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  • treatment  (2)
  • Adenosine  (1)
  • Bromodeoxyuridine  (1)
  • Creutzfeldt-Jakob disease  (1)
  • 1
    Electronic Resource
    Electronic Resource
    A new method to classify amyloid fibril proteins (1985)
    Springer
    Acta neuropathologica 67 (1985), S. 272-278 
    Details
    ISSN: 1432-0533
    Keywords: Amyloidosis ; Amyloid fibril protein ; Creutzfeldt-Jakob disease ; Senile dementia of Alzheimer type ; Autoclaving
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The permanganate method, the immunoperoxidase method, and a newly developed autoclave method were used to distinguish different types of amyloid fibril proteins in formalin-fixed, paraffinembedded tissue sections. All tissues from permanganate-sensitive cases (AA type) lost the affinity of Congo red and green birefringence under polarized light after incubation with special autoclave treatment. AL type systemic amyloidosis and amyloid plaques of CJD and GSS were permanganate-resistant, but decreased markedly the affinity of Congo red after prolonged autoclaving. On the other hand, prealbumin type systemic amyloidosis and senile plaques of SDAT were resistant to both permanganate oxidation and prolonged autochlaving. Thus, amyloid plaques of CJD and GSS are identical to AL type in systemic amyloidosis, and senile plaques are similar to the prealbumin type. However, anti-prealbumin antiserum did not stain senile plaque amyloid. The anti-human P component stained positively systemic amuyloids and cerebral amyloid plaques of SSE, but failed to stain senile plaques of SDAT. Therefore, the amyloid fibril protein of senile plaues is apparently different from other types of amyloid depositions. Amyloid plaques of SSE are different from senile plaques not only with regard to fibril proteins, but also to globular protein in the amyloid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687812
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cell kinetics of the malignant evolution of meningothelial meningioma (1987)
    Springer
    Acta neuropathologica 74 (1987), S. 243-247 
    Details
    ISSN: 1432-0533
    Keywords: Malignant meningioma ; Local recurrence ; Cell kinetics ; Bromodeoxyuridine ; Subarachnoid dissemination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A meningotheliomatous meningioma occurred in the right parietal parasagittal region of a 43-year-old woman. A total excision was carried out. Three years and 9 months later, one parasagittal and two falx tumours in close proximity recurred and were excised. The falx tumors showed the features of an anaplastic transitional meningioma with increased mitoses. The falx meningioma recurred locally and repeatedly, despite radiation therapy and chemoimmunotherapy. She died 7 years and 8 months after the onset. At autopsy, the tumor was found to have metastasized via the cerebrospinal fluid to the spinal cord and pituitary stalk. Extracranial metastases were not evident. At the fourth craniotomy, bromodeoxyuridine (BrdU) was administered intravenously to label tumor cells in the S phase of the cell cycle. The BrdU-labeled cells accounted for 9.0%; they are usually less than 1% in benign meningiomas. Meningothelial meningiomas with a high labeling index recur rapidly, even after Simpson's grade 2 removal, and treatment for a malignant meningioma should be instituted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688188
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Selective enhancement of intratumoural blood flow in malignant gliomas: Experimental study in rats by intracarotid administration of adenosine or adenosine triphosphate (1989)
    Springer
    Acta neurochirurgica 101 (1989), S. 66-74 
    Details
    ISSN: 0942-0940
    Keywords: Adenosine ; ATP ; regional cerebral blood flow ; RG-C6 glioma ; intracarotid administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the effect of intravenous and intracarotid infusion of adenosine and adenosine triphosphate (ATP) on the regional blood flow of intracerebrally transplanted RG-C 6 tumours in rats, using the hydrogen clearance method. The intracarotid administration of adenosine or ATP selectively increased blood flow in the tumour, but did not produce any significant change either in the regional cerebral blood flow of the extratumoural ipsilateral hemisphere or in the ipsilateral hemisphere without tumour. The intracarotid administration of ATP at a dose of 10 Μg/kg/min produced the most effective increase in the tumour blood flow (+51.5± 16.8%). In contrast, both the intravenous administration of adenosine and that of ATP failed to increase tumour blood flow. These results may possibly indicate that intracarotid administration of the adenosine or ATP might contribute in selectively enhancing the delivery of anti-cancer agents to malignant brain tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410072
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  • 4
    Electronic Resource
    Electronic Resource
    Thalamic Gliomas: A clinicopathologic analysis of 20 cases with reference to patient age (1997)
    Springer
    Acta neurochirurgica 139 (1997), S. 336-342 
    Details
    ISSN: 0942-0940
    Keywords: Glioma ; thalamus ; treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty patients (M 11, F 9; ranging from 1–77 years old) with histologically proven glial tumours in the thalamic region, treated from 1979 until 1994 at Kyushu University Hospital were retrospectively reviewed and analysed in order to elucidate their clinical and neuropathological characteristics. The initial common clinical manifestations were those of increased intracranial pressure or motor weakness. The histological diagnosis of the tumour was pilocytic astrocytoma in 2 patients, fibrillary astrocytoma in 7, anaplastic astrocytoma in 7, and glioblastoma multiforme in 4. The initial treatment was surgery alone in 4 patients, surgery followed by radiation therapy in 5, surgery followed by radiation therapy and chemotherapy in 9, and conventional radiation therapy alone in 2 patients. The 3-year overall actuarial survival rate for all patients was 20% but was related to both the histological type and the age of the patients: As a result, the rate was 44% for patients with low-grade astrocytoma compared to 0% for those with high-grade astrocytoma. While 5 out of 11 patients under the age of 25 years at their initial presentation have survived for from 2–16 years after the diagnosis, all patients presenting after the age of 25 years died within 3 years after treatment. Thalamic glial tumours are not a homogeneous group of tumours in terms of clinical behaviour and histopathological features, and the poor overall results, especially in adult tumours, thus emphasise the need for continued research in the treatment of these tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01808830
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  • 5
    Electronic Resource
    Electronic Resource
    Supratentorial astrocytic tumours of childhood: A clinicopathologic study of 41 cases (1989)
    Springer
    Acta neurochirurgica 101 (1989), S. 3-8 
    Details
    ISSN: 0942-0940
    Keywords: Children ; supratentorial astrocytoma ; treatment ; prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Forty-one patients with ages from 0 to 16 years harbouring Supratentorial astrocytic tumours were treated between 1964 and 1986. Twenty-four of them were located in the cerebral hemisphere or in the ventricle, and 17 were in the basal ganglia, thalamus, and/ or optico-hypothalamic region. There were nine glioblastomas multiforme, four anaplastic astrocytomas, 11 fibrillary astrocytomas, 12 pilocytic astrocytomas, two pleomorphic xanthoastrocytomas, two subependymal giant cell astrocytomas and one primitive astrocytic tumour. Low grade tumours tended to occur in young subjects near the midline, and high grade ones in older patients in the hemisphere. Initial treatment in most the patients was a resection or biopsy followed by radiation therapy. Eleven patients were retreated for their recurrent tumours with combinations of surgical removal of the tumour, radiotherapy, and/or chemotherapy. After a follow-up of 3 months to 17 years, 51% of the patients survived with a median survival of 7 years. Outcome of the patients with Supratentorial astrocytomas correlated mostly with the histological grade of malignancy of the tumour, and to a lesser degree with the tumour location. The biological behaviour and treatment of supratentorial astrocytomas in childhood are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410061
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