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  • 1
    ISSN: 1432-0584
    Keywords: Galactose-oxidase technique ; Surface glycoproteins ; Human leukocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study aimed to investigate high molecular weight surface glycoprotein (S-GP) patterns on various types of human leukocytes. S-GP were externally labelled by the Galactose-oxidase-NaB3H4 technique. Results based on the analysis of 120 samples derived from different types of normal and malignant leukocytes indicate that (i) the relative expression of high molecular weight S-GPs changes during haemopoietic cell differentiation and (ii) to some extent these changes enable the classification of human leukocytes.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 50 (1972), S. 484-486 
    ISSN: 1432-1440
    Keywords: Cytotoxic antibodies ; Lymphocytes ; Lupus erythematosus ; Cytotoxische Antikörper ; Lymphocyten ; Lupus erythematodes ; Autoantikörper
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Seren von Patienten mit Lupus erythematodes, mit primär chronischer Polyarthritis, mit lymphoproliferativen Erkrankungen sowie verschiedenen Erkrankungen mit antinucleären Antikörpern wurden auf das Vorhandensein von Antikörpern gegen autologe Lymphocyten, sog. „Lymphocytotoxine“ getestet. Diese Lymphocytotoxine konnten fast ausschließlich bei Patienten mit LE nachgewiesen werden. Von 12 Patienten mit LE fehlten diese Antikörper nur in einem Fall. Ihr Auftreten war unabhängig von der Aktivität der Erkrankung. Die Virusätologie als Ursache der Entstehung des LE wird diskutiert.
    Notes: Summary Sera of patients suffering from Lupus erythematosus (LE), rheumatoid arthritis, lymphoproliferative disorders and various diseases with a high incidence of antinuclear antibodies were investigated with regard to antibodies against autologous lymphocytes, the so called “lymphocytotoxins”. These lymphocytotoxins were detected almost exclusively in patients with LE. They were present in 11 of 12 patients with LE in active as well as in successfully treated cases. The etiology of the disease is discussed in the light of these findings.
    Type of Medium: Electronic Resource
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