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  • 1
    Electronic Resource
    Electronic Resource
    Unexpected infant death attributable to cardiac tumor or cardiomyopathy (1990)
    Springer
    International journal of legal medicine 103 (1990), S. 335-343 
    Details
    ISSN: 1437-1596
    Keywords: Sudden unexpected infant death ; Tuberous sclerosis and multiple rhabdomyomas ; Histiocytoid cardiomyopathy ; Cardiac tumors ; Fibrous histiocytoma ; Unerwarteter Säuglings- und Kindstod ; Multiple Rhabdomyome und tuberöse Sklerose ; Fibröses Histiozytom ; Histiozytoide Kardiomyopathie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Wir berichten über drei unerwartete Kinds- bzw. Säuglingstodesfälle: Ein 13 Monate alter Junge starb unerwartet und ohne Krankheitszeichen. Er hatte nach der Geburt lediglich mäßige kardiale Symptome aufgewiesen. Im multiplen kardialen Rhabdomyomen wurden Arachnozyten nachgewiesen, die einzelne Myofibrillen und in geringem Umfang Myosin und Desmin enthielten. Eine tuberöse Sklerose wurde durch den Nachweis mikroskopisch kleiner GFAP positiver Gliome gesichert. Im Fall eines 4 Monate alten Jungen konnte durch den Nachweis von alpha-1-Anti-Chymotrypsin und Lysozym ein großes benignes fibröses kardiales Histiozytom diagnostiziert werden. Bei einem 2 Monate alten Mädchen wurde eine histiozytoide Kardiomyopathie durch Nachweis leptomerer Fibrillen und geringer Mengen von Desmin und Myosin gesichert.
    Notes: Summary The pathological findings, including immunohistochemical and electron microscopical findings, in three infants who died unexpectedly of cardiac tumor or cardiomyopathy are reported. The first was a 13-month-old boy with tuberous sclerosis and multiple rhabdomyomas of the heart, who presented with a postpartal cardiac murmur and moderate cardiomegaly. The further history was unknown. The rhabdomyoma nodules were composed of spider cells containing small amounts of desmin and myosin as well as isolated myofibrils. Microscopically small glioma nodules contained high amounts of GFAP. The second case, a boy 4 months of age, died of a large benign fibrous histiocytoma of the heart after an uneventful history. Tumor cells contained alpha-1-anti-chymotrypsin and lysozyme. The third case, a girl 2 months of age, died unexpectedly of histiocytoid cardiomyopathy. The affected cells contained fat droplets, glycogen granules, many leptomer myofibrils and small amounts of myosin and desmin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01263038
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Morphological, immunocytochemical and growth characteristics of three human glioblastomas established in vitro (1991)
    Springer
    Virchows Archiv 418 (1991), S. 281-293 
    Details
    ISSN: 1432-2307
    Keywords: Glioma antigens ; Epidermal growth factor receptor ; Nerve growth factor receptor ; Transferrin receptor ; Chromosomes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The human glioblastoma-derived cell lines 86HG-39, 87HG-28 and 87HG-31, used for the production of monoclonal antibodies (mAbs) against glioma-associated antigens (GAA), were characterized in terms of morphology, growth behaviour, chromosomes and antigen expression. In the primary tumours, differential expression of glial fibrillary acidic protein, S100 protein, Leu-7 and GAA as defined by mAbs MUC 2–39, MUC 2–63 and MUC 8–22 was demonstrated. Receptors for epidermal growth factor (EGFr) and nerve growth factor (NGFr) were found in many cells in short-term cultures, but the transferrin receptor (Tr) was found in only a few cells of 87HG-28. In permanent cell lines, differentiation antigens and EGFr decreased and Tr increased markedly. NGFr and GAA remained stable. Transplantation tumours of 86HG-39 were partly positive for Tr and GAA. Chromosomal analysis revealed that the 86HG-39 and 87HG-28 cell lines had a hypodiploid or diploid stem line with lines in the hypotetraploid to tetraploid region for 50 in vitro passages. The 87HG-31 cell line had chromosomal patterns in the hypotriploid to triploid region. A gain of chromosomes was seen in the groups C7, C8, C10, D14, F19, F20, G21, G22. The variability of antigens in these tumours and especially during long-term cultivation probably reveals an ability to influence the growth of malignant glioma cells via the respeective effector molecules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01600156
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Extracorporeal CO2-removal with a heparin coated artificial lung (1988)
    Springer
    Intensive care medicine 14 (1988), S. 578-584 
    Details
    ISSN: 1432-1238
    Keywords: Acute respiratory failure ; Anticoagulation ; Artificial lung ; Extracorporeal gas exchange
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Treatment of severe acute respiratory failure with extracorporeal gas exchange necessitating near complete systemic anticoagulation requires a delicate balance to be maintained between disseminated intravascular coagulation and hemorrhagic complications. The present study describes our first experience using a heparin coated extracorporeal artificial lung and circuitry during clinical extracorporeal CO2 removal. In spite of a partial thromboplastin time and activated clotting time within or close to the normal range, neither laboratory evidence for disseminated intravascular coagulation induced by the extracorporeal circuit nor thrombi in the pulmonary vasculature were found. Scanning electron microscopy of the heparin coated hollow fiber gas exchanger demonstrated only minor deposits on the surface. Use of a heparin coated artificial lung may enhance the margin of safety of extracorporeal gas exchange and ultimately broaden its indications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00263533
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Unexpected infant death attributable to cardiac tumor or cardiomyopathy (1990)
    Springer
    International journal of legal medicine 103 (1990), S. 335-343 
    Details
    ISSN: 1437-1596
    Keywords: Sudden unexpected infant death ; Tuberous sclerosis and multiple rhabdomyomas ; Histiocytoid cardiomyopathy ; Cardiac tumors ; Fibrous histiocytoma ; Unerwarteter Säuglings-und Kindstod ; Multiple Rhaödomyome and tuberose Sklerose ; Fibröses Histiozytom ; Histiozytoide Kardiomyopathie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Wir berichten fiber drei unerwartete Kinds- bzw. Säuglingstodesfälle: Ein 13 Monate alter Junge starb unerwartet and ohne Krankheitszeichen. Er hatte nach der Geburt lediglich mdBige kardiale Symptome aufgewiesen. Im multiplen kardialen Rhabdomyomen wurden Arachnozyten nachgewiesen, die einzelne Myofibrillen and in geringem Umfang Myosin and Desmin enthielten. Eine tuberose Sklerose wurde durch den Nachweis mikroskopisch kleiner GFAP positiver Gliome gesichert. Im Fall eines 4 Monate alten Jungen konnte durch den Nachweis von alpha- I-Anti-Chymotryp sin and Lysozym ein groβes benignes fibröses kardiales Histiozytom diagnostiziert werden. Bei einem 2 Monate alten Mädchen wurde eine histiozytoide Kardiomyopathie durch Nachweis leptomerer Fibrillen and geringer Mengen von Desmin and Myosin gesichert.
    Notes: Summary The pathological findings, including immunohistochemical and electron microscopical findings, in three infants who died unexpectedly of cardiac tumor or cardiomyopathy are reported. The first was a 13-month-old boy with tuberous sclerosis and multiple rhabdomyomas of the heart, who presented with a postpartal cardiac murmur and moderate cardiomegaly. The further history was unknown. The rhabdomyoma nodules were composed of spider cells containing small amounts of desmin and myosin as well as isolated myofibrils. Microscopically small glioma nodules contained high amounts of GFAP. The second case, a boy 4 months of age, died of a large benign fibrous histiocytoma of the heart after an uneventful history. Tumor cells contained alpha- I-anti-chymotrypsin and lysozyme. The third case, a girl 2 months of age, died unexpectedly of histiocytoid cardiomyopathy. The affected cells contained fat droplets, glycogen granules, many leptomer myofibrils and small amounts of myosin and desmin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00204454
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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