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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 93 (1988), S. 50-54 
    ISSN: 0942-0940
    Keywords: Optic nerve lesion ; operative treatment ; conservative treatment ; head injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The problems of therapy are described by comparing a retrospective (17 cases) to a prospective (12 cases) study of cases of traumatic lesions of the optic nerve. Intensive cooperation between specialists and a quick diagnosis facilitate the decision regarding treatment and lead to better results. Indication for surgical treatment — transcranial or transethmoidal approach — should be confined to posttraumatic deterioration of optic nerve function in combination with fractures of the optic canal, and to its deterioration in spite of proper conservative treatment — shock treatment and cortisone infusions-.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 10 (1988), S. 101-106 
    ISSN: 1279-8517
    Keywords: Sonography ; Mimetic musculature ; Anatomic clinical study ; Facial palsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Des études anatomiques antérieures nous ont permis d'identifier et de différencier chacun des muscles de la mimique. Secondairement, nous avons analysé les possibilités offertes par les ultrasons pour visualiser la musculature faciale chez 15 volontaires. Cette méthode a également été utilisée dans le bilan diagnostic de certains états pathologiques, notamment les paralysies faciales. Les excellents renseignements obtenus sur la musculature faciale montrent que cette technique peut être utile à la fois au diagnostic précis de la paralysie faciale et à la décision thérapeutique plastique ou reconstructive ainsi qu'à la surveillance à distance.
    Notes: Summary Primary anatomic studies served for identification and differentiation of the individual mimetic muscles. As a second step, we investigated the clinical potential of ultrasound imaging to visualize the mimetic musculature in 15 volunteers. This examination technique was used to diagnose pathological alterations, especially associated with facial palsy. The excellent sonographic visualization of the mimetic musculature indicates that this technique may be a valuable adjunct in the diagnosis and differentiation of facial palsy, as well as in planning plastic surgery and reconstructive procedures, and in follow-up care.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 10 (1988), S. 3-4 
    ISSN: 1279-8517
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1435-0130
    Keywords: Key words Jejunal autotransplantation ; Head and neck carcinoma ; Complications ; Surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The study was performed to evaluate abdominal complications related to jejunal segment resection for reconstruction after radical oropharyngeal tumor resection. Perioperative complications of 104 patients (median age, 53.7 years; 23 female; 81 male) who underwent surgery for oropharyngeal malignancy after radiochemotherapy and the long-term morbidity of 35 patients after a median follow-up period of 21 months are analyzed. The perioperative mortality was 8.7% (9/104); none of the perioperative deaths was caused by an abdominal complication associated with the jejunal resection. In three cases, repeat laparotomy was performed within 30 days of jejunal autotransplantation: in two of them the reason was not directly associated with bowel resection and one patient had an abdominal wall dehiscence. In six cases there were minor abdominal complications which could be treated nonsurgically. There was no anastomotic leakage, bowel obstruction or postoperative bleeding. In the follow-up re-examination, no late onset abdominal complications were noted except small incisional hernias in six of the 35 patients; only one required a hernia repair. Despite a potentially increased operative risk in these patients, the complication rate after bowel resection for jejunal autotransplantation was low. This is a safe procedure in patients with oropharyngeal carcinoma.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of plastic surgery 21 (1998), S. 166-170 
    ISSN: 1435-0130
    Keywords: Key words Mucosa ; Prelamination ; Axial pattern flaps ; Head and neck reconstruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Until now the microvascular fasciocutaneous radial forearm flap has been one of several methods favoured for reconstruction of intraoral soft tissue defects after radical resection of squamous cell carcinoma. Mucosal reconstruction and lining has been performed by a skin island, this is epidermis and cannot produce mucus. In order to provide mucosal properties and allow mucus production, a distal radial forarm flap has been successfully prelaminated with buccal mucosa in five patients. By this method thin, pliable and resistant flaps have been produced. Due to mucosal spreading, the mucosa lined area was 30–50% larger than the originally inserted mucosal grafts. Preservation of skin and subcutaneous tisssue lowered donor site morbidity. This technique has also been performed in axial pattern flaps; two osteofasciomucosal fibulae and three myomucosal pectoralis major flaps.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1435-0130
    Keywords: Key words Mucosal prelamination ; Radial forearm flap ; Donor site morbidity ; Head and neck reconstruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In order to reconstruct intraoral lining defects after radical tumor resection, mucosal prelamination of the fascia of the distal radial forearm flap was performed in ten patients. By this method a physiologic reconstruction with mucus-producing tissue could be achieved. Preservation of skin and subcutaneous tissue enabled primary closure of the donor site. The exposed median nerve and flexor tendons could be covered by well-vascularized tissue with, hopefully, less donor site morbidity. To investigate this, eight prelamination patients were compared to five patients in whom conventional fasciocutaneous distal radial forearm flaps were harvested. Follow-up was 6–25 months (mean 12.8 months). All patients with prelaminated forearm flaps revealed excellent functional and cosmetic results. Restricted hand function and a poor cosmetic result were found in 40% of the fasciocutaneous flap patients. Subjective cold intolerance could be objectified using thermography, but could not be confirmed, using rheography and photoplethysmography.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1434-4726
    Keywords: Key words Oral mucosa ; Keratinocyte isolation ; Immunomagnetic beads ; Cytokine assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In studying human oral keratinocytes, it would be very helpful to obtain a pure population of cells without prior in vitro expansion. An immunomagnetic separation technique, or magnetic cell separation (MACS), was modified for efficient purification of human oral keratinocytes. Subsequent to two-step enzymatic digestion, the cell suspension was labelled with a mouse anti-CD45 (pan-leukocyte) monoclonal antibody (MoAb) to stain mononuclear cells. In a second step a rat anti-mouse antibody conjugated with colloidal superparamagnetic particles was used. Labelled cells were retained in the magnetic field of a permanent magnet on columns containing a ferromagnetic matrix. The unlabelled, unretained cells were further examined by flow cytometry analysis, enzyme-linked immunosorbent assay and polymerase chain reaction. After the MACS procedure, unretained cells showed a strong positivity for the lu-5 MoAb (as a marker for pan-cytokeratin) and were negative for anti-vimentin (to mark mesenchymal cells), for anti-CD45 MoAb and for melanocyte-detecting antibodies, thus representing pure keratinocytes (〉 98%). Purified keratinocytes maintained full viability (〉 91%) and functional capacities. [3H]thymidine uptake and epidermal growth factor (EGF) receptor expression were unaltered when compared with the non-separated cell population. Furthermore, interleukin-1α was detected at the protein and RNA levels in keratinocytes immediately after MACS enrichment. Our findings show that MACS appears to be a useful tool for purification of oral keratinocytes and allows for further functional studies without prior subcultivation of cells.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2102
    Keywords: Schlüsselwörter MRT ; CT ; Jejunum transplantat ; Plattenepithelkarzinome ; Key words MRI ; CT ; Jejunal patch ; Squamouse cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Freely transplanted, microvascularly anastomosed jejunal patches can be used to cover soft tissue defects in the oral cavity or oropharynx after the resection of malignant tumors. Even a patch without complications or alteration from tumor recurrence is morphologically diverse. Therefore it is difficult to distinguish between malignant and benign alterations, and knowledge of the possible morphological spectrum and the significance of an alteration is of practical interest. Computed tomography (CT; n = 30) and magnetic resonance imaging (MRI; n = 13) were used for follow-up examinations in patients who had an operative reconstruction with a jejunal patch. Three parts of a patch were differentiated with both imaging modalities: the region of the anastomosis, the mesenterial fatty tissue and the intestinal wall. The morphology of the patches correlated with clinical findings in the following cases. The patches were identified satisfactorily by CT and MRI. The appearance of patches without complications was influenced by a variable degree of fibrosis and by persistent intestinal folds. Recurrent tumors only infiltrated the margins of the patches. Destructive alterations in the patches were always less severe than those in the original orofacial soft tissue. Postoperative follow-up examinations with CT and MRI are particularly important when tumor recurrences spread under a patch, since these tumors are invisible in the clinical examinations. CT was advantageous in demonstrating osseous alterations and showed less loss of image quality in patients for whom the implantation of multiple metallic hardware during the operation had been necessary.
    Notes: Zusammenfassung Zur Deckung von Weichteildefekten nach Tumorresektionen im Bereich der Mundhöhle und im Oropharynx können freie Transplantate verwendet werden. Eine häufig angewandte Technik ist der Einsatz frei transplantierter, mikrovaskulär anastomosierter Dünndarmlappen. Bereits das komplikationslose Transplantat weist eine erhebliche morphologische Vielfalt auf. Eine Abgrenzung gutartiger von bösartigen Veränderungen kann deshalb schwierig sein, weshalb die Kenntnis des Spektrums an morphologischen Alterationen von praktischem Interesse ist. Mittels Computertomographie (CT) (n = 30) und Magnetresonanztomographie (MRT) (n = 13) wurden im Rahmen der postoperativen Tumornachsorge Patienten mit Dünndarminterponaten untersucht. An den Interponaten wurden folgende Anteile unterschieden: die Anastomosenregion, das Mesenterium und die Darmwand. Die Morphologie dieser Anteile wurde mit dem klinischen Befund korreliert. Die Ergebnisse zeigen eine zufriedenstellende Abgrenzbarkeit der einzelnen Anteile der Transplantate mit beiden tomographischen Methoden. Die morphologische Heterogenität der als komplikationslos eingestuften Transplantate zeigte sich v. a. in einer unterschiedlichen Ausprägung postoperativer Veränderungen, wie Fibrosierung oder der Persistenz des intestinalen Faltenreliefs. Lokale Tumorrezidive infiltrieren die Interponate hauptsächlich in den Randpartien und destruieren das intestinale Gewebe in weit geringerem Ausmaß als die ortseigenen oralen oder pharyngealen Weichteile. Die Wichtigkeit der radiologischen Untersuchung wird durch Rezidivtumore, welche unterhalb des Dünndarminterponats wachsen und dadurch dem klinischen Nachweis entgehen können, unterstrichen. In der Tumornachsorge können sowohl die MRT als auch die CT eingesetzt werden, wobei aufgrund der besseren Nachweisbarkeit ossärer Läsionen sowie der geringeren Artefaktauswirkung metallischer Implantate der CT derzeit eher der Vorzug zu geben ist.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1435-2451
    Keywords: Key words Head and neck neoplasms ; Enteral resection ; Jejunal autotransplantation ; Reconstruction of the oropharyngeal cavity ; Schlüsselwörter Mundhöhlenkarzinom ; Dünndarmresektion ; Jejunum Autotransplantation ; Rekonstruktion der Mundhöhle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Rekonstruktion im Mundhöhlen-, Pharynx- und im kranialen Ösophagusbereich nach ausgedehnten, radikalen Tumorresektionen stellt eine interdisziplinäre Herausforderung dar. Eine vielfach favorisierte Technik ist die rekonstruktive Jejunumautotransplantation, bei welcher der Abdominalchirurg mit der Gewinnung des Autotransplantats beauftragt ist. Die Notwendigkeit des zusätzlichen Abdominaleingriffs macht die vorgestellte Analyse der perioperativen Komplikationen bei der Jejunumentnahme notwendig. Zusätzlich wurden 35 von 66 noch lebenden Patienten mit einem Nachuntersuchungsintervall von durchschnittlich 21 (2–63) Monaten bezüglich abdominaler Spätkomplikationen evaluiert. Bei 90 wegen eines Malignoms der Mundhöhle oder des Oropharynx operierten Patienten war die perioperative Letalität 7,8% (7/90), in keinem Fall auf Basis einer entnahmeassoziierten abdominalen Komplikation. Eine abdominale Revision erfolgte wegen subkutaner Bauchdeckendehiszenz. Aus nicht mit der Dünndarmentnahme in direktem Zusammenhang stehender Ursache mußten 4 Patienten relaparotomiert werden (2 noch während des Krankenhausaufenthalts, 2 Patienten nach erfolgter Entlassung). Bei 5 Patienten wurden konservativ behandelbare minimale Komplikationen festgestellt. Die Nachuntersuchung zeigte außer in 6 Fällen mit kleinen Narbenhernien keine Spätkomplikationen auf. Insgesamt ist festzuhalten, daß trotz des zumeist erhöhten perioperativen Risikos dieses Patientenguts die Komplikationsrate des zusätzlichen Abdominaleingriffs zur Gewinnung des optimalen Rekonstruktionsgewebes gering und vertretbar erscheint.
    Notes: Abstract Reconstruction after radical tumor resection in the oropharyngeal region still represents an interdisciplinary challenge. Autotransplantation of the jejunum is a popular procedure, in which the abdominal surgeon's main task is that of harvesting enteral tissue. To evaluate this technique, a careful analysis of accompanying perioperative abdominal complications was performed. Additionally, we reexamined 35 of 66 patients still living after a follow-up period of 21 (range 2–63) months on average. The perioperative mortality of 90 patients treated for oropharyngeal malignancy using the described procedure was 7.8%. None of the perioperative deaths was caused by an abdominal complication associated with enteral resection. One abdominal reoperation was performed because of abdominal wall dehiscence. For reasons not related to enteral resection, four further patients had to be relaparotomized, two of them during their hospital stay and two after leaving hospital. In five cases we observed minor complications which could be treated nonsurgically. In the follow-up reexamination we detected no abdominal late-onset complication except small incisional hernias in six cases. Finally, we concluded that despite an elevated overall operative risk in this population, complications owing to jejunal resection were comparably low. The data regarding the rate of complications classify jejunal resection as a safe procedure for reconstructive purposes in patients suffering from oropharyngeal malignancy.
    Type of Medium: Electronic Resource
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