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  • Immunoblotting  (2)
  • SchlĂŒsselwörter Obstruktives Schlafapnoesyndrom  (2)
  • Bundesrepublik Deutschland  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Pharyngolaryngoskopische Befunde bei Patienten mit obstruktivem Schlafapnoesyndrom und primÀrem Schnarchen (2000)
    Springer
    HNO 48 (2000), S. 917-921 
    Details
    ISSN: 1433-0458
    Keywords: SchlĂŒsselwörter Obstruktives Schlafapnoesyndrom ; Schlafmedizin ; Diagnostik ; Propofol ; Endoskopie ; Keywords Endoscopy ; Diagnostic use of propofol ; Sleep apnea syndrome ; Diagnosis ; Snoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background and objective. The localization of an upper airway collapse in snorers and patients suffering from obstructive sleep apnea was a subject frequently discussed in the last few years. Pharyngolaryngoscopy during sleep or drug-induced sleep allows evaluation of upper airway conditions. Patients/methods. A total of 324 patients suffering from snoring or obstructive sleep apnea underwent flexible pharyngolaryngoscopy while awake and under propofol-induced sedation in the course of routine diagnostic procedures in the sleeping lab. In this study, the results of pharyngolaryngoscopy are compared to results of the MĂŒller maneuver and polysomnographic recordings. The therapeutic consequences of this additional investigation are discussed. Results. In 95% of cases snoring was observed during drug-induced sleep. A significant discrepancy was seen between results of the endoscopy while being awake (MĂŒller maneuver) and during drug-induced sleep. The degree of collapse differed significantly in the area of the base of the tongue. Severe collapse was seen much more often with pharyngoscopy during drug-induced sleep compared to the results during the MĂŒller maneuver. Conclusions. The collapsibility in the area of the base of the tongue correlated with higher results in the RDI (respiratory disturbance index) registered with standard polysomnography. Snoring and upper airway collapse were easily surveyed, and the pharyngolaryngoscopy during propofol-induced sleep proved to be a simple, safe, readily controllable and effective supplementary diagnostic device for the diagnosis and treatment of obstructive sleep apnea and snoring.
    Notes: Zusammenfassung Hintergrund und Fragestellung. Die Vorhersage des Ortes der Obstruktion oder des Weichteilkollapses bei Patienten mit primĂ€rem Schnarchen und obstruktivem Schlafapnoesyndrom war in den letzten Jahren hĂ€ufig Thema von Untersuchungen. Die flexible Nasopharyngolaryngoskopie im Schlaf oder in Sedierung ist in diesem Zusammenhang eine bekannte Untersuchungsmethode, trotz ihrer nichtphysiologischen Basis. Patienten/Methodik. Die Ergebnisse von 324 Patienten, die neben der Routinediagnostik im Schlaflabor mittels einer flexiblen Pharyngolaryngoskopie im Wachzustand und in Propofol-Sedierung untersucht wurden, werden beschrieben. Hierbei werden Vergleiche zum MĂŒller-Manöver und zu den jeweiligen Polysomnographieergebnissen angestellt und die therapeutische Konsequenz dieser Zusatzdiagnostik diskutiert. Ergebnisse. In 95% der FĂ€lle konnte wĂ€hrend des medikamentös induzierten Schlafs Schnarchen registriert werden. Auf Höhe des Zungengrunds fand sich eine signifikant stĂ€rkere Kollapsneigung bei der Untersuchung im Propofol-Schlaf verglichen mit den Befunden des MĂŒller-Manövers. Die StĂ€rke des Zungengrundkollapses korrelierte mit dem in der Polysomnographie ermittelten RDI (respiratory disturbance index). Schlussfolgerungen. Insgesamt fand sich ein deutlicher Unterschied zwischen der AusprĂ€gung des Weichteilkollapses beim MĂŒller-Manöver und beim Propofol-Schlaf; Schnarchen und Kollapsneigung ließen sich zuverlĂ€ssig beobachten. Die Pharyngolaryngoskopie erwies sich als einfach und sicher durchfĂŒhrbare, komplikationsarme und aussagekrĂ€ftige Zusatzdiagnostik im Rahmen der AbklĂ€rung des primĂ€ren Schnarchens und des obstruktivem Schlafapnoesyndrom.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050688
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  • 2
    Electronic Resource
    Electronic Resource
    Morphologische und funktionelle VerÀnderungen der Nasenschleimhaut nach nCPAP-Therapie (2000)
    Springer
    HNO 48 (2000), S. 747-752 
    Details
    ISSN: 1433-0458
    Keywords: SchlĂŒsselwörter Obstruktives Schlafapnoesyndrom ; nCPAP Therapie ; Nasenschleimhaut ; Elektronenmikroskopie ; Keywords Obstructive sleep apnea ; nCPAP-therapy ; Nasal mucosa ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background and objective. The treatment success of nCPAP therapy (nasal continuous positive airway pressure) depends partly on the relief of symptoms and partly on long-term patient acceptance and the related avoidance of complications.Nasal complaints constitute the most frequently reported side effects and, together with problems of mask application, are among the primary factors causing an nCPAP-therapy to be prematurely discontinued. Patients/Methods. To assess the morphological changes of the nasal mucosa during nCPAP-therapy, we excised specimens of nasal mucosa tissue in twelve patients with obstructive sleep apnea syndrome (OSAS) both before and 3–10 months after establishing nCPAP-mask acceptance. The specimens were examined by electron microscopy. Results. In all these patients, acceptance of the CPAP mask marked the initial part of therapy. In addition, mucociliary clearance was assessed by the saccharin test before and after therapy. In all patients, the nasal epithelium underwent fundamental changes upon CPAP therapy, which became manifest as modifications in the shape of epithelial cells, conglutination and clumping of the microvilli, and the appearance of immunocompetent cells. Once patients were nCPAP mask compliant, mucociliary clearance was distinctly prolonged in all cases. Conclusions. A successful therapeutic concept should provide normalization of room temperature and air humidity once nCPAP mask compliance has been achieved, and include regular assessment of the condition of the mucosa in the upper respiratory tract. Only by these measures can nasal complications be countered or therapy be applied at an early stage.
    Notes: Zusammenfassung Hintergrund und Fragestellung. Der Therapieerfolg einer nCPAP-Therapie (“nasal continuous positive airway pressure”) ist einerseits abhĂ€ngig von der Linderung der Beschwerden und andererseits von der Langzeitakzeptanz und der hiermit verbundenen Vermeidung von Komplikationen. Nasale Beschwerden sind die hĂ€ufigsten Nebenwirkungen und neben den Maskenproblemen die wichtigste Ursache, weshalb eine nCPAP-Therapie frĂŒhzeitig unterbrochen wird. Patienten/Methodik. Wir haben bei 12 Patienten mit einem obstruktivem Schlafapnoesyndrom Probeexzisionen aus der Nasenschleimhaut vor und 3–10 Monate nach Anpasssung der nCPAP-Maske entnommen und elektronenmikroskopisch untersucht. Bei all diesen Patienten war die Anpassung der nCPAP-Maske die Ersttherapie. DarĂŒber hinaus wurde vor und nach der Therapie die mukoziliĂ€re Clearance mit Hilfe des Saccharintests beurteilt. Ergebnisse. Bei allen Patienten kam es nach der nCPAP-Therapie zur grundlegenden VerĂ€nderungen des Nasenepithels mit VerĂ€nderung der Epithelzellenform, Verklebungen und Verklumpungen der Mikrovilli und auftreten von immunkompetenten Zellen. In allen FĂ€llen war die mukoziliĂ€re Clearance nach Anpassung der nCPAP-Maske deutlich verlĂ€ngert. Schlussfolgerungen. Ein erfolgreiches Therapiekonzept sollte die Normalisierung der Raumtemperatur und Luftfeuchtigkeit gleich nach der Anpassung der nCPAP-Maske und die regelmĂ€ĂŸige Beurteilung der SchleimhautverhĂ€ltnisse der oberen Atemwege beinhalten. Nur somit können nasale Komplikationen aufgehalten oder frĂŒhzeitig therapiert werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050652
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Aufnahme trans-isomerer FettsĂ€uren — Eine AbschĂ€tzung auf Basis der Daten der nationalen Verzehrsstudie 1991 (1992)
    Springer
    European journal of nutrition 31 (1992), S. 196-204 
    Details
    ISSN: 1436-6215
    Keywords: trans-FettsÀuren ; Fettverzehr ; nationale Verzehrsstudie ; Bundesrepublik Deutschland ; trans fatty acids ; fat intake ; consumption assay ; Federal Republic of Germany
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary The intake of trans octadecenoic acids is estimated by a national consumption assay. The daily intake in West Germany differs between 3,4 g for women und 4,1 g for men. The consumption of trans fatty acids decreased in the last years, due to the progress in food technology and changes in nutritional habits. The main sources of trans fatty acids are partially hydrogenated vegetable fats just as well as ruminant and dairy fats.
    Notes: Zusammenfassung Die Aufnahme von trans-OctadecensĂ€uren in der Bundesrepublik Deutschland (alte BundeslĂ€nder) wird anhand der nationalen Verzehrsstudie abgeschĂ€tzt. Sie betrĂ€gt fĂŒr Frauen 3,4 g/Person und Tag und fĂŒr MĂ€nner 4,1 g/Person und Tag. Die Aufnahme ist in den letzten Jahren aufgrund verĂ€nderter Verzehrsgewohnheiten und verbesserter Technologien zurĂŒckgegangen. Hauptquellen der trans-FettsĂ€ureaufnahme sind neben den teilgehĂ€rteten Pflanzenfetten, das Fett und die Milch der WiederkĂ€uer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01611142
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  • 4
    Electronic Resource
    Electronic Resource
    CTAB electrophoresis and immunoblotting: a new method for the determination of soy protein in meat products (1997)
    Springer
    Zeitschrift fĂŒr Lebensmittel-Untersuchung und -Forschung 205 (1997), S. 224-226 
    Details
    ISSN: 1431-4630
    Keywords: Key words CTAB electrophoresis ; Immunoblotting ; Soy protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  A CTAB electrophoresis method that is able to separate soy protein on the basis of molecular mass is introduced. The cationic detergent CTAB (N-cetyl-N,N,N-trimethylammoniumbromide) is not as denaturing as sodium dodecyl sulphate (SDS), and thereby allows separation of proteins that are virtually unchanged from their naturally occurring state. After blotting on a nitrocellulose (NC) membrane, the protein can be detected by a soy-specific antibody. Soy protein isolates, concentrates and hydrolysates as well as meat products containing these soy protein products were separated by CTAB electrophoresis and blotted on NC membranes. As little as 0.5% soy protein in meat products could be detected, even if the meat product had been heated to 120°C for 30 min during the manufacturing process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002170050155
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  • 5
    Electronic Resource
    Electronic Resource
    Isolation and characterization of a major allergen in kiwi fruit (1997)
    Springer
    Zeitschrift fĂŒr Lebensmittel-Untersuchung und -Forschung 205 (1997), S. 364-369 
    Details
    ISSN: 1431-4630
    Keywords: Key words Food allergens ; Immunoblotting ; Ion-exchange chromatography ; Kiwi fruit ; N-terminal microsequencing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  The isolation of an important allergen in kiwi fruit (Actinidia chinensis) by ion-exchange chromatography (IEC) and micropreparative SDS-PAGE followed by electroelution is reported. The purity of the allergen was analysed by SDS-PAGE and immunoblotting with sera from patients who have an allergy to kiwi. The allergen was shown to have a molecular weight of 43 kDa by SDS-PAGE/immunoblotting and an isoelectric point of approximately 6.9 as estimated by IEC. In accordance with World Health Organization nomenclature, this allergen is called Act c 2. By immunoblot inhibition it was shown that epitopes from different allergens in kiwi fruit are also located on Act c 2. N-terminal amino acid sequencing of 17 amino acid residues did not reveal homology with the major allergens in birch pollen (Bet v 1), apple (Mal d 1) or with other proteins of allergenic plant foods. In addition, the isoelectric point of a 67-kDa allergen in kiwi fruit was estimated to be 7.4 by IEC, but micropreparative isolation of this allergen failed because of its very low content in the fruit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002170050182
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    Paper (German National Licenses)
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