Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    The thickness of the subchondral plate and its correlation with the thickness of the uncalcified articular cartilage in the human patella (1995)
    Springer
    Anatomy and embryology 192 (1995), S. 437-444 
    Details
    ISSN: 1432-0568
    Keywords: Subchondral bone ; Cartilage thickness ; Functional adaptation ; Morphometry ; Methyl methacrylate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The regional thickness distributions of the subchondral plate and the unmineralized part of the articular cartilage were morphometrically determined in normal human patellae, and the correlation coefficient for each specimen calculated from the paired measurements. For this purpose the patellae were embedded in methyl methacrylate and cut as serial sections, which were assessed with a Vidas image-analyzing system (Kontron). The values obtained were used to reconstruct the individual and average thickness distributions and to calculate the correlation coefficients for each subject. Both the thickness of the subchondral plate and that of the cartilage revealed regular distributions which, however, followed different patterns. Central regions with maximum values from which the thickness decreased concentrically towards the periphery were found in both. However, the distribution patterns of the unmineralized cartilage and the subchondral plate could be clearly distinguished, both by the position of the maxima and by the arrangement of the isocrassids (contour lines of equal thickness). The thicknesses of the two tissues showed a correlation between 0.38 and 0.82 (mean 0.6). We attribute this to their different reactions to the type of stress acting upon them. It appears that the thickness of the subchondral plate is principally determined by stresses acting over a longer period of time with low frequency, whereas the thickness of the articular cartilage seems to be a response to intermittent dynamic stresses of a higher frequency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00240376
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Granulocyte-activating mediators (GRAM): III. Further functional characterization of monocyte-derived GRAM (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 346-353 
    Details
    ISSN: 1432-069X
    Keywords: Granulocyte ; Cytokines ; Superoxide ; Oxygen radicals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary As shown previously monocytes upon stimulation with bacterial lipopolysaccharides (LPS) release granulocyte-activating mediator(s) (M-GRAM) which induced a long-lasting chemiluminescence (CL) response in human granulocytes. M-GRAM could be separated from interleukin-1α and β, interleukin-2, interferon α and γ, granulocyte colony stimulating factor (G-CSF) and macrophage colony stimulating factor (M-CSF), since these cytokines were shown to be unable to induce a significant CL response. In contrast, granulocyte macrophage colony stimulating factor (GM-CSF) and particularly tumor necrosis factor (TNF) are important triggers of the oxidative burst and they are capable of inducing a CL response. TNF activity but not lymphotoxin (LT) activity could be demonstrated in M-GRAM samples. A polyclonal rabbit IgG as well as a monoclonal antibody to recombinant human TNF which neutralized the TNF activity in M-GRAM preparations did not substantially block the CL signal. Furthermore, M-GRAM-induced CL response was not significantly inhibited by a polyclonal calf antiserum to human recombinant GM-CSF. For further functional characterization of M-GRAM-induced granulocyte activation different assays were performed in order to compare GM-CSF and TNF: (a) SOD-inhibitable cytochrome C-reduction (.O2 -); (b) horse radish peroxidase-mediated oxidation of phenol red (H2O2); (c) the release of peroxidase; (d) ultrastructural detection of hydrogen peroxide production; and (e) scanning and transmission electron microscopy (SEM and TEM). Significant release of .O2 - was induced by M-GRAM, TNF, and GM-CSF, whereas H2O2 production was significantly stimulated only by M-GRAM and TNF, as shown by functional and ultrastructural assays. In contrast, only M-GRAM was able to induce significant release of peroxidase. Granulocyte activation could be visualized by SEM and TEM. Upon stimulation with M-GRAM polymorphonuclear neutrophilic granulocytes (PMN) showed an increased adherence to the substratum, developing an increased number of intracytoplasmic vacuoles and short filopodia, whereby the morphological pattern was different from that induced by GM-CSF and TNF. Based on our results we suggest that M-GRAM activity is mediated, in addition to TNF, by a possible new cytokine which is capable to specifically activate granulocytes turning them into scavengers of invading microbes and parasites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426612
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Anatomie und Funktion des Beckenbodens (2000)
    Springer
    Der Radiologe 40 (2000), S. 429-436 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Beckenboden ; Anatomie ; Schnittbildanatomie ; Funktion ; Key words Pelvic floor ; Anatomy ; Anatomic planes ; Shape ; function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Pelvic floor. Anatomy of the pelvic floor seemed to be clearly. In opposite the physiology of the Levator ani and the endopelvic fascia is not yet fully understood. Especially the anatomic form of the levator plate does not conform with physiologic concepts. Pelvic structures. Pelvic structures can be divided in three groups: the hollow organs, the endopelvic fascia and the muscles. The M. levator ani is the muscle of the pelvic diaphragm. Its parts were given different names (Fig. 1, 4) depending on their function or localization. In anatomic studies the pelvic floor is described as bassin-shaped. In contrast to the anatomic results based upon the evaluation of cadavers, dynamic MRI gave different concepts: at rest the levator ani probably has the shape of a dome and differ when contract. The urogenital diaphragm is mostly a fascia and containts only fair muscular components. Therefore, many authors do not accept the term “diaphragm” and the physiologic function is still a matter of discussion. The endopelvic fascia has to fix the organs in the pelvis and forms “streets” for vascular and nervous supply. Conclusion. Describing anatomic structures in the common planes (transversal, sagittal, frontal) will help to understand CT- and MRI-imaging.
    Notes: Zusammenfassung Beckenboden. Der Beckenboden ist muskulär-bindegewebiger Abschluss der abdominalen Körperhöhle. Neben dem Aufrechterhalten einer kontinuierlichen Kontraktion zur Sicherung einer physiologischen Organtopographie hat er eine wichtige Bedeutung für den Erhalt der Kontinenz. Strukturgruppen. Im kleinen Becken finden sich im Wesentlichen 3 anatomisch und funktionell unterschiedliche Strukturgruppen: die Hohlorgane des Urogenitalsystems und das Rektum, das rhabdomuskuläre System der quer gestreiften Muskeln und das Beckenbindegewebe mit dem lissomuskulären System aus quer gestreiften und glatten Muskelfasern. Die Muskeln des Beckenbodens bestehen im Wesentlichen aus dem M. levator ani mit seinen Anteilen und dem Diaphragma urogenitale. Aus anatomischer Sicht wird die Form des Beckenbodens im Allgemeinen mit einem nach hinten flacher werdenden Trichter verglichen. Dynamische MRT-Untersuchungen stellen dies in Frage und lassen ihn – je nach Spannungszustand – als Platte oder sogar nach kranial gewölbt erscheinen. Beckenbindegewebe. Das Beckenbindegewebe ist heterogen zusammengesetzt. Es enthält Gefäße und Nerven sowie Konglomerate glatter Muskelzellen. Neben einer gewissen Fixierung der inneren Organe stellt es die Leitstrukturen f¨r Blutversorgung und Innervation dar. Resümee. Abgesehen von einer Übersicht über die anatomischen Verhältnisse bei der Frau wird v. a. die Schnittbildanatomie präsentiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050692
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...