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  • 1
    Electronic Resource
    Electronic Resource
    A case of agammaglobulinemia characterized by a defect of B-lymphocyte-differentiation to plasma cells (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 527-530 
    Details
    ISSN: 1432-1440
    Keywords: Agammaglobulinemia ; demonstration of B-lymphocytes ; function of lymphocytes in-vitro ; family study ; Agammaglobulinämie ; B-Lymphocytennachweis ; Lymphocytenfunktion in-vitro ; Familienstudie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei einem 36jährigen Patienten mit einer kompletten Agammaglobulinämie und seinen Verwandten wurden humorale und celluläre Immunität untersucht. Im Knochenmark des Patienten fehlten die Plasmazellen. Sowohl die positiven Hautreaktionen gegenüber PPD und Tetanustoxoid als auch die Stimulation der peripheren Lymphocyten mit PHA deuten auf ein intaktes T-Zellsystem hin. Der Anteil der B-Lymphocyten im peripheren Blut war normal. Dieser Befund korreliert mit einer normalen Stimulationsrate mit Anti-IgG-Serum. Die Befunde sprechen für eine Reifungsstörung der B-Lymphocyten zu Plasmazellen.
    Notes: Summary Humoral and cell-mediated immune reactions of a 36-year old patient with a late onset of an agammaglobulinaemia and of his immediate relatives have been investigated. The immunoglobulins gamma-G, gamma-A, gamma-M, gamma-E and gamma-D, and plasma cells in the bone marrow could not be detected in the patient's serum. Immune reactions with PPD and tetanus toxoid as well as the stimulation of the lymphocytes with PHA indicate that the T-cell system was intact. The examination of the peripheral blood lymphocytes by immunofluorescence techniques gave a normal number of B-lymphocytes. These findings could be corroborated by the results of lymphocyte stimulations with anti-IgG. The data suggest that the maturation of the B-lymphocytes to plasma cells may be disturbed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468723
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    HLA antigen frequencies in patients with huntington's chorea and their relatives (1980)
    Springer
    Journal of neurology 223 (1980), S. 119-125 
    Details
    ISSN: 1432-1459
    Keywords: HLA antigens ; Huntington's chorea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 20 Patienten mit Chorea Huntington und 30 Angehörigen wurden 30 HLA-Antigene der A-, B- und C-Serie bestimmt. Es fand sich eine Frequenzvermehrung von HLA-BW 16, die auf dem 1%-Niveau signifikant war. Nach einer Korrektur für statistische Fehler ersten Grades bestand keine Signifikanz mehr. Auch bei den Familienuntersuchungen fand sich kein sicherer Hinweis für eine Kopplung der HLA-Antigene mit dem Choreagen.
    Notes: Summary Twenty patients with Huntington's chorea and 30 family members were typed for 30 antigens of the HLA-A, B, and C series. There was an increased frequency of HLA-BW 16, significant at the 1%-level. After correcting for multiple inferences, the association of HLA-BW 16 with Huntington's chorea was no longer statistically significant. There was also no reliable indication of coupling between HLA antigens and Huntington's chorea in the family studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313174
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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