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  • 1
    Electronic Resource
    Electronic Resource
    Urinary enzyme analysis in renal allograft transplantation
    Amsterdam : Elsevier
    Clinica Chimica Acta 160 (1986), S. 137-144 
    Details
    ISSN: 0009-8981
    Keywords: Fructose-1, 6-bisphosphatase ; Glutathione S-transferase ; N-acetyl-β-D-Glucosaminidase ; Pyruvate kinase ; Urinary enzymes ; renal transplantation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(86)90134-8
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  • 2
    Electronic Resource
    Electronic Resource
    Combination therapy of low dose alfa-interferon and medroxyprogesterone acetate in metastatic renal cell cancer. A randomized multicenter trial
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 179 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(87)91620-7
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  • 3
    Electronic Resource
    Electronic Resource
    Treatment of advanced renal cell cancer with recombinant interferon alpha as a single agent and in combination with medroxyprogesterone acetate (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 95-100 
    Details
    ISSN: 1432-1335
    Keywords: Interferon plus MPA ; Advanced renal cell cancer ; Medroxyprogesterone acetate (MPA)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The response rates in metastatic renal cell cancer (RCC) after chemotherapy, hormonal treatment, or immunotherapy rarely exceed 15%. Recently, interferon alpha (IFNα) was used for treatment of this disease in several studies which also demonstrated response rates of 15%. In order to test whether IFN therapy combined with hormones would result in higher response rates we compared single agent IFN therapy with a combined therapy of rIFNα 2C plus medroxyprogesterone acetate (MPA) in a randomized multicenter trial. The rIFNα 2C (2MU) was given s.c. 5 times per week for 8–12 weeks and subsequently once weekly until week 48. In the combined treatment, 750 mg MPA was given p. o. daily until week 48 in addition to the IFN as described. The overall response rate in 93 evaluable patients was 5.4%, corresponding to 2 complete and 3 partial responses. Median survival was 7 months in both treatment groups. These data confirm the ineffectivity of low IFN doses for treatment of RCC. The low response rate is not increased by addition of MPA to IFN. The analysis of other IFN studies suggests that not only IFN doses but also IFN sources may influence response rates in metastatic RCC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390492
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  • 4
    Electronic Resource
    Electronic Resource
    Bilateral breast tumours in acute lymphatic leukemia (1990)
    Springer
    Archives of gynecology and obstetrics 247 (1990), S. 43-45 
    Details
    ISSN: 1432-0711
    Keywords: Acute lymphatic leukemia ; Breast tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report on a patient with acute lymphatic leukemia, who developed bilateral mammary deposits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02390654
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  • 5
    Electronic Resource
    Electronic Resource
    Acute phase response after myocardial infarction: Correlation between serum levels of cytokines and C-reactive protein (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 1083-1083 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01649312
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of active immunization to luteinizing-hormone-releasing hormone on the fertility and histoarchitecture of the reproductive organs of male rat (1992)
    Springer
    Urological research 20 (1992), S. 323-334 
    Details
    ISSN: 1434-0879
    Keywords: Anti-LHRH vaccination ; Histology ; Reproductive organs ; Male rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The feasibility of using a vaccine against luteinizing-hormone-releasing factor for supression of pituitary and gonadal functions has been indicated for some time. Antibody production against this low-molecular-weight, naturally occurring decapeptide, however, requires to be coupled to a carrier protein to enhance its immunogenicity. LHRH was coupled to diphtheria toxoid (DT). Adult male Sprague-Dawley rats with a mean basal body weight of 200g were immunized with anti-LHRH-DT (20 μg/injection/rat) at four-week intervals. An equal number of unexposed animals served as controls. Six animals were killed every two weeks up the end of the week 43. The vaccination schedule did not have any effect on the gain in body weight, nor was any adverse effect of vaccination observed in the course of the investigations. The pituitary, prostate, epididymis, testes, seminal vesicles, adrenal and thyroid were excised for determination of organ weight and histological examination. The adrenal, pituitary and thyroid showed no remarkable weight changes during the observation period, whereas the weights of the reproductive organs demonstrated significant reductions compared to those of the control group. The histopathology revealed marked to significant changes in the gonads and the accessory sex organs including the prostate. A progressive phase of regeneration of spermatogenesis was evident 98 days after vaccination. Total recovery of spermatogenesis was observed 300 days after vaccination. The mating studies showed the return of fertility 300 days after vaccination. The litters borne were normal. Prostate showed recovery after 154 days of vaccination. Our observations lend strong support to the hypothesis that anti-LHRH vaccine can be effectively used on the management of prostate carcinoma. If the vaccination is given together with a suitable dose of long-acting androgen, contained in an adequate delivery system, the regimen may be used for the regulation of male fertility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00922744
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of a potent LHRH-agonist on the pituitary gonadal axis with and without testosterone substitution (1986)
    Springer
    Urological research 14 (1986), S. 261-264 
    Details
    ISSN: 1434-0879
    Keywords: LHRH agonist ; Effect on pituitary-gonadal axis ; Different application regimen ; With and without testosterone substitution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this study we investigated the effect of low and high dosages of a potent LHRH agonist on the pituitarygonadal axis with special consideration to the effect on the tubular compartment of the testis. Included were 3 treatment groups: the probands in Group I were treated with 3 x 50μg HOE 766/week intranasally for 5 months; in Group II with 3 x 100 μg HOE 766 intranasally/day for 6 months and in Group III with 3x200μg HOE 766 intranasally plus 5mg fluoxymesterone orally/day for 5 months. With the low dose (Group I) no changes in the seminal parameters measured could be observed whereas LH and FSH levels increased in plasma, testosterone showed no change compared to preatreatment values. When high dosages/day of a potent LHRH agonist were administered without androgen replacement (Group II) pronounced decrease of LH and FSH took place, the testosterone plasma levels approached the female range. Spermatogenesis was arrested. The agonist plus androgen replacement (Group III) counteracted the suppression of spermatogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256570
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  • 8
    Electronic Resource
    Electronic Resource
    Circulating immune markers in advanced renal cell carcinoma during immunotherapy with interferon gamma (1996)
    Springer
    Urological research 24 (1996), S. 101-106 
    Details
    ISSN: 1434-0879
    Keywords: Renal cell carcinoma ; Circulating immune markers ; Immunotherapy ; Interferon gamma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Circulating immune markers sICAM-1, sELAM-1, sMHC-I, β2-MG, sCD4 and sCD8 were evaluated prior to and during immunotherapy with biologically active doses of interferon gamma (IFN-γ) in 16 patients with advanced renal cell carcinoma (RCC) over a period of 12 months. Compared to 20 healthy controls, significantly (P 〈 0.01) elevated baseline levels of circulating adhesion molecules sICAM-1 (mean 1166 vs 230 ng/ml) and sELAM-1 (70 vs 17 ng/ml) were found in all patients. Compared to responders (n = 2) or patients with stable disease (n = 2), progressive disease during therapy (n = 12) was associa ed with significantly (P 〈 0.05) higher mean concentrations of sICAM-1 (1574 vs 962 ng/ml) and sELAM-1 (86 vs 46 ng/ml). Pretherapeutic and intratherapeutic levels of sMHC-I among the RCC patients were significantly (P 〈 0.05) lower than among the controls (0.41 vs 0.8 ng/ml). sCD4 levels clearly showed the same tendency (24 vs 33 U/l). sCD8 baseline levels, by contrast, were significantly (P 〈 0.05) elevated (564 vs 336 U/l), reflecting either activation of the NK-cell subset or increased synthesis of CD8 + T-suppressor cells. Again, significantly (P 〈 0.05) higher intratherapeutic sCD8 concentrations were observable with progressive disease than with response to therapy or stable disease (721 vs 355 U/l). Interestingly, although the biologically active dose of IFN-γ was defined by an increase in β2-MG release of at least 30% within 48 h after injection, none of the other markers showed any significant alteration following IFN-γ administration, suggesting that IFN-γ in vivo does not produce changes in circulating markers of activation that might be expected on the basis of its effects in vitro. The finding of significantly elevated concentrations of sICAM-1, sELAM-1 and sCD8 in the presence of low sCD4 and sMHC-I levels might be of clinical significance for indicating ongoing tumor progression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431087
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  • 9
    Electronic Resource
    Electronic Resource
    321. Die kombinierte Herz-Lungen-Transplantation (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 936-936 
    Details
    ISSN: 1435-2451
    Keywords: Heart-lung transplantation ; CMV status ; Results ; Herz-Lungen-Transplantation ; CMV-Status ; Ergebnisse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Über erste eigene Erfahrungen mit der kombinierten Herz-Lungen-Transplantation wird berichtet. Wabenlunge, excessive pulmonale Hypertension bei offenem Ductus Botalli und Eisenmenger-Syndrom waren die Indikation bei unseren Patienten. Obwohl alle drei Patienten voroperiert waren und somit ein besonders hohes Risiko darstellten, haben alle den Eingriff überlebt. Die Immunsuppression bestand aus Cyclosporin, Azathioprin und ATG, das nach zwei Wochen durch Prednisolon ersetzt wurde. Alle drei Empfänger waren präoperativ Cytomegalovirus- (CMV) negativ, jedoch zwei der drei Spender positiv. Trotz Prophylaxe mit CMV-Hyperimmunoglobulin entwickelten die Empfänger dieser CMV-positiven Organe eine schwere interstitielle Pneumonie, der unser erster Patient 15 Monate nach der Transplantation erlag. Die dritte Patientin ist mit normaler Transplantatfunktion völlig rehabilitiert.
    Notes: Summary We report our initial experience with combined heart-lung transplantation in three patients. They suffered from honeycomb lung, pulmonary hypertension after open Botallo's duct and Eisenmenger syndrome. Since all three patients underwent thoracic surgery prior to transplantation, they represented a high risk group. However, all survived the procedure. Immunosuppression consisted of cyclosporin, azathioprin and ATG, which was replaced by steroids after 2 weeks. All recipients were CMV-negative before grafting, but two donors were CMV-positive. Despite active immunization with CMV-hyperimmunoglobulin, both developed interstitional pneumonia, which led to death after 15 months in our first patient and required specific therapy in the other. The remaining patient enjoys normal graft function and is fully rehabilitated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298106
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  • 10
    Electronic Resource
    Electronic Resource
    Alpha-interferon induces remission in hairy cell leukemia without enhancement of natural killing (1986)
    Springer
    Annals of hematology 52 (1986), S. 273-279 
    Details
    ISSN: 1432-0584
    Keywords: Natural killing ; Hairy cell leukemia ; Interferon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The number of large granular lymphocytes (LGL) and the capacity of peripheral blood mononuclear cells (PBMC) to lyse K 562 target cells in a natural killer (NK)-like fashion was evaluated in seven hairy cell leukemia (HCL) patients undergoing treatment with recombinant interferon-alpha-2 (rIFN-alpha-2). In HCL patients, whose peripheral blood showed high numbers (≧15×103/μl) of leukemic cells the number of LGL and their capacity to lyse K 562 tumor target cells were very low prior to treatment but increased significantly (p〈0.05) following interferon (IFN) therapy. In patients with low numbers of hairy cells (HC) in their peripheral blood, both these parameters were higher and remained largely unaffected throughout IFN treatment. In vitro, HC proved to be completely insensitive to natural killing when tested against unstimulated and IFN-activated LGL from healthy donors. These results fail to support the concept of IFN-mediated enhancement of host antitumor actions, responsible for the favourable clinical results in HCL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320790
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