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  • Rat  (3)
  • Bryomol ramps  (2)
  • Algodystrophy  (1)
  • 1
    ISSN: 0196-9781
    Keywords: Bifunctional reagents ; Cross-linking ; Human ; Monoclonal antibodies ; Rat ; Receptor mediated endocytosis ; Receptors ; VIP ; Vasoactive intestinal peptide
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1437-3262
    Keywords: Miocene ; Palaeoceanography ; Climatic changes ; Sea-level fluctuations ; Chlorozoan reefs ; Bryomol ramps
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract In order to evaluate the geological record of climatic change in neritic carbonates, we studied Late Miocene rock outcrops in southern Spain. Six episodes of reef growth are documented (Burdigalian to Messinian) in Neogene basins of the Betic Cordillera, which were located close to the margin of the global reef belt. The reefs are characterized by various zooxanthellate corals which decrease in diversity with time, andHalimeda; the youngest reefs of the latest Messinian are characterized by the dominance of the genusPorites. Late Miocene coral reefs and reef-rimmed platforms alternate over time with non-reefal carbonate ramps characterized by skeletal calcirudites or with gypsum such as that formed during the Messinian salinity crisis. The calcirudites lack reef corals, calcified green algae and extensive marine cement, but exhibit skeletal components described from both modern and fossil nontropical carbonates. These include bryozoans, mollusks, foraminifers, echinoderms and minor balanids, as well as coralline algae of a bryomol association. The presence of some larger foraminifers indicates high temperatures, close to the lower temperature threshold of the reef assemblage. Sea level lowstands and highstands are documented by wedges of bryomol carbonate and chlorozoan patch reefs or prograding platforms. Thus, temperate climate depositional modes correspond to relatively low sea levels, and warm-water modes to high sea levels. The Neogene infill of the Agua Amarga and Sorbas basins documents two of these cycles. Other climate/sea-level cycles (including Messinian gypsum in the cool water depositional mode) are well established in adjacent Neogene basins in southern Spain. This type of composite sequence seems to occur only along the margin of the global reef belt and indicates an oscillatory latitudinal movement of the margin, which is associated with global climatic change. The analysis of turnover in neritic depositional carbonate systems may therefore be considered a sensitive tool for reconstructing climatic change from the fossil record. However, warm-water modes and temperate-water modes of carbonate sedimentation and diagenesis differ significantly. For this reason the interpretation of composite system sequences by sequence stratigraphy requires an extended concept. The particular type of mixed bryomolchlorozoan depositional sequence also bears some potential for drowning, because sea level rise may be faster than the net production rate of temperate carbonate systems.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 26 (1984), S. 297-299 
    ISSN: 1432-0428
    Keywords: Rat ; pathogenesis ; insulin-dependent diabetes ; dietary proteins ; milk proteins ; wheat proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Animals from a colony of spontaneously diabetic insulin-dependent BB rats were fed from weaning with semisynthetic diets in which natural proteins were replaced by l-amino acids with or without the addition of either milk or wheat proteins. The normal 50% incidence of diabetes in the colony was reduced to 15% in rats fed the basic semi-synthetic diet, while it was 35% and 52% when supplemented with gluten or milk, respectively. Thus, dietary factors might precipitate the expression of the disease.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1912
    Keywords: Guanfacine ; Clonidine ; Continuous infusion ; Withdrawal ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In conscious unrestrained spontaneously hypertensive and normotensive rats, prepared with permanently indwelling abdominal aortic catheters, the effects on blood pressure and heart rate of a 12-day continuous subcutaneous infusion of guanfacine (10 mg/kg/day) and clonidine (500 μg/kg/day) and sudden interruption of these treatments were studied. Both drugs significantly and consistently reduced the mean arterial pressure and heart rate throughout the infusion period in the SH rats, but not in the normotensive animals. The magnitude of the effects of both drugs in the SH rat were similar. Following withdrawal of treatment with guanfacine, a discontinuation syndrome was evoked, much less severe than that observed after suspension of the infusion with clonidine. The withdrawal syndromes were characterized by an overshoot of heart rate and a period of blood pressure lability. In spite of the ineffectiveness of guanfacine and clonidine to reduce blood pressure and heart rate consistently in the normotensive rat, similar withdrawal patterns as those found in the SH rat were observed. These findings are in general agreement with the results previously found in clinical studies in hypertensive patients. The spontaneously hypertensive rat may prove a suitable animal model for pre-clinical studies of discontinuation symptoms after cessation of treatment with antihypertensive drugs.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Clinical rheumatology 8 (1989), S. 104-108 
    ISSN: 1434-9949
    Keywords: Reflex Sympathetic Dystrophy ; Algodystrophy ; Transient Regional Osteoporosis ; Migratory Osteolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Reflex sympathetic dystrophy (RSD) is a clinical syndrome defined in the English literature by pain, dystrophic tissue changes and local disturbance of autonomic function in a limb or part of a limb. Algodystrophy is the common name used for the condition in the French literature, in which the concept also includes the “transient regional osteoporosis” and the “regional migratory osteolysis”. We want to discuss three points: 1) Are the RSD, transient regional osteoporosis and migratory osteolysis different diseases or different manifestations of a single condition ? We believe that an objective differentiation is not possible between them. Our report about 28 cases of polytopic RSD shows the frequent association in the same patient of these manifestations and we believe that this represents the broad spectrum of a single disease. 2) Is the accepted classic pathophysiologic mechanism of RSD accurate? The conception of a disturbance of autonomic function is not easily linked with its association with conditions such as diabetes, hyperthyroidism, hyperlipidaemia and others. Even more difficult to explain is the association with malignancy and osteomalacia. The deposit of immunoglobulins that we have demonstrated in two cases in the palmar fascia of RSD associated with malignancy suggests a possible immunological mechanism. 3) What are the limits of RSD? The association between RSD and aseptic necrosis of the hip has been reported. Are they two different conditions or is the aseptic necrosis only a more developed form of RSD? Finally, we report the first single case of Munchausen syndrome mimicking a RSD of the hand with the same clinical, radiological and scintographic appearance.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0016-7835
    Keywords: Key words Miocene ; Palaeoceanography ; Climatic changes ; Sea-level fluctuations ; Chlorozoan reefs ; Bryomol ramps
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  In order to evaluate the geological record of climatic change in neritic carbonates, we studied Late Miocene rock outcrops in southern Spain. Six episodes of reef growth are documented (Burdigalian to Messinian) in Neogene basins of the Betic Cordillera, which were located close to the margin of the global reef belt. The reefs are characterized by various zooxanthellate corals which decrease in diversity with time, and Halimeda; the youngest reefs of the latest Messinian are characterized by the dominance of the genus Porites. Late Miocene coral reefs and reef-rimmed platforms alternate over time with non-reefal carbonate ramps characterized by skeletal calcirudites or with gypsum such as that formed during the Messinian salinity crisis. The calcirudites lack reef corals, calcified green algae and extensive marine cement, but exhibit skeletal components described from both modern and fossil non-tropical carbonates. These include bryozoans, mollusks, foraminifers, echinoderms and minor balanids, as well as coralline algae of a bryomol association. The presence of some larger foraminifers indicates high temperatures, close to the lower temperature threshold of the reef assemblage. Sea level lowstands and highstands are documented by wedges of bryomol carbonate and chlorozoan patch reefs or prograding platforms. Thus, temperate climate depositional modes correspond to relatively low sea levels, and warm-water modes to high sea levels. The Neogene infill of the Agua Amarga and Sorbas basins documents two of these cycles. Other climate/sea-level cycles (including Messinian gypsum in the cool water depositional mode) are well established in adjacent Neogene basins in southern Spain. This type of composite sequence seems to occur only along the margin of the global reef belt and indicates an oscillatory latitudinal movement of the margin, which is associated with global climatic change. The analysis of turnover in neritic depositional carbonate systems may therefore be considered a sensitive tool for reconstructing climatic change from the fossil record. However, warm-water modes and temperate-water modes of carbonate sedimentation and diagenesis differ significantly. For this reason the interpretation of composite system sequences by sequence stratigraphy requires an extended concept. The particular type of mixed bryomol–chlorozoan depositional sequence also bears some potential for drowning, because sea level rise may be faster than the net production rate of temperate carbonate systems.
    Type of Medium: Electronic Resource
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