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  • 1
    Electronic Resource
    Electronic Resource
    Overexpression of HSP70 prevents ultraviolet B-induced apoptosis of a human melanoma cell line (2000)
    Springer
    Archives of dermatological research 292 (2000), S. 482-487 
    Details
    ISSN: 1432-069X
    Keywords: Keywords HSP70 ; Human melanoma cells ; Ultraviolet B ; Apoptosis ; Caspase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The heat shock response is a highly conserved reaction common to all cells and organisms. It has been reported that hyperthermic treatment can induce the expression of the heat shock protein (HSP) and can protect cells from ultraviolet (UV) B radiation. In this study, we evaluated the effects of induced HSP70 on resistance to UV radiation. G361 amelanotic human melanoma cells were irradiated with increasing doses of UVB. UVB irradiation caused apoptotic cell death in these cells. Following transfection with MFG.hsp70.puro plasmid, the expression of HSP70 was determined. Compared to control vector-transfected cells, hsp70-transfected cells showed significantly elevated levels of HSP70 and were highly resistant to UVB irradiation. In order to investigate the effects of HSP70 on the apoptotic pathway, the changes in caspase-3 and PARP were analyzed. Following UVB irradiation, activation of caspase-3 and cleavage of PARP were observed in control vector-transfected cells, and the changes in these molecules were inhibited in the hsp70-transfected cells. These results suggest that UVB-induced apoptosis of melanoma cells is accompanied by caspase-3 activation and PARP cleavage, which can be prevented by an overexpression of HSP70.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030000173
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  • 2
    Electronic Resource
    Electronic Resource
    Clinical characteristics of Peutz-Jeghers syndrome in Korean polyposis patients (2000)
    Springer
    International journal of colorectal disease 15 (2000), S. 35-38 
    Details
    ISSN: 1432-1262
    Keywords: Keywords Peutz-Jeghers syndrome ; Hamartomatous polyps ; Intussusception ; Cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Peutz-Jeghers syndrome is an autosomal dominant inherited disorder characterized by hamartomatous polyps in the small bowel and mucocutaneous pigmentation. Patients with Peutz-Jeghers syndrome often present as surgical emergencies with complications of the polyps, such as intussusception, bowel obstruction, and bleeding. Recently an increased risk of malignancies has also been reported. This study was initiated to determine the clinical features of Peutz-Jeghers syndrome in Korean patients, with special attention to the development of malignancies. Thirty patients with Peutz-Jeghers syndrome were investigated; their median age was 23.5 years, and symptoms appeared at a median age of 12.5 years. Family history was positive in one-half of cases, and mucocutaneous pigmentation was observed in almost all patients (93%). The jejunoileum was the most frequent site of the polyps, and there were generally 10–100 polyps. Multiple laparotomies were performed in a substantial portion of the patients, due mainly to polyp-induced bowel obstruction, and the surgical interventions were begun at a relatively young age (average 21.4 years). Four cases of small-bowel cancer and one case of breast cancer were detected in probands, at a relatively young age (mean 36 years). Cancers of the small bowel, stomach, colon, breast and cervix were diagnosed in the first relatives of the probands. Close follow-up from an early age should thus be performed in patients with Peutz-Jeghers syndrome as they are at high risk of surgical emergency and development of malignancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003840050005
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  • 3
    Electronic Resource
    Electronic Resource
    Viscoelastic and rheological properties of concentrated solutions of proteoglycan subunit and proteoglycan aggregate (1990)
    New York : Wiley-Blackwell
    Biopolymers 29 (1990), S. 1587-1592 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The oscillatory and steady shear rheological properties of concentrated solutions of proteoglycan subunit (PGS) and aggregate (PGA) from bovine articular cartilage have been studied using a Rheometrics fluids spectrometer. At comparable concentrations in the physiological range tan δ increases from 0.5 to 1.0 for PGA as the oscillation frequency (ω) increases from 10-1 to 102 rads / s, compared to a decrease from 40 to 5 for PGS. Thus PGA solutions exhibit predominantly elastic response whereas those of PGS exhibit primarily viscous behavior. PGA solutions show pronounced shear-thinning behavior at all shear rates (γ) in the range 10-2 〈 γ (s-1) 〈 10 2, whereas PGS solutions exhibit predominantly Newtonian flow. For PGA, the small-strain complex viscosity η* (ω) is substantially smaller than the steady-flow viscosity η (γ) at comparable values of ω and γ. These observations indicate that the presence of proteoglycan aggregates leads to formation of a transient or weak-gel network. Since aggregation leads to a large increase in molecular hydrodynamic volume and hence in the relaxation times for macromolecular rotation, it appears that role of aggregate formation is to shift the linear viscoelastic response from the terminal viscous flow into the plateau elastomeric regime of relaxational behavior. Normal or pathological changes that produce a decrease in aggregation will result in a loss of elastomeric behavior of the proteoglycan matrix.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360291208
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  • 4
    Electronic Resource
    Electronic Resource
    Drag reduction characteristics of polysaccharide xanthan gum (1998)
    Weinheim : Wiley-Blackwell
    Macromolecular Rapid Communications 19 (1998), S. 419-422 
    Details
    ISSN: 1022-1336
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The turbulent drag reduction characteristics of the rod-like polysaccharide xanthan gum dissolved in water was investigated using a rotating disk apparatus. The ultrasonic degradation method was adopted to obtain polymer fractions of different molecular weights of xanthan gum for this study. The drag reduction curve was then plotted to observed the universal characteristics of xanthan gum, and the intrinsic concentration was found to be an extremely useful quantity in normalizing the drag reduction data for different molecular weights.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Comonomer enhancement effect of 1-hexene in ethylene copolymerization catalyzed over MgCl2/THF/TiCl4 catalysts (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 48 (1993), S. 721-730 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Homo- and copolymerization of ethylene were performed by using a catalyst system composed of TiCl4/THF/MgCl2 complex activated with AlEt3 at 70°C and 3 atm. To investigate the effect of the compositional difference of the catalyst on the rates of homo- and copolymerization and on the reactivity in ethylene-hexene copolymerization, a series of six catalysts with different compositions (Mg/Ti = 0.4-16.5) were prepared by coprecipitation. The catalytic activity in ethylene polymerization increased sharply with the Mg/Ti ratio from 21 (Mg/Ti = 0.4) to 1477 kg PE/g-Ti h (Mg/Ti = 16.5). The activity in copolymerization with 1-hexene also increased with Mg/Ti ratio. The values of r1 were 120, regardless of Mg/Ti ratios within the experimental error range. Enhancement of the polymerization rate by the addition of 1-hexene in the reaction medium was observed only for the catalysts of low Mg/Ti ratio. This unusual effect of 1-hexene on the polymerization rate was explained by chemical and physical processes that occurred during polymerization. © 1993 John Wiley & Sons, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1993.070480414
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