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  • 1
    Electronic Resource
    Electronic Resource
    Enzymes of purine metabolism in lymphoid neoplasms, clinical relevance for treatment with enzyme inhibitors (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 467-474 
    Details
    ISSN: 1432-1440
    Keywords: Purine enzymes ; Lymphoma ; Leukemia, Diagnosis ; Treatment ; Deoxycoformycin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A few enzymes of the purine degradative pathway have proved valuable in diagnosis and treatment of lymphomas and lymphocytic leukemia. Of particular interest are the enzymes adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP) and ecto-5′-nucleotidase (5NT). Intact activities of ADA and PNP have been shown to be vital for lymphoid cells. During development, lymphoid precursors go through remarkable changes in the concentrations of these enzymes and the neoplasma derived from them show a “frozen” biochemical profile similar to the corresponding normal cell of origin. Knowledge of the role of these enzymes has led to the pharmacological use of enzyme inhibitors for the specific treatment of lymphoid neoplasms. This review concerns the enzymatic make-up of normal and neoplastic lymphocytes and exploitation of this knowledge for the treatment of lymphomas. Special emphasis will be put on the clinical use of an ADA-inhibitor, deoxycoformycin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01876167
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    2′-Deoxycoformycin (pentostatin) in hairy cell leukemia: Response in patients refractory to interferon alpha (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 975-979 
    Details
    ISSN: 1432-1440
    Keywords: Deoxycoformycin ; Hairy cell leukemia ; Refractory treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three patients with advanced hairy cell leukemia received low-dose deoxycoformycin treatment after failure to respond to therapy with interferon alpha. Patients 1 and 2 had progressive disease after splenectomy and subsequent treatment with recombinant interferon alpha (for 7 and 3 months, respectively). DCF was administered at 4 mg/m2 weekly for 3 weeks, and then once every week for 6 weeks. Patient 1 was in complete remission after 9 weeks of treatment and patient 2 in partial remission with normalization of peripheral blood counts. The third patient, also splenectomized, developed hepatotoxicity after therapy trial with interferon for 24 days and no objective improvement was observed at this stage. She subsequently responded to DCF treatment with improvements in blood counts and bone marrow. This report demonstrates that DCF is highly effective in hairy cell leukemia and non-cross-resistant with interferon alpha.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01717832
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Autologous transplantation of a bone marrow graft manipulated by chemoseparation to eliminate residual tumor cells (1983)
    Springer
    Annals of hematology 46 (1983), S. 89-93 
    Details
    ISSN: 1432-0584
    Keywords: Autologous bone marrow transplantation ; Acute leukemia ; 4-hydroperoxycyclophosphamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autologous bone marrow transplantation (ABMT) was performed in a 45-year-old male patient with AML in therapy-resistant first relapse including CNS-disease. The marrow graft was harvested 18 months before, at the beginning of first remission, and was subjected to an in-vitro incubation with 4-hydroperoxycyclophosphamide (4-HC) prior to cryopreservation to eliminate residual clonogenic tumor cells. After myeloablative therapy with high-dose Cyclophosphamide (CY), total body irradiation (TBI) and intrathecal application of Methotrexate (MTX), the manipulated marrow graft was reinfused. The myelopoietic reconstitution started already 6 days after ABMT and was completed 40 days thereafter. There is evidence for a complete remission in marrow and spinal fluid observed over a period of 4 months.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320664
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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