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  • 1
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Schilddrüse ; Dünndarm ; Leiomyosarkom ; unbekannter Primärtumor ; Key words Thyroid gland ; Small intestine ; Leiomyosarcoma ; Unknown primary tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In a 69-year-old female patient a moderately pleomorphic spindle-cell thyroid tumour measuring 5 cm in diameter was initially misinterpreted as primary anaplastic thyroid carcinoma. During clinical investigations to elucidate the cause of severe anaemia, 17 months later an ulcerated duodenal leiomyosarcoma was detected and removed by duodenopancreatectomy. Reevaluation of the thyroid nodule led to revision of the initial diagnosis to metastatic leiomyosarcoma. Six months later the patient died from cerebral stroke. Autopsy findings confirmed the diagnosis of primary leiomyosarcoma of the duodenum with initial manifestation as thyroid metastasis.
    Notes: Zusammenfassung Bei einer 69 jährigen Patientin wurde ein 5 cm großer, mäßig pleomorpher spindelzelliger Schilddrüsentumor zunächst als primäres anaplastisches Schilddrüsenkarzinom verkannt. Erst im Rahmen einer 17 Monate später durchgeführten Anämieabklärung wurde ein 7 cm durchmessendes duodenales Leiomyosarkom entdeckt und mittels Duodenopankreatektomie reseziert. Die erneute Beurteilung der Primärhistologie führte zur Revision der initialen Diagnose und zur Einstufung des Schilddrüsentumors als metastatisches Leiomyosarkom. Die Patientin verstarb weitere 6 Monate später an einem apoplektischen Insult. Die Autopsiebefunde bestätigten die Einschätzung des Tumorleidens als ein initial durch die Schilddrüsenmetastase manifest gewordenes intestinales Sarkom.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 58 (1988), S. 233-238 
    ISSN: 1439-6327
    Keywords: Lymphocytes ; Neutrophil leukocytes ; Thrombocytes ; Splenectomy ; Beta-blockade ; Propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary During voluntary hyperventilation an increase in the lymphocyte and thrombocyte counts occurs, paralleled by an increase in plasma epinephrine and norepinephrine. All these changes are rapidly reversible after hyperventilation and are followed by an increase in the neutrophil granulocyte count. The pathophysiological mechanisms of these changes were investigated by comparison of the hyperventilation-induced changes of the blood picture in 11 normal, 9 splenectomized and 12 β-blocked volunteers. Splenectomy did not affect the hyperventilation-induced mobilization of lymphocytes and neutrophils but totally suppressed the change in the thrombocyte count, β-blockade by 80 mg propranolol did not suppress the hyperventilation-induced increase in neutrophils. It reduced the absolute increase of lymphocytes and thrombocytes by half, but it also increased the baseline counts of these cells. The study shows that hyperventilation mobilizes thrombocytes from the spleen but not from extralienal pools, and that lymphocytes and neutrophils are mobilized from extralienal pools. Whereas neutrophil mobilization is not suppressed by β-blockade, the reduction of hyperventilation-induced mobilization of lymphocytes and thrombocytes may be due to a reduction in the size of the mobilizable cell pools, and therefore cannot be interpreted as a sure indication that adrenergic mechanisms are involved in their hyperventilation-induced mobilization.
    Type of Medium: Electronic Resource
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