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  • Antemortal alternation, catecholamine and serotonin in mouse brain  (1)
  • Key words: Attenuation, crust, frequency dependence, high-frequency seismic waves, quality factor.  (1)
  • Keywords Insulin gene  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Frequency-dependent Attenuation of High-frequency P and S Waves in the Upper Crust in Western Nagano, Japan (1998)
    Springer
    Pure and applied geophysics 153 (1998), S. 489-502 
    Details
    ISSN: 1420-9136
    Keywords: Key words: Attenuation, crust, frequency dependence, high-frequency seismic waves, quality factor.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract —Borehole seismograms from local earthquakes in the aftershock region of the 1984 western Nagano Prefecture, Japan earthquake were analyzed to measure the frequency-dependent characteristics of P- and S-wave attenuation in the upper crust. The records from a three-component velocity seismometer at the depth of 145m exhibit high S/N-ratio in a wide frequency range up to 100 Hz. Extended coda normalization methods were applied to bandpass-filtered seismograms of frequencies from 25 to 102 Hz. For the attenuation of high-frequency P and S waves, our measurements show Q P -1≃ 0.052ƒ-0.66 and Q S -1≃ 0.0034ƒ-0.12 respectively. The frequency dependence of the quality factor of S waves is very weak as compared with that of P waves. The ratio of Q P -1/Q S -1 is larger than unity in the entire analyzed frequency range.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000240050205
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  • 2
    Electronic Resource
    Electronic Resource
    Central monoamines and the death process time (antemortem time) during asphyxia (1984)
    Springer
    International journal of legal medicine 93 (1984), S. 211-218 
    Details
    ISSN: 1437-1596
    Keywords: Monoamines, asphyxia ; Antemortal alternation, catecholamine and serotonin in mouse brain ; Ersticken, Konzentrationsänderung der Monoamine ; Monoamine, Verhalten bei Asphyxie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Konzentrationsänderung der Monoamine Norepinephrin (NE), Dopamin (DA) und Serotonin (5-HT) im Gehirn wurde während der akuten Asphyxie (Strangulation, Anoxie und Ertrinken) experimentell an Mäusen untersucht. In verschiedenen Versuchsgruppen wurde eine signifikante, lineare Abhängigkeit der Monoamin-Werte NE, DA, und 5-HT zur Länge des agonalen Stadiums beobachtet, wobei folgende Korrelationskoeffizienten errechnet wurden: r=0,50, 0,98, (P〈0,05) und 0,57. Hieraus wird geschlossen, daß die Konzentration des NE und 5-HT im Gehirn bei den asphyktischen Tieren zunimmt, die das 5-HT bei den Tieren unter Anoxie abfällt, hingegen einen etwa zweifachen Anstieg bei den Tieren aufweist, die ertranken. Darüber hinaus ließ sich eine Tendenz zu höheren DA-Werten feststellen, die in Abhängigkeit zur Länge der agonalen Phase steht.
    Notes: Summary The changes of the brain monoamines, norepinephrine (NE), dopamine (DA), and serotonin (5-HT), during acute asphyxia, caused by strangulation, anoxia, and drowning, were studied in the mouse. In several asphyxiated animal groups significant linear correlation was found between the level of monoamines, NE, DA, and 5-HT, and the death process times or antemortem times were r=0.50, 0.98 (P〈0.05), and 0.57, respectively. It is concluded that the level of brain NE and DA increased in the mouse that died of asphyxia, and the level of 5-HT showed only an apparent decrease in anoxia groups as compared with the control group and showed a twice as high increase in drowning groups. Especially, there was a tendency that the longer the death process times or antemortem times, the higher was the level of DA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00200452
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  • 3
    Electronic Resource
    Electronic Resource
    GGAAAT motifs play a major role in transcriptional activity of the human insulin gene in a pancreatic islet beta-cell line MIN6 (1996)
    Springer
    Diabetologia 39 (1996), S. 1462-1468 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Insulin gene ; GG motif ; transcription ; pancreatic islet ; MIN6.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The insulin gene is specifically expressed in pancreatic islet beta cells. Various cis-acting DNA elements in the 5 ′-flanking region of the human insulin gene were examined for their contribution to the transcriptional activity using sensitive human growth hormone (hGH) reporter plasmids. The hGH constructs, having successively deleted human insulin promoter sequences, were transfected to a pancreatic islet beta-cell line MIN6. The deletion of two GGAAAT (GG) motifs, GG2 at –145 to –140 bp and GG1 at –134 to –129 bp, decreased the transcriptional activity to 6.5 % of that of the promoter sequence from –156 to + 1 bp. The selective mutations in both GG motifs also decreased the transcriptional activity to 5.5 %. One-base mutations of GG2 and GG1 decreased the transcriptional activity to 82 and 11 %, respectively. The two-base mutations between GG2 and GG1 affected the transcriptional activity more strongly than those just outside the GG motifs. A single set of GG motifs in the upstream of thymidine kinase promoter increased the transcriptional activity to 216 % compared to that of thymidine kinase promoter alone in MIN6 cells. With an electrophoretic mobility shift assay (EMSA), a nuclear factor in MIN6 cells was shown to bind the DNA fragments containing two GG motifs. This factor did not bind to another GGAAAT-like sequence at –313 to –305 bp in the human insulin gene. These results suggested that the GG motifs contributed to the cell-specific transcription of the human insulin gene in association with the binding of the sequence-specific nuclear factor. [Diabetologia (1996) 39: 1462–1468]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050599
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    Paper (German National Licenses)
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