ISSN:
1433-8580
Keywords:
Acute hepatic failure
;
Insulin
;
Glucagon
;
Glucagon-like peptides
;
Blood-brain barrier
;
Thalamus-hypothalamus
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Insulin contents in the thalamus-hypothalamus were significantly increased in acute hepatic failure dogs treated with dimethylnitrosamine. Glucagon immunoreactivity (GI) contents also tended to increase in the same portion of the brain. However, insulin and GI contents in the cerebral cortex and midbrain did not rise. Glucagon-like immunoreactivity (GLI) contents were much higher than GI in all the brain regions tested, but the levels were not significantly altered in hepatic failure dogs. A simultaneous infusion of insulin and glucagon to hepatic failure dogs failed to produce an elevation of insulin, GI and GLI contents even in the thalamus-hypothalamus.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01852045
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