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  • 1
    ISSN: 1432-1440
    Keywords: Adenosine Triphosphatase ; Erythrocytes ; Hypertension ; Adenosintriphosphatase ; Erythrozyten ; Hypertonie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Erhöhte intraerythrozytäre Natriumkonzentration sowie ein beschleunigter Einstrom von Na22 in die Erythrozyten von Patienten mit essentieller Hypertonie hatten zu der Vermutung geführt, daß dieser Erkrankung eine Transportstörung für Natrium an der Zellmembran zugrunde liegen könnte. Wir fanden bei 27 Patienten mit essentieller Hypertonie eine signifikante Erhöhung der durch Strophantin hemmbaren Na-K-ATP'ase an Erythrozytenghosts im Vergleich zu 32 gesunden Kontrollpersonen. Die Na-K-insensible Mg-APT'ase was dagegen bei beiden Gruppen gleich. Dieser Befund ist mit einer Aktivierung des membrangebundenen Natriumtransportes an Erythrozyten von essentiellen Hypertonikern vereinbar.
    Notes: Summary Increased sodium concentration and high influx of Na22 are reported in erythrocytes of patients with essential hypertension. It was speculated, that these findings are due to a disturbed transport for sodium across red cell membranes. We found a significantly increased activity of the ouabainsensitive Na-K-ATP'ase in red cell ghosts of 27 patients with essential hypertension compaired with 32 normotensive controls. There existed no difference in Mg-ATP'aseactivity between the two groups. These findings suggest an increased activity of the Na-pump in red cell membranes of patients with essential hypertension.
    Type of Medium: Electronic Resource
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