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  • Chemistry  (35)
  • Biochemistry and Biotechnology  (3)
  • Cadmium  (3)
  • Myoelectric  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 11 (1983), S. 285-290 
    ISSN: 1434-0879
    Keywords: Trace metals ; Cadmium ; Kidney cortex ; Ischaemic heart disease ; Medulla
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The trace element content of kidneys has been documented in very few international centres. Significant differences can be demonstrated between the cortical and medullary levels of calcium, zinc and cadmium. For the West of Scotland the values for the latter are similar to those found in Scandinavia. There are significantly higher cadmium contents in subjects who smoke and who have evidence of ischaemic heart disease.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 7 (1979), S. 285-289 
    ISSN: 1434-0879
    Keywords: Cadmium ; Iron ; Bendrofluazide ; Hypercalciuria Hyperzincuria ; Treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cadmium induces a variety of effects on kidney tubules including hypercalciuria. This is accompanied by hyperzincuria. The present work shows that both of these biochemical abnormalities can be corrected but where a state of cadmium-induced-anaemia exists urine zinc and calcium excretion do not follow the expected parallel course in response to iron therapy as they do with bendrofluazide.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 5 (1977), S. 15-20 
    ISSN: 1434-0879
    Keywords: Cadmium ; Kidney ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cadmium injection in rats affects the genito-urinary system. The renal effects are generally considered to be mainly tubular. Light microscopy of 29 specimens confirms cellular damage in the glomeruli with changes in glomerular capillaries. Electron microscopic changes in the glomeruli confirm changes in the podocytes, thickening of the basement lamina, the occurrence of electron dense deposits in association with the capillary endothelium with platelet and polymorphonuclear cell accumulations which suggests opening of the endothelial junction of the glomerular vessels.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0887-3585
    Keywords: interleukin-4 ; circular dichroism spectroscopy ; site-directed mutagenesis ; protein structure modeling ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The structure of human interleukin 4 (IL-4) was predicted utilizing a series of experimental and theoretical techniques. Circular Dichroism (CD) spectroscopy indicated that IL-4 belonged to the all α-helix class of protein structures. Secondary structure prediction, site-directed mutagenesis, and CD spectroscopy suggested a predominantly α-helical structure, consistent with a four-helix bundle structural motif. A human/mouse IL-4 chimera was constructed to qualitatively evaluate alternative secondary structure predictions. The four predicted helices were assembled into tertiary structures using established algorithms. The mapping of three disulfide bridges in IL-4 provided additional constraints on possible tertiary structures. Using accessible surface contact area as a criterion, the most suitable structures were right handed all antiparallel four-helix bundles with two overhand loop connections. Successful loop closure and incorporation of the three disulfide constraints were possible while maintaining the expected shape, solvent accessibility, and steric interactions between loops and helices. Lastly, energy minimization was used to regularize the chain.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 20 (1982), S. 251-252 
    ISSN: 1741-0444
    Keywords: Batteries ; Myoelectric ; Prothesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 28 (1990), S. 225-231 
    ISSN: 1741-0444
    Keywords: Motor unit firing ; Motor unit recruitment ; Myoelectric ; Signal-to-noise ratio
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract An important measure of the performance of a myoelectric control channel for powered artificial limbs is the myoelectric signal processor output signal-to-noise ratio (SNR). The signal and noise in this context are, respectively, the mean and variance of the estimate of some signal parameter to be used for control purposes. These quantities are determined by the signal processor, motor unit recruitment and motor unit firing statistics. The paper investigates, through analytical, simulation and experimental work, the role and significance of recruitment and firing statistics in channel performance. Equations are derived which express, for the single and multi-unit cases, channel SNR as a function of the number of active units, firing rates, action potential amplitude variation and action potential moments. A computer-simulated myoelectric signal is generated in which these variables can be controlled and SNR measured. The simulation results are compared with the theoretical and found to agree very well. Limited experiments with wire intramuscular electrodes and surface electrodes are performed to measurein vivo SNR from the biceps brachii muscle. The results of the experiments agree well with those of the simulation and theoretical work. The significance of this work is that it provides insight into the roles of important physiological parameters in myoelectric channel performance. It will also provide data necessary for the development of SNR enhancement techniques.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 29 (1991), S. 84-88 
    ISSN: 1741-0444
    Keywords: Control ; Interference ; Myoelectric ; Performance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Myoelectric signal is an important source of control information for powered prostheses. A commonly used performance measure for the signal processors of such control systems is the ratio of processor output mean to variance. This ratio (SNR) is a function of a number of factors including physiological parameters and additive interference. The paper investigates the effects of motor unit physiological parameters and interference on control performance, with particular reference to SNR. Performance equations are derived and verified within vivo experiments. The results show a complex interaction among the physiological parameters and interference. A particular point of interest is the misleading SNR values that can occur under certain recruitment and interference conditions.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 6 (1994), S. 615-622 
    ISSN: 0899-0042
    Keywords: absolute configuration ; chiral stationary phase ; enantiomer ; chiral recognition ; NSAID ; HPLC ; NMR ; CD ; X-ray ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Assignment of absolute configuration to a recently developed chiral selector useful in the separation of the underivatized enantiomers of naproxen and other nonsteroidal anti-inflammatory drugs (NSAIDs) is described. Circular dichroism, 1H NMR, and X-ray diffraction have been used to confirm the original assignment which was based solely upon elution orders from HPLC chiral stationary phases. All of these techniques agree in the assignment of the (S,S) absolute configuration to the enantiomer of the chiral selector which associates preferentially with (S)-naproxen. © 1994 Wiley-Liss, Inc.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 3 (1991), S. 188-195 
    ISSN: 0899-0042
    Keywords: fast analysis times ; enantiomers ; chiral stationary phase ; Pirkle-concept ; achiral derivatization ; rapid screening ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A Pirkle-concept chiral stationary phase (CSP) derived from N-(1-naphthyl)leucine was evaluated for developing methods to reduce analysis times and investigating techniques in the rapid screening of a variety of chiral compounds over a given chiral selector. The effects of reduced column lengths and elevated temperatures were studied to shorten analysis times.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 7 (1984), S. 382-388 
    ISSN: 0935-6304
    Keywords: Gas chromatography ; Capillary columns ; HETP equation ; Optimum column parameters ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An HETP equation for the capillary column is developed that takes into account the dependence of gaseous diffusion on pressure, the compressibility of the mobile phase, together with the unique relationship between mobile phase velocity, and the resistance to mass transfer in the stationary phase. The equation is used to develop a procedure for column optimization and expressions are derived that allow the optimum column radius and optimum column length to be calculated for a given fixed inlet pressure. It is shown that fast, simple separations are optimally achieved using relatively short small diameter columns. Conversely, optimum performance for the separation of complex mixtures requiring higher efficiencies requires the use of long columns with relatively large diameters.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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