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  • Patch clamp  (5)
  • Ultrasound  (5)
  • Apomorphine  (4)
  • 1
    Digitale Medien
    Digitale Medien
    Pancreatic carcinoma in a neonate (1983)
    Springer
    Pediatric radiology 13 (1983), S. 284-286 
    Details
    ISSN: 1432-1998
    Schlagwort(e): Neonate-adenocarcinoma ; Computed tomography ; Pancreas ; Ultrasound
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The clinical and radiographic findings in a neonate with adenocarcinoma of the head of the pancreas are presented. CT revealed the mass to be well defined, with an inhomogeneous density before and after intravenous contrast enhancement. Ultrasound revealed the mass to be mainly densely echogenic with small, irregular, echo-free areas. The portal vein was intimately applied to the posterior aspect of the mass. The literature concerning adenocarcinoma of the pancreas in the pediatric age group is reviewed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00973349
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  • 2
    Digitale Medien
    Digitale Medien
    Biliary disease in metachromatic leukodystrophy (1983)
    Springer
    Pediatric radiology 13 (1983), S. 313-318 
    Details
    ISSN: 1432-1998
    Schlagwort(e): Biliary tract ; Metachromatic leukodystrophy ; Ultrasound
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This paper illustrates the previously unreported sonographic changes in the biliary tract in metachromatic leukodystrophy (MLD). Gallbladder wall thickening due to sulfatide deposition, intraluminal globules of sulfatide or papillomatosis may cause symptoms referrable to the biliary tract in these patients. A series of patients whom, we have studied is briefly alluded to in order to bring to the attention of the radiologist MLD as a rare cause of biliary disease in children.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01625956
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  • 3
    Digitale Medien
    Digitale Medien
    Hypoxic/ischaemic cerebral injury in the neonatal brain (1983)
    Springer
    Pediatric radiology 13 (1983), S. 307-312 
    Details
    ISSN: 1432-1998
    Schlagwort(e): Ultrasound ; Neonate ; Hypoxic/ischaemic lesion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Ultrasound has been used in 11 neonates whose history or clinical features suggested the possibility of hypoxic/ischaemic lesions. The ultrasound findings were correlated with computed tomographic findings in nine infants and with pathological findings in two. On ultrasound scan, areas of increased echoes represented both hypoxic/ischaemic and haemorrhagic lesions. However, the distinction between them could not be made with certainty. Cystic changes were shown clearly by ultrasound as were cerebral vascular pulsations in and adjacent to the areas of increased echoes. With computed tomography, hypoxic/ischaemic lesions were represented by areas of decreased density and haemorrhagic lesions by areas of increased density. Computed tomography failed to clearly demonstrate the cystic changes. Three types of lesions, viz. diffuse, focal and periventricular were based on the location of brain injury, the former two occurring in term infants and the latter in premature infants. Ultrasound has been shown to be of value for definition of the site and extent of hypoxic/ischaemic cerebral lesions in the newborn and for observation of their evolution.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01625955
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  • 4
    Digitale Medien
    Digitale Medien
    Ability of 3-carboxysalsolinol to produce ethanol-like discrimination in rats (1980)
    Springer
    Psychopharmacology 68 (1980), S. 277-281 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Drug discrimination ; Ethanol ; Apomorphine ; Salsolinol
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The purpose of the present study was to investigate the possible generalization to 3-carboxysalsolinol (3C-SAL) in a group of rats trained to discriminate a low dose of ethanol (200 mg/kg IP) from the nondrug condition and in another group trained to discriminate 0.16 mg/kg IP apomorphine (AP) from the nondrug condition using a drug discrimination paradigm. In test sessions, ED50 for ethanol was 52.0 mg/kg and ED50 for AP was 0.01 mg/kg. In the ethanol-trained rats, 1.8 mg/kg 3C-SAL produced drug responses. In the AP-trained rats, 200 mg/kg ethanol produced drug responses whereas 1.8 mg/kg 3C-SAL produced only a partial drug response. The results are in harmony with the hypothesis that salsolinol in the central nervous system of the rat may be responsible for the discriminability of ethanol. The possible involvement of dopaminergic systems is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00428115
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  • 5
    Digitale Medien
    Digitale Medien
    Congenital epithelial splenic cysts in children (1982)
    Springer
    Pediatric radiology 12 (1982), S. 119-125 
    Details
    ISSN: 1432-1998
    Schlagwort(e): Spleen ; Cysts ; Ultrasound ; Abdomen ; Mass
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The clinical, radiographic and sonographic features of four children with congenital epithelial splenic cysts are described. All four cases presented with a left upper quadrant mass and few symptoms. In one case the spleen descended into the pelvis in the upright position. In three cases the sonographic findings showed the mass to be completely sonolucent. In the fourth case the mass was echogenic and echoes were distributed homogeneously throughout the mass. These internal echoes were due to the presence of fat droplets within the cyst fluid. Internal echoes may also be due to hemorrhage into the cyst. In all four cases a rim of splenic tissue was visible around part of the cyst.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00971799
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  • 6
    Digitale Medien
    Digitale Medien
    Effect of apomorphine and nigrostriatal lesions on aggression and striatal dopamine turnover during morphine withdrawal: Evidence for dopaminergic supersensitivity in protracted abstinence (1974)
    Springer
    Psychopharmacology 34 (1974), S. 37-44 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Aggression ; Morphine Addiction ; Apomorphine ; Dopamine Receptors ; Receptor Supersensitivity ; Narcotic Abstinence ; Nigrostriatal Lesion ; Medial Forebrain Bundle Lesion ; Protracted Abstinence ; Dopamine Turnover
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Reliable aggression was seen in rats which were grouped 30 days after undergoing continuous withdrawal from morphine. This withdrawal aggression, associated with long-lasting effects of morphine dependence, was blocked by morphine or lesions of the nigrostriatal bundle, but not by lesions of the median forebrain bundle. When the nigrostriatal lesioned rats were treated with a small dose of apomorphine, the aggression was reinstated. Apomorphine reduced the turnover of dopamine in the 30-day withdrawn rats at doses which were ineffective in similarly housed non-dependent rats. These results suggest that animals undergoing protracted morphine abstinence show aggression due to a latent dopaminergic supersensitivity, similar to that previously reported during acute narcotic withdrawal.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00421218
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  • 7
    Digitale Medien
    Digitale Medien
    Dopaminergic mediation of the interoceptive cue produced by d-amphetamine in rats (1975)
    Springer
    Psychopharmacology 42 (1975), S. 185-193 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Amphetamine ; Dopamine ; Haloperidol ; State-Dependent Behavior ; Apomorphine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract After rats were trained to differentiate between the effects of d-amphetamine and saline in a state-dependent task, pretreatment with the tyrosine hydroxylase inhibitor, α-methyl-p-tyrosine, significantly decreased amphetamine discrimination. Pretreatment with the dopamine-Β-hydroxylase inhibitor, disulfiram, or with the tryptophan hydroxylase inhibitor, p-chloro-phenylalanine, was observed to have no effect on the rats' ability to discriminate d-amphetamine. Administration of haloperidol, a selective dopamine receptor blocker, completely abolished the amphetamine discrimination, whereas α- and Β-adrenergic receptor blockade had no effect. Apomorphine, a dopamine receptor stimulant, produced amphetamine-like responses and this was, likewise, abolished by pretreatment with haloperidol. These data suggest that dopaminergic systems mediate the interoceptive cue produced by d-amphetamine in rats, and these results are discussed in relation to possible dopamine mediation of amphetamine psychosis and paranoid schizophrenia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00429551
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  • 8
    Digitale Medien
    Digitale Medien
    Kinetic mode switch of rat brain IIA Na channels in Xenopus oocytes excised macropatches (1994)
    Springer
    Pflügers Archiv 427 (1994), S. 399-405 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Sodium channel ; Oocyte ; Patch clamp
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Na currents recorded from inside-out macropatches excised from Xenopus oocytes expressing the α subunit of the rat brain Na channel IIA show at least two distinguishable components in their inactivation time course, with time constants differing about tenfold (τ h1 = approx. 150 μs and τ h2 = approx. 2 ms). In excised patches, the inactivation properties of Na currents changed with time, favoring the faster inactivation kinetics. Analysis of the fast and slow current kinetics shows that only the relative magnitudes of τ h1 and τ h2 components are altered without significant changes in the time constants of activation or inactivation. In addition, voltage dependence of both activation and steady-state inactivation of Na currents are shifted to more negative potentials in patches with predominantly fast inactivation, although reversal potentials and valences remained unaltered. We conclude that the two inactivation modes discerned in this study are conferred by two states of Na channel the interconversion of which are regulated by an as yet unknown mechanism that seems to involve cytosolic factors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00374253
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  • 9
    Digitale Medien
    Digitale Medien
    Point mutations in IIS4 alter activation and inactivation of rat brain IIA Na channels in Xenopus oocyte macropatches (1994)
    Springer
    Pflügers Archiv 427 (1994), S. 406-413 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Sodium channel ; Oocyte ; Patch clamp
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Macroscopic currents of wild-type rat brain IIA (RBIIA) and mutant Na channels were recorded in excised patches from Xenopus oocytes. A charge deletion (K859Q) and an adjacent conservative mutation (L860F) in the second domain S4 membrane-spanning region differentially altered voltage sensitivity and kinetics. Analysis of voltage dependence was confined to Na currents with fast inactivation kinetics, although RBIIA and K859Q (but not L860F) also showed proportional shifts between at least two gating modes, rendering currents with fast or slow inactivation kinetics, respectively. Compared to RBIIA, the midpoint of the activation curve was shifted in both K859Q and L860F by 22 mV to more positive potentials, yet this shift was not associated with a corresponding change in the voltage dependence of time constants for activation (τ a) or inactivation (τ h1, τ h2). L860F showed faster activation time constants τ a than RBIIA, while K859Q was slower for both the activation (τ a) and the inactivation components (τ h1). Similarly, the steady-state inactivation curve of L860F but not K859Q shifted by 9 mV in the hyperpolarizing direction. Thus, the fourth charge in the IIS4 transmembrane segment exerts control over voltage sensitivity and kinetics of activation and may interact with structure that influence other aspects of channel gating.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00374254
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  • 10
    Digitale Medien
    Digitale Medien
    A direct-reading device for measurement of patch-clamp micropipette tip diameters (1990)
    Springer
    Pflügers Archiv 417 (1990), S. 255-258 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Micropipette ; Inner tip diameter ; Electronic device ; Patch clamp
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This paper describes an electronic device for the measurement of the diameter of the tip opening of micropipettes. The device measures the threshold pressure required to produce bubbles from the micropipette submerged in a liquid and displays the tip inner diameter in micrometres. We demonstrate that this technique can be used effectively in a range of liquids of different density, surface tension and viscosity and that the thickness of the glass from which the micropipettes are made does not influence the measurements.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00370989
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