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  • 1
    Electronic Resource
    Electronic Resource
    Postprandial oscillations of plasma glucose, insulin and C-peptide in man (1987)
    Springer
    Diabetologia 30 (1987), S. 769-773 
    Details
    ISSN: 1432-0428
    Keywords: Plasma glucose ; insulin ; C-peptide ; meals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Postprandial plasma glucose, insulin and C-peptide profiles were studied in eight normal subjects, in the afternoon or in the evening. Two to five synchronous oscillations, with a mean period of 51 to 112 min were detected. The oscillations were highest after meals and were then damped, reverting to fasting levels after up to 340 min. Additional short-term oscillations, with periods of 20–30 min and 9–14 min, were observed. Cross-correlation studies of glucose and insulin and of insulin and C-peptide revealed a high correlation in the frequency bands considered. The synchronous oscillations of insulin and C-peptide suggest cyclic variations in pancreatic secretion rather than cyclic changes in insulin degradation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00275742
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Alteration in the temporal organisation of insulin secretion in Type 2 (non-insulin-dependent) diabetic patients under continuous enteral nutrition (1991)
    Springer
    Diabetologia 34 (1991), S. 435-440 
    Details
    ISSN: 1432-0428
    Keywords: Glucose ; insulin ; C-peptide ; diabetic ; ultradian rhythm ; enteral nutrition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Concomitant oscillations of plasma glucose, insulin and C-peptide levels with a period of about 80 min between peak levels have been identified in normal man. To determine whether these oscillations persist in Type 2 (non-insulin-dependent) diabetic patients, peripheral plasma levels of glucose, insulin and C-peptide were measured at 10 min intervals over 12 h in six patients and in six matched control subjects during continuous enterai nutrition (90 kcal.h−1; 50% carbohydrate, 35% fat, 15% protein). The insulin secretion rate was estimated from peripheral C-peptide levels using an open two-compartment model. For the control subjects, mean plasma glucose, insulin and insulin secretion profiles rose sharply and then attained a steady-state; in contrast, for the diabetic patients, the mean insulin and insulin secretion profiles were characterized by a slow ascending trend throughout the day. Mean glucose levels rose sharply and reached higher levels than in the control subjects. The individual 12 h profiles revealed synchronous oscillations of plasma glucose, plasma insulin, and insulin secretion in the control subjects. In the diabetic patients, the number of plasma insulin and insulin secretion pulses was significantly lower; they had a smaller amplitude and were less frequently associated with the glucose pulses. However, plasma glucose levels had a similar oscillatory pattern in the diabetic patients compared with the control subjects, albeit with a higher absolute amplitude. The poor association between glucose and insulin secretion pulses in the diabetic patients suggests that insulin pulses are insufficient to account for the glucose pulses. Slowness in the dynamics of insulin secretion may explain the large initial rise in glucose in the diabetic patients under continuous enteral nutrition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403183
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Atrial natriuretic factor secretion: a role for atrial systolic ejection force? (1996)
    Springer
    European journal of applied physiology 72 (1996), S. 440-444 
    Details
    ISSN: 1439-6327
    Keywords: Atrial ejection force ; Atrial natriuretic factor ; Echographic parameters ; Heart transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The increase in plasma concentration of atrial natriuretic factor in heart transplant patients has not been fully elucidated. Besides an eventual pressure or volume overload leading to passive atrial distension, the atrial tension developed during atrial systole, or atrial ejection force, which may be increased by the transplantation procedure, is an important determinant of atrial natriuretic factor release. We therefore determined the plasma concentration of atrial natriuretic factor and the maximal atrial ejection force in 15 heart transplant patients and 8 controls, matched for age and body mass. Atrial ejection force, as defined as the force exerted by the left atrium to accelerate blood into the left ventricle during atrial systole, was obtained using combined two-dimensional imaging and doppler echocardiography. Serum creatinin concentrations, heart rate [91.9 (SD 13.2) vs 71.8 (SD 10.9) beats · min−1], mean arterial blood pressure [103.9 (SD 9.8) vs 87.4 (SD 5.8) mmHg, 13.85 (SD 1.31) vs 11.65 (SD 0.77) kPa], left ventricular posterior wall thickness and interventricular septum thickness were higher in heart transplant patients compared to controls. Plasma concentration of atrial natriuretic factor was also elevated in heart transplant patients [63.9 (SD 18.1) vs 34.0 (SD 3.2) pg · ml−1; P〈0.001]. In contrast, although the left atrial area was greater in heart transplant patients [28.2 (SD 4.8) vs 15.8 (SD 2.5) cm2; P〈0.001], mitral area, transmitral Doppler A-wave maximal velocity and atrial ejection force were similar in transplant and in control patients [7.7 (SD 3.5) vs 8.9 (SD 2.8) kdyn, 77 (SD 35) vs 89 (SD 28) mN]. No significant correlation was observed between concentration of atrial natriuretic factor and atrial ejection force, either in heart transplant patients or in controls. Thus, the elevated plasma concentration of atrial natriuretic factor observed in these heart transplant patients was multifactorial in origin, and was considered to depend upon an hypersecretion rather than upon a decreased clearance rate. Moreover, it is suggested that the atrial ejection force was unlikely to have participated in this enhanced release of atrial natriuretic factor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00242273
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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