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  • Inorganic Chemistry  (12)
  • Smooth muscle  (4)
  • Ca current  (2)
  • Ca^2^+ channel  (2)
  • Primary structure  (2)
  • 1
    Electronic Resource
    Electronic Resource
    The calmodulin fraction responsible for contraction in an intestinal smooth muscle
    Amsterdam : Elsevier
    FEBS Letters 170 (1984), S. 383-386 
    Details
    ISSN: 0014-5793
    Keywords: Calmodulin ; Contraction control ; Myosin light chain kinase ; Smooth muscle ; Taenia coli
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(84)81349-6
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  • 2
    Electronic Resource
    Electronic Resource
    The cDNA and deduced amino acid sequence of the γ subunit of the L-type calcium channel from rabbit skeletal muscle
    Amsterdam : Elsevier
    FEBS Letters 267 (1990), S. 153-156 
    Details
    ISSN: 0014-5793
    Keywords: Ca^2^+ channel ; Membrane protein ; Skeletal muscle ; cDNA cloning
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(90)80312-7
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  • 3
    Electronic Resource
    Electronic Resource
    Primary structure and functional expression of a high voltage activated calcium channel from rabbit lung
    Amsterdam : Elsevier
    FEBS Letters 269 (1990), S. 409-412 
    Details
    ISSN: 0014-5793
    Keywords: Ca^2^+ channel ; Expression ; Primary structure ; Smooth muscle
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(90)81205-3
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Primary structure and functional expression of a cyclic nucleotidegated channel from rabbit aorta
    Amsterdam : Elsevier
    FEBS Letters 329 (1993), S. 134-138 
    Details
    ISSN: 0014-5793
    Keywords: Aorta ; Cyclic nucleotidegated channel ; Expression ; Primary structure
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(93)80209-D
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  • 5
    Electronic Resource
    Electronic Resource
    The cDNA of the two isoforms of bovine cGMP-dependent protein kinase
    Amsterdam : Elsevier
    FEBS Letters 251 (1989), S. 191-196 
    Details
    ISSN: 0014-5793
    Keywords: Protein kinase, cyclic GMP-dependent ; Smooth muscle ; cDNA cloning
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(89)81453-X
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  • 6
    Electronic Resource
    Electronic Resource
    Modulation of Ca current during the phosphorylation cycle in the guinea pig heart (1986)
    Springer
    Pflügers Archiv 407 (1986), S. 123-128 
    Details
    ISSN: 1432-2013
    Keywords: Guinea pig heart ; Ca current ; Phosphorylation cycle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The calcium current (I Ca) in the heart is increased by phosphorylation of a protein which is part of, or close to, the Ca channel. The phosphorylation is catalysed by cAMP-dependent protein kinase (cAMP-PK). The question whether dephosphorylated channels are available to open on depolarization was examined in ventricular myocytes of guinea pig by recording whole cellI Ca during dialysis with either regulatory (R) subunit of cAMP-PK or protein kinase inhibitor (PKI) or adenosine-5′-(γ-thio)-triphosphate (ATPγS). The following results were obtained: 1) R subunit reduced and PKI reversed the isoprenaline (ISP)-induced enhancement ofI Ca, suggesting their ability to inhibit cAMP-PK. 2) R subunit and PKI, however, reduced basal (i.e. non β-adrenergically stimulated)I Ca only by about 20%. 3) Dialysis with ATPγS resulted in a slow increase in basalI Ca, presumably due to dephosphorylation-resistant thiophosphorylation. 4) When, however, the cell was dialyzed with PKI the effect of ATPγS was almost completely suppressed, suggesting no detectable phosphorylation related to the channel activity in this condition. These results support the view that even in the dephosphorylated state Ca channels are available to open on depolarization and that phosphorylation by cAMP-PK increases the opening probability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00580662
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  • 7
    Electronic Resource
    Electronic Resource
    Relaxation of skinned coronary arteries depends on the relative concentrations of Ca2+, calmodulin and active cAMP-dependent protein kinase (1985)
    Springer
    Pflügers Archiv 405 (1985), S. 70-76 
    Details
    ISSN: 1432-2013
    Keywords: Skinned coronary arteries ; Smooth muscle ; Regulation of contractile tone ; cAMP-dependent protein kinase ; cAMP-dependent modulation of contractile tone ; Calmodulin ; Calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Maximally contracted detergent skinned coronary smooth muscle fibres are relaxed by lowering the concentration of free Ca2+. The extent and rate of relaxation depends on the concentration of free Ca2+ and calmodulin (CaM) suggesting that it is the Ca2+. CaM complex which is responsible for maintaining tension. At a fixed concentration of Ca2+ and CaM further relaxation can be achieved by addition of the catalytic subunit of the cAMP-dependent protein kinase (cAMP-kinase). The extent as well as the relaxation rate depend on the concentration of cAMP-kinase (0.01–0.5 μM) and both are antagonized by high concentrations of Ca2+ and CaM. The Ca2+-requirement for obtaining half maximal concentration is shifted from 1.1 μM to 6.3 μM Ca2+ in the presence of 0.5 μM cAMP-kinase. These data indicate that the response of the contractile apparatus to a change in the free [Ca2+] can be modulated by cAMP-kinase at the level of the contractile proteins. It is further suggested that the tone of coronary smooth muscle is determined by the relative and not by the absolute concentrations of Ca2+, CaM and cAMP-kinase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00591100
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  • 8
    Electronic Resource
    Electronic Resource
    On the mechanism of β-adrenergic regulation of the Ca channel in the guinea-pig heart (1985)
    Springer
    Pflügers Archiv 405 (1985), S. 285-293 
    Details
    ISSN: 1432-2013
    Keywords: Cardiac myocytes ; Ca current ; Isoprenaline ; Cyclic AMP ; cAMP-Dependent protein kinase ; Protein phosphorylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dose-response relations for the increase in the amplitude of Ca current (I Ca) on external application of isoprenaline (ISP) and internally applied cyclic AMP (cAMP) or catalytic subunit of cAMP-dependent protein kinase (C subunit) were established in single ventricular cells of the guinea pig. An intracellular dialysis technique was used. The threshold concentration was for ISP 10−9 M, for cAMP 3 μM (pipette concentration to which 10−5 M 3-isobutyl-1-methylxanthine was added) and for C subunit around 0.4 μM (pipette concentration). The concentrations for the half-maximal effect were 3.7×10−8 M (ISP), 5.0 μM (cAMP) and 0.95 μM (C subunit) and for the maximum effect 10−6 M (ISP), 15–20 μM (cAMP) and 3–4 μM (C subunit). For all three agents the maximum increase in the Ca current density was similar (a factor of 3–4), suggesting that they converge on the same site of the Ca channel. Accordingly, the effects of cAMP and C subunit onI Ca were non-additive to those of ISP. From these data the relationship both between concentrations of ISP and cAMP and between those of cAMP and active C subunit in terms of their effects onI Ca could be estimated and were compared with those obtained in broken cell preparations. A competitive inhibitor of phosphorylation, 5′-adenylyl-imidodiphosphate (5 mM), greatly reduced the effects of ISP and C subunit onI Ca. Cell dialysis with 3 mM adenosine-5′-(γ-thio)-triphosphate, which produces a dephosphorylationresistant phosphorylation, markedly potentiated the effects of ISP and cAMP onI Ca. The results support the hypothesis that phosphorylation of a protein within, or close to, the Ca channel by cAMP-dependent protein kinase is the mechanism of β-adrenergic stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582573
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  • 9
    Electronic Resource
    Electronic Resource
    Hydroxidgruppen an Zeolithen. II. Zahl und Eigenschaften von Hydroxidgruppen an CeNaY- und HNaY-Zeolithen unterschiedlichen Austauschgrades (1974)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 404 (1974), S. 142-160 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Hydroxide Groups on Zeolites. II. Number and Properties of Hydroxide Groups on CeNaY and HNaY Zeolites of Different Exchange DegreeThe number of hydroxide groups on CeNaY and HNaY zeolites was examined by D2 exchange, and their properties in dependence of the cation exchange degrees were studied by IR spectroscopy. On CeNaY zeolites there exist six kinds and on HNaY zeolites at least seven kinds of hydroxide groups.On the CeNaY zeolites, the hydroxide groups are produced by dissociative chemisorption of water on Ce3+ ions. Their total number increases continuously with increasing exchange degree. Some of the hydroxide groups are acid BRÖNSTED centers whose number increases with increasing exchange degree and decreases with the temperature of preheating increasing to about 600°C.On the HNaY zeolites, the hydroxide groups are produced by thermal decomposition of the NH+4 ions, by dealumination and interaction of the Al3+ ions produced in this way in the place of cations with water. Above the threshold value of 35% the total number of the hydroxide groups increases very rapidly with increasing exchange degree. One part of the hydroxide groups decreasing with increasing exchange degree acts as acid BRÖNSTED centers. The number of these centers does not decrease until at preheating temperatures above 450°C.
    Notes: An CeNaY- und HNaY-Zeolithen wurden durch D2-Austausch die Zahl und infrarotspektroskopisch die Eigenschaften der Hydroxidgruppen in Abhängigkeit vom Kationenaustauschgrad untersucht. Es existieren an CeNaY-sechs Arten und an HNaY-Zeolithen mindestens sieben Arten von Hydroxidgruppen.An den CeNaY-Zeolithen entstehen die Hydroxidgruppen durch dissoziative Chemisorption von Wasser an Ce3+-Ionen. Ihre Gesamtzahl wächst kontinuierlich mit steigendem Austauschgrad. Einige der Hydroxidgruppen sind saure BRÖNSTED-Zentren, deren Zahl mit steigendem Austauschgrad wächst und mit steigender Vorerhitzungstemperatur bis etwa 600°C sinkt.An den HNaY-Zeolithen entstehen die Hydroxidgruppen durch thermische Zersetzung der eingetauschten NH+4-Ionen und mit wachsendem Austauschgrad zunehmend durch das Herauslösen von Gitteraluminium und Wechselwirkung der so entstehenden Al3+-Ionen auf Kationenplätzen mit Wasser. Die Gesamtzahl der Hydroxidgruppen wächst oberhalb des Schwellenwertes von 35% sehr stark mit steigendem Austauschgrad an. Ein mit steigendem Austauschgrad abnehmender Anteil der Hydroxidgruppen wirkt als saure BRÖNSTED-Zentren, deren Zahl erst bei Vorerhitzungstemperaturen oberhalb von 450°C abnimmt.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19744040206
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  • 10
    Electronic Resource
    Electronic Resource
    Untersuchungen an oxidischen Katalysatoren. XXIX. Spektroskopische und katalytische Untersuchungen an Ni2+-, Co2+-, Cr3+- und Cu2+-ausgetauschten MordenitenProfessor Günther Rienäcker gewidmet (1979)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 452 (1979), S. 6-16 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Studies on Oxide Catalysts. XXIX. Spectroscopic and Catalytic Investigations on Ni2+-, Co2+-, Cr3+-, and Cu2+-exchanged MordenitesNiNaM, CoNaM, CrNaM und CuNaM (M = Mordenite) have been characterized by UV-VIS, EPR and i.r. spectroscopy and the results were compared with the catalytic activity and the activity-time-dependence in the cracking of n-octane and with the shape selectivity in the cracking of a n-octane and isooctane mixture. Water molecules acting as ligands of the exchanged cations are able to dissociate yielding Brönsted acidity. Brönsted sites may be regarded as catalytic active centers in the cracking reaction. Unreduced transition metal cations facilitate the “coking” of the mordenite.The unreduced chromium and cobalt cations for which a position within the main channel is expected, affect the diffusion of the branched paraffin molecule thus increasing shape selectivity.
    Notes: NiNaM, CoNaM, CrNaM und CuNaM (M = Mordenit) wurden durch UV-VIS-Spektroskopie, EPR- und IR-Untersuchungen charakterisiert und die erhaltenen Ergebnisse mit der katalytischen Aktivität und dem Aktivitäts-Zeit-Verhalten dieser Proben bei der Spaltung von n-Octan und der Formselektivität in der Spaltung eines Gemisches von n/iso-Octan verglichen. Wassermolekeln als Liganden der eingetauschten Kationen können dissoziieren und so einen Beitrag zur Brönsted-Acidität liefern. Die Brönsted-Zentren können als katalytisch aktive Zentren in der Spaltreaktion angesehen werden. Nichtreduzierte Übergangsmetallkationen vergrößern die Neigung des Mordenits zum „Verkoken“ wesentlich. Die nichtreduzierten Co2+- und Cr3+-Kationen, für die eine Position im Hauptkanal angenommen werden kann, wirken als zusätzliche Diffusionsbremse auf die verzweigte Paraffinmolekel und erhöhen die Formselektivität des Mordenits.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19794520103
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