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  • 1
    Electronic Resource
    Electronic Resource
    Effects of dorsal root entry zone lesions on CSF and plasma neuropeptides and catecholamines (1992)
    Springer
    Acta neurochirurgica 117 (1992), S. 38-43 
    Details
    ISSN: 0942-0940
    Keywords: Dorsal root entry zone lesion ; neuropeptides ; catecholamines ; CSF
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Effects of dorsal root entry zone lesions (DREZLs) on cerebrospinal fluid (CSF) and plasma concentrations of neuropeptides, catecholamines, and cyclic nucleotides were studied in 9 patients with intractable chronic pain. Contents of β-endorphin-like-material in CSF decreased in all patients 12–17 days following DREZLs during which complete to good pain relief was achieved. Contents of β-endorphin-like-material in CSF increased again about one month after DREZLs in two and remained unchanged in one of three patients tested, who complained of partial reappearance of pain. Contents of β-endorphin-like-materials in plasma showed no significant changes after DREZLs. Substance P, noradrenaline, adrenaline, and cyclic nucleotide levels in both CSF and plasma were variable among the subjects and did not change significantly following the operations. Thus, the results suggest that production of β-endorphin-like-material in the central nervous system is decreased by DREZL, though the increase in its turn-over might not be neglected. The mechanisms of the decrease in contents of β-endorphin-like-material in CSF after DREZLs were discussed in terms of our current knowledge of pain and pain inhibitory systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400633
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of age on venodilator effect of isoproterenol and amrinone (1996)
    Springer
    European journal of clinical pharmacology 50 (1996), S. 37-40 
    Details
    ISSN: 1432-1041
    Keywords: Key words Isoproterenol ; Amrinone ; Elderly; venodilation ; age-related change ; dorsal hand vein technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: To investigate the influence of age on the venodilator effect of isoproterenol, a β-adrenoceptor agonist, and amrinone, a selective phosphodiesterase (PDE) III inhibitor, in human subjects. Methods: In eight young and eight elderly male subjects, the drugs were infused into a dorsal hand vein preconstricted with phenylephrine and its diameter was measured using a linear variable differential transformer. Results: The maximum venodilation (Emax) induced by isoproterenol was significantly smaller and the infusion rate of isoproterenol required to induce 50% of maximum venodilation (ED50) was significantly larger in the elderly than in the young subjects [Emax: 29.8 vs 95.1%, ED50: 97.3 vs 51.6 ng ⋅min–1]. A significant age-related change in Emax or ED50 was not observed for amrinone (Emax: 95.8 vs 100.8%, ED50: 40.1 vs 31.6 μg ⋅min–1). Conclusion: The data show that the venodilator effect of amrinone is not influenced by age. As amrinone increases cyclic AMP by inhibition of PDE III, it is suggested that the action of cyclic AMP is not altered by age. The decreased effect of isoproterenol might be caused by reduced production of cyclic AMP in elderly subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050066
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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