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  • 1
    Electronic Resource
    Electronic Resource
    Treatment of aplastic anemia with cyclosporin A, methylprednisolone, and antithymocyte globulin (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 1165-1170 
    Details
    ISSN: 1432-1440
    Keywords: Aplastic anemia ; Immunosuppressive treatment ; Antithymocyte globulin ; Cyclosporin A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-three patients with aplastic anemia (18/23 with severe aplastic anemia) were treated with an immunosuppressive regimen consisting of cyclosporin A (CsA) and methylprednisolone (MP) (n=7) or CsA, MP, and antithymocyte globulin (ATG;n=16). Nineteen patients are alive with a follow-up of 4 to 25 months; three patients died of infections and one of a gastrointestinal hemorrhage. Within 3 months, improvement of hematopoiesis was seen in 14 patients (61%). First signs of a response after 23 to 88 days were followed by complete remission in eight patients, partial remission in three patients, and minimal improvement in three patients. Two of the patients with only minimal improvement were treated with a second course of immunosuppression and reached a complete remission and partial remission. Interestingly, remission proved to be dependent on the continued administration of CsA in four of five patients with partial or complete remission who could be evaluated up to now. Thus, CsA must have been effective in the induction and/or maintenance of remission in three patients. This observation is a very strong argument for the role of T cells in the pathogenesis of at least some cases of aplastic anemia and warrants further evaluation of the role of CsA in the treatment of aplastic anemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728454
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  • 2
    Electronic Resource
    Electronic Resource
    2′-Deoxycoformycin (pentostatin) in hairy cell leukemia: Response in patients refractory to interferon alpha (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 975-979 
    Details
    ISSN: 1432-1440
    Keywords: Deoxycoformycin ; Hairy cell leukemia ; Refractory treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three patients with advanced hairy cell leukemia received low-dose deoxycoformycin treatment after failure to respond to therapy with interferon alpha. Patients 1 and 2 had progressive disease after splenectomy and subsequent treatment with recombinant interferon alpha (for 7 and 3 months, respectively). DCF was administered at 4 mg/m2 weekly for 3 weeks, and then once every week for 6 weeks. Patient 1 was in complete remission after 9 weeks of treatment and patient 2 in partial remission with normalization of peripheral blood counts. The third patient, also splenectomized, developed hepatotoxicity after therapy trial with interferon for 24 days and no objective improvement was observed at this stage. She subsequently responded to DCF treatment with improvements in blood counts and bone marrow. This report demonstrates that DCF is highly effective in hairy cell leukemia and non-cross-resistant with interferon alpha.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01717832
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  • 3
    Electronic Resource
    Electronic Resource
    HTLV III antibodies and immunological alterations in hemophilia patients (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 115-124 
    Details
    ISSN: 1432-1440
    Keywords: Hemophiliacs ; Human T-lymphotropic virus, type III (HTLV III) ; Immunological alterations ; Clotting factor concentrates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinical, immunological, and serological status of 28 patients with hemophilia A and of 13 patients with hemophilia B was investigated. Thirty-four patients were treated regularly by clotting factor concentrates and 7 patients had been substituted only 1 to 4 times. Almost all patients with severe hemophilia suffered from hepatopathy. No patient had clinical evidence of the acquired immunodeficiency syndrom (AIDS). Asymptomatic hemophiliacs showed a decreased number of T-helper (OKT 4) cells and an increased number of T-suppressor (OKT 8) cells, which resulted in an inversed OKT 4/OKT 8 cell ratio. Natural killer cell activity of all patients was decreased compared to controls. After culture there was no significant difference of NK cell activity between hemophiliacs and controls. This phenomen was interpreted as a possible maturation defect of NK-cells in vivo. No relationship between immunological alterations and hepatopathy, hepatitis markers, CMV antibodies, amount and source of required factor concentrates, and the kind of hemophilia was observed. IgG immunoglobulins were higher and the OKT 4/OKT 8 ratio lower in the eight patients with lymphadenopathy than in patients without lymphadenopathy. The prevalence of antibodies to human T-lymphotropic virus (HTLV III) was measured in 35 hemophiliacs and in 25 polytransfused patients, most of whom were suffering from acute leukemia. In 8 of 35 hemophiliacs antibodies to HTLV III virus were detected by an enzyme linked immunosorbent assay (ELISA) and confirmatory tests. All seropositive patients were treated by blood products from the United States. Eight hemophiliacs treated by factor concentrates from German donors only were seronegative. In comparison 2 of 25 examined non-hemophilia patients receiving multiple blood products from local donors were seropositive for HTLV III. The results show that hemophilia patients treated by imported clotting factor concentrates have a high risk of HTLV III positivity. Hemophiliacs substituted by blood products obtained by local donor pools have only a small risk of infection. Because non-hemophiliac polytransfused patients had HTLV III antibodies, there must be asymptomatic virus carriers in the local donor pool. The HTLV III antibody screening of all donors and the heat treating of factor concentrates will give better therapeutic safety.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732634
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  • 4
    Electronic Resource
    Electronic Resource
    Methoden zur Untersuchung der Proteinfraktionen im Urin (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 1056-1058 
    Details
    ISSN: 1432-1440
    Keywords: Urinary proteins ; Methods of urinary concentration ; Urinproteine ; Urinkonzentrationsverfahren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Untersuchung von Proteinurien ist die Konzentrierung des Urins erforderlich. Uns hat sich hierbei die Ultrafiltration (Druck) mit nachfolgender Dialyse und Lyophilisation bewährt. Im Normalurin fanden wir eine Gesamteiweißkonzentration von 59,6 (18,5–100,6) mg/24 Std. Die Proteineinzelfraktionen wurden durch Immundiffusion bestimmt. Wie die Wiederfindversuche mit verdünntem Normalserum zeigten, ergab unsere Methode eine gute Reproduzierbarkeit (VK 4,4).
    Notes: Summary Investigation of proteinuria requires concentrated urine. Ultrafiltration (pressure) with subsequent dialysis and lyophilisation was proved to be the best method. In normal urine we found a total protein excretion of 59.6 (18.5–100.6) mg per 24 hours. Each protein fraction was determined by immunodiffusion. The recovery of our method using diluted normal serum was excellent (variation coefficient 4.4).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01486767
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  • 5
    Electronic Resource
    Electronic Resource
    Reversible Keimzelltoxizität nach aggressiver Chemotherapie bei Patienten mit Hodentumoren: Ergebnisse einer prospektiven Studie (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 367-378 
    Details
    ISSN: 1432-1440
    Keywords: Germ cell tumors ; Gonadal toxicity ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The impact of aggressive chemotherapy on reproductive and endocrine gonadal function was prospectively studied in 44 patients with germ cell tumors. Diagnostic procedures to determine gonadal toxicity consisted of hormone determinations, semen analyses, interviews with a standardized questionnaire, and gonadal histology. After chemotherapy all patients showed elevated serum levels of follicle-stimulating hormone (FSH) and azoospermia due to germ cell and stem cell loss. Recovery of spermatogenesis, as indicated by normalization of serum FSH levels and sperm density, occurred in 77% of the patients 25–60 months after cessation of chemotherapy. In all patients serum testosterone and luteinizing hormone (LH) values remained within normal limits after therapy indicating resistance of Leydig cells to cytotoxic drugs. Three patients fathered four healthy children after completion of chemotherapy. These data suggest significant reproductive dysfunction in all men treated for germ cell tumors. However, most patients showed late and complete recovery of spermatogenesis. In contrast, endocrine gonadal function was unaffected after chemotherapy in all patients. FSH and LH are feasible markers to assess drug-induced gonadal toxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711264
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of recombinant interferon (IFN) alpha (α) and gamma (α) on the pituitary adrenocortical system in man
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 133 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(87)91491-9
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  • 7
    Electronic Resource
    Electronic Resource
    Too much chemotherapy in metastatic breast cancer (MBC)?
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 178 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(87)91619-0
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  • 8
    Electronic Resource
    Electronic Resource
    Combination therapy of low dose alfa-interferon and medroxyprogesterone acetate in metastatic renal cell cancer. A randomized multicenter trial
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 179 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(87)91620-7
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  • 9
    Electronic Resource
    Electronic Resource
    Können Standards die internistische Therapie für den Patienten transparenter machen? (1998)
    Springer
    Der Onkologe 4 (1998), S. 436-439 
    Details
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Die Transparenz medizinischer Entscheidungen gewinnt aus der Sicht aller am Gesundheitssystem Beteiligten zunehmende Bedeutung. Die Kosten-träger benötigen ebenso wie die Leistungserbringer spezifische Daten. Neuere Untersuchungen haben gezeigt, daß auch die Patienten bei Therapie entscheidungen involviert werden möchten, auch wenn letztlich die Verantwortung der Entscheidung beim Arzt verbleibt [6]. Seit einigen Jahren wurde in allen Bereichen der Medizin die systematische Entwicklung von Standards, im deutschen Sprachgebrauch besser Leitlinien [2] gefördert. Der Anstoß zu dieser Entwicklung ergab sich aus der zunehmend spürbaren Knappheit der Mittel. Neben dieser wirtschaftlichen Begründung für die Notwendigkeit von Leitlinien gibt es verschiedene, z. B. medizinische, ethische und juristische Gründe. Im nachfolgenden Aufsatz stellen wir uns die Frage, ob Leitlinien geeignet sind, die internistische Therapie für den Patienten transparenter zu machen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007610050223
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  • 10
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and biological activity in subcutaneous long-term administration of recombinant interferon-γ in cancer patients (1991)
    Springer
    Cancer immunology immunotherapy 34 (1991), S. 169-174 
    Details
    ISSN: 1432-0851
    Keywords: Recombinant interferon-γ ; Pharmacokinetics ; Metastases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have investigated the pharmacokinetics, tolerance, and biological activity of recombinant human interferon-γ (rHuIFNγ) administered subcutaneously to cancer patients. Twenty-one patients with lymphoma and metastatic cancer received rHuIFNγ (in doses of 0.1, 0.25, or 0.5 mg/m2) in two or three injections per week for up to 180 days. The most common adverse effects encountered were flu-like symptoms, fever and fatigue. The increase in body temperature after each administration ranged from 0 to 4°C depending on the individual patient, but was unrelated to the rHuIFNγ dose or its plasma concentration. The pharmacokinetic response of the patients after the two treatments showed a low intra-individual variability with respect to the plasma concentration/time profiles. However, as observed for the fever side-effect, the interindividual variation (CV 〉50%) was high for the parameters area under the data points (AUC0-t ) and maximum plasma concentration (c max). Despite this high interindividual variability, the mean values obtained for AUC0-t andc max after s.c. injection of rHuIFNγ were approximately proportional to the dose administered: the injection of 0.1, 0.25 or 0.5 mg/m2 rHuIFNγ resulted in AUC0-t values of 15.4, 31.5 or 69.6 ng h/ml, respectively andc max was found to be 1.0, 2.4 and 4.9 ng/ml, respectively. With this s.c. administration protocol, objective antitumour responses were observed in two patients, but there was no partial or complete remission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01742308
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