide ; Protein binding ; Acute phase response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: Piritramide is a lipophilic opioid, which is widely used for postoperative analgesia and analgosedation in Europe. In this study we investigated the influence of various protein concentrations (total protein, 1-acid glycoprotein, albumin) and the postoperative acute phase response on the protein binding of piritramide. Methods: The influence of various protein concentrations on the protein binding of piritramide was investigated by either diluting the serum samples of five volunteers with isotonic saline or by adding different amounts of 1-acid glycoprotein. Albumin binding was measured in a 5% human albumin solution. The impact of the postoperative acute phase response was investigated by obtaining daily serum samples from 18 surgical patients until the third postoperative day, and measuring piritramide protein binding, 1-acid glycoprotein, total protein and albumin. Results: There was a significant relationship between piritramide protein binding and the concentrations of total protein and 1-acid glycoprotein. The binding to albumin was 88%. During the postoperative acute phase response, the protein binding of piritramide did not change. Serum concentrations of 1-acid glycoprotein increased, whereas total protein and albumin decreased. Conclusion: Although there were significant changes in the piritramide-binding proteins, 1-acid glycoprotein and albumin, during the postoperative acute phase response, the protein binding of piritramide did not change. Therefore, a change in protein binding, which might be one factor to be considered in determining piritramide dosage in the postoperative period, does not have to be taken into account.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-2451
    Keywords: Key words Head and neck neoplasms ; Enteral resection ; Jejunal autotransplantation ; Reconstruction of the oropharyngeal cavity ; Schlüsselwörter Mundhöhlenkarzinom ; Dünndarmresektion ; Jejunum Autotransplantation ; Rekonstruktion der Mundhöhle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Rekonstruktion im Mundhöhlen-, Pharynx- und im kranialen Ösophagusbereich nach ausgedehnten, radikalen Tumorresektionen stellt eine interdisziplinäre Herausforderung dar. Eine vielfach favorisierte Technik ist die rekonstruktive Jejunumautotransplantation, bei welcher der Abdominalchirurg mit der Gewinnung des Autotransplantats beauftragt ist. Die Notwendigkeit des zusätzlichen Abdominaleingriffs macht die vorgestellte Analyse der perioperativen Komplikationen bei der Jejunumentnahme notwendig. Zusätzlich wurden 35 von 66 noch lebenden Patienten mit einem Nachuntersuchungsintervall von durchschnittlich 21 (2–63) Monaten bezüglich abdominaler Spätkomplikationen evaluiert. Bei 90 wegen eines Malignoms der Mundhöhle oder des Oropharynx operierten Patienten war die perioperative Letalität 7,8% (7/90), in keinem Fall auf Basis einer entnahmeassoziierten abdominalen Komplikation. Eine abdominale Revision erfolgte wegen subkutaner Bauchdeckendehiszenz. Aus nicht mit der Dünndarmentnahme in direktem Zusammenhang stehender Ursache mußten 4 Patienten relaparotomiert werden (2 noch während des Krankenhausaufenthalts, 2 Patienten nach erfolgter Entlassung). Bei 5 Patienten wurden konservativ behandelbare minimale Komplikationen festgestellt. Die Nachuntersuchung zeigte außer in 6 Fällen mit kleinen Narbenhernien keine Spätkomplikationen auf. Insgesamt ist festzuhalten, daß trotz des zumeist erhöhten perioperativen Risikos dieses Patientenguts die Komplikationsrate des zusätzlichen Abdominaleingriffs zur Gewinnung des optimalen Rekonstruktionsgewebes gering und vertretbar erscheint.
    Notes: Abstract Reconstruction after radical tumor resection in the oropharyngeal region still represents an interdisciplinary challenge. Autotransplantation of the jejunum is a popular procedure, in which the abdominal surgeon's main task is that of harvesting enteral tissue. To evaluate this technique, a careful analysis of accompanying perioperative abdominal complications was performed. Additionally, we reexamined 35 of 66 patients still living after a follow-up period of 21 (range 2–63) months on average. The perioperative mortality of 90 patients treated for oropharyngeal malignancy using the described procedure was 7.8%. None of the perioperative deaths was caused by an abdominal complication associated with enteral resection. One abdominal reoperation was performed because of abdominal wall dehiscence. For reasons not related to enteral resection, four further patients had to be relaparotomized, two of them during their hospital stay and two after leaving hospital. In five cases we observed minor complications which could be treated nonsurgically. In the follow-up reexamination we detected no abdominal late-onset complication except small incisional hernias in six cases. Finally, we concluded that despite an elevated overall operative risk in this population, complications owing to jejunal resection were comparably low. The data regarding the rate of complications classify jejunal resection as a safe procedure for reconstructive purposes in patients suffering from oropharyngeal malignancy.
    Type of Medium: Electronic Resource
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