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  • Magnetic resonance imaging  (2)
  • Adenosine receptors  (1)
  • Copper deficiency  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Involvement of α-adrenoceptors in the excitatory effect of the A2 adenosine receptors agonist 5′-N-ethylcarboxamidoadenosine (NECA) on cardiac automaticity in the isolated right ventricle of the rat (1994)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 350 (1994), S. 632-637 
    Details
    ISSN: 1432-1912
    Keywords: Cardiac automaticity ; Adenosine receptors ; α-adrenoceptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of the non-selective A2 adenosine receptor agonist 5′-N-ethyl-carboxamidoadenosine (NECA) were studied on ventricular automaticity induced by a local injury in the isolated right ventricle of the rat. In concentrations ranging from 0.1 to 100 nM, NECA significantly increased ventricular automaticity. This effect was not apparent when the nonselective α-adrenoceptor blocker phenoxybenzamine was present at a concentration of 10 μM, which antagonizes both α1-and α2-adrenoceptors, as well as when rats were pretreated with reserpine. In non-reserpinized rats, the excitatory effect of NECA was also abolished in the presence of the selective α1-adrenoceptor antagonist prazosin, but not in the presence of the α2-adrenoceptor antagonist idazoxan. In reserpinized rats, the excitatory effect of NECA was restored in the presence of the non specific α-adrenoceptor agonist phenylephrine as well as in the presence of the selective α1-adrenoceptor agonist amidephrine but not in the presence of the selective α2-adrenoceptor agonist clonidine. These results suggest that the excitatory effect of NECA on ectopic ventricular automaticity is dependent on endogenous catecholamines and that α-adrenoceptors of type 1 are, in some way, involved in this effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169368
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Long-term nervous system damage from radiation of the spinal cord: An electrophysiological study (1991)
    Springer
    Journal of neurology 238 (1991), S. 9-15 
    Details
    ISSN: 1432-1459
    Keywords: Radiation damage ; Spinal cord ; Magnetic resonance imaging ; Somatosensory evoked potentials ; Motor evoked potentials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A group of 13 patients suffering from Hodgkin's disease who had undergone chemotherapy and radiotherapy (above and below the diaphragm) approximately 10 years earlier was studied. The total chemotherapeutic dose was similar for all patients; the radiotherapy dose, however, was standard for 7 patients, while the other 6 received much higher dosages over limited regions of the spinal cord. Although most of these patients appeared normal both clinically and on magnetic resonance imaging, a neurophysiological study was performed to determine whether there was any involvement of the central or peripheral nervous system. Motor conduction velocity and sensory conduction velocity were measured in the lower limbs as well as spinal- and scalprecorded somatosensory evoked potentials (SEPs) in response to stimulation of the posterior tibial and sural nerves at the ankle. In addition, motor evoked potentials were recorded from the upper and lower limbs during cortical stimulation. All neurophysiological data were normal in patients who had received a standard radiation dose, while most of those who had been exposed to higher doses showed altered cortical SEPs and a slowing of central conduction time (D10-P1). Thus even though they were asymptomatic, these patients appeared to have sustained CNS damage, mainly at the level of the spinal cord.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319702
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Radiological findings in a case of Menkes' disease (1995)
    Springer
    Child's nervous system 11 (1995), S. 112-114 
    Details
    ISSN: 1433-0350
    Keywords: Menkes' disease ; Copper deficiency ; Pili torti ; Magnetic resonance imaging ; Skeletal roentgenography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Menkes' disease, a neurodegenerative progressive X-linked disorder, was diagnosed in a 4-month-old child. The diagnosis was made on the combination of clinical features with laboratory and radiological findings. The pathogenesis of the skeletal findings in Menkes' disease is as yet unclear. Because of the severity of the prognosis and in order to plan treatment, the correct diagnosis has to be reached quickly. Typical manifestations of the syndrome are likely to develop after 3 months of age, with a pleiotropic appearance. In the present case, on the basis of the clinical investigation the patient underwent retrograde cystourethrography, roentgenographic examination of the skeleton, and magnetic resonance imaging of the brain. On analysis of the magnetic resonance imaging, we detected one-sided involvement of both subcortical and cortical parenchyma resembling a unilateral ischemic lesion such as, to our knowledge, has not yet been reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303816
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    Paper (German National Licenses)
    Fulltext
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