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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 62 (1984), S. 1102-1107 
    ISSN: 1432-1440
    Keywords: Anorexia ; Aromatic amino acids ; Branched-chain amino acids ; Dopaminergic neurons ; Neoplastic diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Studies in anorectic tumor-bearing rats indicate that anorexia is correlated to imbalances of neutral amino acids in blood and CNS. Consequently plasma amino acids of patients with neoplastic and non-neoplastic internal diseases were studied during phases of anorexia; special regard was given to the precursors of dopamine and serotonin. Anorectic patients were compared to non-anorectic patients with neoplasia. During anorexia, plasma levels of valine and leucine and hence the ratio of the molar concentrations of Val+Leu+Ile/Phe+Tyr were significantly decreased in each anorectic patient as compared to non-anorectic patients whose ratios were always within the normal ranges. As aromatic and branched-chain amino acids compete for penetration of the blood brain barrier, the decrease of the amino acid ratio may induce a raised flux of phenylalanine and tyrosine into the CNS which results in an increased activation of dopaminergic neurons — known to cause anorexia.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-8580
    Keywords: Calciumselective disc-electrodes ; Electrochemical multimeasurementsystem ; Ionized serum-calcium ; Calciumselektive Disk-Elektroden ; Elektrochemisches Multimeßsystem ; Ionisiertes Serum-Calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Anaerob gewonnene Serumproben von gesunden Probanden wurden simultan mit drei zu einem System verbundenen ionenselektiven Scheiben-Elektroden im Durchfluß (elektrochemisches Multimeßsystem) auf ihren Ca++-Gehalt untersucht. Zwei der Sensoren enthielten elektrisch geladene Liganden, der dritte einen neutralen Carrier. Verwendung von neutralen Liganden in ionenselektiven Elektroden führt zu einer erheblichen Steigerung der Selektivität gegenüber H+- und NH 4 + -Ionen sowie einer deutlichen Verbesserung der Meßwertstabilität, Reproduzierbarkeit und Anzeigegeschwindigkeit.
    Notes: Summary Anaerobically prepared serum samples from healthy subjects were simultaneously analysed for Ca++ in a flow-through-system of three ion selective disc-electrodes (electrochemical multimeasurementsystem). Two of the sensors contained electrically charged ligands, the third contained a neutral carrier. With neutral carriers an improvement of performance was noted in that there was a large increase in selectivity toward H+-and NH 4 + -ions and a distinct enhancement of reproducibility.
    Type of Medium: Electronic Resource
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