ISSN:
1434-4726
Keywords:
Cartilage
;
Allogeneic transplantation
;
Human immunodeficiency virus infections
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Human immunodeficiency virus (HIV) infections are mainly transferred by blood, semen or organ transplantations. Since allogenic transplants have an established place in reconstructive surgery, the possibility of transferring HIV with such transplants has been a subject of much concern. Postmortem cartilage samples were obtained from eight HIV-infected patients and examined using the polymerase chain reaction in order to detect proviral HIV-1 DNA (gag, pol, env). Blood, brain and spleen samples were also obtained and used as positive controls. Results showed that no cartilage sample contained any HIV-DNA, whereas proviral sequences were clearly demonstrated in perichondrium from six patients. These findings indicate that HIV is not present in cartilage of HIV-infected patients, making HIV transmission through cartilage grafting improbable when transplants from HIV-negative donors are used.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00171543
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