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  • Cerebral ischaemia  (2)
  • Immunohistochemistry  (2)
  • Boron  (1)
  • Capillary supply  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Properties of boron coatings used as plasma facing material of fusion device
    Amsterdam : Elsevier
    Thin Solid Films 253 (1994), S. 518-521 
    Details
    ISSN: 0040-6090
    Keywords: Boron ; Glow discharge ; Oxidation ; Plasma processing and deposition
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0040-6090(94)90377-8
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Alterations of local cerebral blood flow, phorbol 12,13-dibutyrate binding activity, and histological damage during acute focal ischaemia in rat brain (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 1118-1125 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral ischaemia ; local cerebral blood flow ; ischaemic damage ; PDBu binding activity ; duration of middle cerebral artery occlusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The alterations of the local cerebral blood flow (LCBF),3 H-phorbol 12,13-dibutyrate (PDBu) binding activity were measured, and histological findings were also examined during the closed time course (0, 1, 3, 5, 7 hour) after middle cerebral artery occlusion (MCAO) in rat brain to assess the complex pathophysiology of acute focal ischaemia. From 1 to 3 hours after the start of MCAO, significant (p 〈 0.01) hyperreactivity of the second messenger system involving PDBu binding may be present, despite low perfusion of LCBF, and severe damage in the striatum whereas sparing almost completely the cortex on histological examination. At 5 hours, the PDBu binding activity increased slightly but not significantly but is reduced markedly at 7 hours after MCAO compared with the control group. The measurement of PDBu binding activity, additionally to measuring the LCBF and observation of the histological change might be a useful indicator in determining the threshold and duration of ischaemia which cause functionally irreversible cell damage in the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01412317
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  • 3
    Electronic Resource
    Electronic Resource
    Calcineurin in human brain and its relation to extrapyramidal system (1986)
    Springer
    Acta neuropathologica 72 (1986), S. 150-156 
    Details
    ISSN: 1432-0533
    Keywords: Calcineurin ; Huntigton's disease ; Human brain ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Calcineurin immunoreactivity has been successfully detected in formalin-fixed paraffinembedded postmortem human brain tissue using the peroxidase-antiperoxidase method. We have examined two autopsy cases with Huntigton's disease (HD), three cases with Parkinson's disease, and two senile patients as controls. In the controls, calcineurin immunoreactivity was present in neuronal cells only and highly concentrated in the caudate nucleus, putamen, globus pallidus (striato-pallidal pathway), substantia nigra (striato-nigral pathway) and hippocampal formation. These localizations were similar to those identified in rat brain. There was a marked depletion of neurons containing calcineurin in the caudate nucleus and putamen, and a marked reduction of calcineurin-immunoreactive nerve fibers in the globus pallidus and substantia nigra were found in the cases with HD, but not in those with Parkinson's disease. These findings suggest that calcineurin can be a useful and specific index of neuronal degeneration in the caudato-putamen resulting from extrapyramidal diesease, and that the calcineurin-immunostaining method can be a valuable tool for clarifying the anatomy of the human extrapyramidal system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685977
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  • 4
    Electronic Resource
    Electronic Resource
    Cytochrome oxidase activity during acute focal ischaemia in rat brain (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 1126-1131 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral ischaemia ; ischaemic brain damage ; cytochrome oxidase ; middle cerebral artery occlusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An enzyme-histochemical technique was used to examine the changes in cytochrome oxidase activity during acute focal ischaemia in the rat. In the somatosensory cortex, the enzyme activity began to increase significantly (p 〈 0.01) 1 hour after middle cerebral artery occlusion (MCAO) and continued to increase up to 3 hours, during which ischaemic cell damage was not detected. In the striatum, the enzyme activity increased significantly (p 〈 0.01) 1 hour after MCAO in the absence of morphological evidence of ischaemic cell damage; a peak activity was reached at 2 hours, and began to decline 3 hours after MCAO when moderate ischaemic change was detected. In both cortical and subcortical areas, the enzyme activity tended to decrease from 4 hours after MCAO, and was reduced to a level similar to or below that of the non-ischaemic hemisphere 5 hours after MCAO, when severe ischaemic damage was demonstrated. The relation of this transient increase of cytochrome oxidase activity in the early stage of acute ischaemia and the hypermetabolism of neuronal cells during ischaemic insult was discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01412318
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  • 5
    Electronic Resource
    Electronic Resource
    A comparative immunohistochemical study of calcineurin and S-100 protein in mammalian and avian brains (1988)
    Springer
    Experimental brain research 69 (1988), S. 645-650 
    Details
    ISSN: 1432-1106
    Keywords: S-100 protein ; Calcineurin ; Mammalian brain ; Avian brain ; Vertebrate brain ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The cellular and topographic localization of calcineurin and S-100 protein was examined immunohistochemically in the mammalian and avian brain. Calcineurin immunoreactivity in both the avian and mammalian brain was located only in neuronal cells. S-100 protein was localized mainly in the glial and Schwann cells within the mammalian brain. However, in the avian brain, neuronal cells in certain regions such as the paleostriatum primitivum and the cerebellum, as well as other non-neuronal cells, exhibited S-100 protein immunoreactivity. A distinct difference was demonstrated in the macroscopic topographic distribution patterns of S-100 protein immunoreactivity between the mammalian and avian brains, while the patterns of calcineurin distribution were essentially identical. In addition, we provided calcineurin- and S-100 protein-immunocytochemical results for the turtle, frog and fish brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00247316
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  • 6
    Electronic Resource
    Electronic Resource
    The relationship of voluntary running to fibre type composition, fibre area and capillary supply in rat soleus and plantaris muscles (1991)
    Springer
    European journal of applied physiology 62 (1991), S. 211-215 
    Details
    ISSN: 1439-6327
    Keywords: Voluntary running ; Soleus muscle ; Plantaris muscle ; Fibre type composition ; Fibre area ; Capillary supply ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty 4-week-old Wistar rats exercised voluntarily in running wheels each day for 45 days. Fibre type composition, fibre cross-sectional area and the number of capillaries around a fibre of the slow-twitch soleus and fast-twitch plantaris muscles were examined and compared with animals which had no access to running wheels. The exercise group had a higher percentage of fast-twitch oxidative glycolytic (FOG) fibres and a lower percentage of fast-twitch glycolytic (FG) fibres in the deep portion of the plantaris muscle. The area of FOG fibres in the surface portion of the plantaris muscle was also greater in the exercise group. In the exercised animals, there was a positive relationship between the running distance and the area of FOG fibres in both the deep and surface portions of the plantaris muscle. In addition, the running distance correlated positively with the percentage of FOG fibres and negatively with that of FG fibres in the deep portion of the plantaris muscle. There were no relationships between the running distance and fibre type composition, or fibre area and capillary supply in the soleus muscle. These results suggested that the increase in the percentage and area of FOG fibres in the fast-twitch muscle was closely related to voluntary running.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00643744
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